Publications by authors named "Hong-Shan Yin"
Objective: MicroRNAs (miRNAs) have been shown to play an important role in myocardial ischemia/reperfusion (MI/R) injury. This study aimed to determine the role of miR-432 in MI/R injury.
Methods: We established a MI/R injury model by ligation/untying of the left anterior descending coronary artery, and used viral infection to regulate gene expression, such as that of miR-432 and , and used RT-qPCR to detect the expression of the gene at mRNA level.
Nesfatin-1 (encoded by NUCB2) is a cardiac peptide possessing protective activities against myocardial ischaemia/reperfusion (MI/R) injury. However, the regulation of NUCB2/nesfatin-1 and the molecular mechanisms underlying its roles in MI/R injury are not clear. Here, by investigating a mouse MI/R injury model developed with transient myocardial ischaemia followed by reperfusion, we found that the levels of NUCB2 transcript and nesfatin-1 amount in the heart were both decreased, suggesting a transcriptional repression of NUCB2/nesfatin-1 in response to MI/R injury.
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- Arctigenin (ATG) exhibits various beneficial properties, including anti-inflammatory and anti-carcinogenic effects, but its potential in preventing arrhythmias during myocardial ischemia/reperfusion had not been studied prior to this research.
- Rats were tested using different doses of ATG before being subjected to myocardial ischemia/reperfusion, with results showing that higher doses of ATG significantly reduced the occurrence and duration of dangerous heart rhythms like ventricular fibrillation and tachycardia.
- The findings indicated that ATG helps in preventing arrhythmias possibly through enhancing antioxidant enzyme activities and increasing the expression of protective proteins, confirming its protective role in cardiac injury.
Nicotine-induced ICAM-1 and VCAM-1 expression in mouse cardiac vascular endothelial cell via p38 MAPK signaling pathway.
Anal Quant Cytopathol Histpathol
October 2014
Objective: To explore the link between cigarette smoking and thromboembolic events and to investigate cigarette smoking as a major risk factor in the etiology of atherosclerosis.
Study Design: We determined the effect of nicotine on the expression of adhesion molecules, intercellular adhesion molecule (ICAM-1), and vascular cell adhesion molecule (VCAM-1) in mouse cardiac vascular endothelial cells and the involvement of important known intermediaries, namely p38 mitogen-activated protein kinase (MAPK) signaling pathway.
Results: Our results indicate that nicotine can enhance the expression of ICAM-1 and VCAM-1 on mouse cardiac vascular endothelial cell via p38 MAPK signaling pathway, resulting in increased expression of the cellular adhesion molecules ICAM-1 and VCAM-1.
Application of low dose of FK506 in pancreas transplantation model in Wistar-SD rats.
Immunopharmacol Immunotoxicol
August 2012
Objective: To probe into application of low dose of FK506(Tacrolimus) in pancreas transplantation.
Methods: Effects of low-dose FK506 (Tacrolimus) in pancreas transplantation with examination of ELISA Electron microscopy and TUNEL by method of random control were studied.
Results: Blood glucose concentration in control group is higher than that in treated group A (FK506) and treated group B (CsA) 7 days after transplantation (p < 0.
Mechanisms of diabetes mellitus induced with FK506 in SD rats models.
Immunopharmacol Immunotoxicol
June 2010
Background: Tacrolimus causes post-transplant diabetes mellitus, however the pathogenetic mechanisms remain controversial. In this study we probed into the mechanisms of tacrolimus-induced diabetes mellitus in rats.
Methods: Glucose levels were determined on whole blood samples using a glucose oxidase method.