Publications by authors named "Hong-Rong Cheng"
Article Synopsis
- * The study analyzed genetic data from 29 FTD patients, identifying 2 known pathogenic variants (MAPT and TBK1) and 4 novel variants (including MAPT and GRN), with various impacts on tau protein functionality.
- * Findings suggested that specific variants (p.R406Q, p.D430H, c.350-2A>G) are pathogenic and contributed to an expanded understanding of FTD genetics within East Asian populations.
Background: Studies concerning the impact of the AT(N) framework on diagnostic capability in the dementia population are lacking. We aimed to explore the diagnostic application of CSF AT(N) framework in clinical routines of Alzheimer's disease (AD) as well as differential diagnosis of other cognitive diseases in the Chinese Han population.
Patients And Methods: A total of 137 patients with cognitive disorders received CSF tests of Aβ, t-tau and p-tau.
Article Synopsis
- Researchers measured β-amyloid 42 and tau proteins in cerebrospinal fluid (CSF) to differentiate Alzheimer's disease (AD) from other neurodegenerative diseases in a cohort of Chinese patients.
- The study included 240 patients across various conditions, finding high discriminative ability of these biomarkers for identifying AD except for elevated tau in frontotemporal dementia (FTD).
- This study is significant as it is the first of its kind in the Han Chinese population, confirming the usefulness of these biomarkers in distinguishing AD from other diseases.
Huntington's disease (HD) is an autosomal dominant inherited neurodegenerative disorder caused by CAG triplet repeats expansion in exon 1 of the Huntingtin gene (). In China, HD is considered to have a low prevalence. The goal of this study was to describe the clinical characteristic and genetic profiles of HD in a Chinese cohort.
View Article and Find Full Text PDFHuntington's disease (HD) is an autosomal dominant degenerative disease that mainly encompasses movement, cognition, and behavioral symptoms. The apolipoprotein E (APOE) gene is thought to be associated with many neurodegenerative diseases. Here, we enrolled a cohort of 223 unrelated Han Chinese patients with HD and 1241 unrelated healthy controls in Southeastern China and analyzed the correlation between APOE genotypes and HD phenotypes.
View Article and Find Full Text PDFFamilial Alzheimer's disease (FAD) is characterized by a positive family history of dementia and typically occurs at an early age with an autosomal dominant pattern of inheritance. Amyloid precursor protein (APP), presenilin1 (PSEN1), and presenilin2 (PSEN2) are the major causative genes of FAD. The spectrum of mutations in patients with FAD has been investigated extensively in the Caucasian population but rarely in the Chinese population.
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