Publications by authors named "Hong-Ran Yin"
Bioorg Med Chem
July 2015
Article Synopsis
- A new class of compounds based on rhodanine and 4-anilinoquinazoline was designed by combining quinazoline with various rhodanine groups.
- These compounds were tested for their ability to inhibit cell growth (antiproliferative activity) and showed promising results, particularly in blocking the activity of EGFR-TK.
- Specifically, compound 8d exhibited strong inhibitory effects with low IC50 values against liver cancer (Hep G2) and lung cancer (A549) cell lines, and molecular docking suggested that its structure fits well in the EGFR TK active site, explaining its effectiveness.
