Cardiotoxicity monitoring of pyrotinib in combination with nab-paclitaxel, doxorubicin, and cyclophosphamide in HER2-positive breast cancer: a single-armed clinical trial.

Background: Human epidermal growth factor receptor 2 (HER2) inhibitors play a vital role in the treatment of HER2-positive breast cancer. Numerous studies have shown that traditional HER2 inhibitors and chemotherapeutics such as albumin-paclitaxel, liposomal doxorubicin, and cyclophosphamide (TAC regimen) have different degrees of cardiotoxicity. Pyrotinib is a novel small-molecule HER2 inhibitor and has no cardiotoxicity.

[High-Sensitive Carbon Dioxide Detection Using Quartz-Enhanced Photoacoustic Spectroscopy with a 2.0 μm Distributed Feedback Laser].

A carbon dioxide (CO2) sensor is developed using quartz enhanced photoacoustic spectroscopy (QEPAS) with a 2.0 μm distributed feedback diode laser. The detection is based on a 2f wavelength-modulation spectroscopy approach by dithering and scanning the laser current.

[Experimental research on optimization of QEPAS based spectrophone].

The present paper studied the impact of geometry dimensions, located angle and detection position of a quartz tuning fork (QTF) on the sensitivity of QEPAS system. Ten kinds of QTFs were employed to compare the sensitivity with each other, and the results show that the QTF with a wedge-shape top obtains a higher quality factor and turns to be 50% more sensitive than the ones with a regular cuboid top when detecting the water concentration at 7 306 cm-1. By studying the located angle of a QTF, it was found that it nearly makes no difference, but more noise is introduced when there is an angle phi between the laser beam and QTF.