Publications by authors named "Hong-Pei Ji"
Article Synopsis
- Primary open-angle glaucoma (POAG) is a widespread eye disease with no effective treatment, highlighting the need for better diagnostic markers for patient care.
- Researchers analyzed gene expression data to identify key co-expressed genes, with five oxidative stress-related genes (HBB, MAOA, ACOX2, ALDH7A1, and TYMP) showing high potential for POAG diagnostics based on advanced machine learning methods.
- Immune cell infiltration was notably altered in POAG patients, with increased levels of certain immune cells and a drug sensitivity analysis revealing potential treatment options such as Acetalax_1804 and Ibrutinib_1799.
Article Synopsis
- Retinal degenerative diseases lead to irreversible loss of photoreceptors, with cell replacement therapy being a promising treatment approach.
- Müller glia in the retina can serve as source cells due to their ability to revert to a progenitor-like state, showing characteristics like stem cell markers and self-renewal potential.
- Research identified that the microRNA miR-28 negatively regulates CRX, a key transcription factor for photoreceptors; inhibiting miR-28 promotes differentiation of Müller glia-derived progenitors into neurons expressing photoreceptor-specific proteins, suggesting a potential pathway for treatment.
Objective: Müller cells can be acquired from in vitro culture or a neurosphere culture system. Both culture methods yield cells with progenitor-cell characteristics that can differentiate into mature nervous cells. We compared the progenitor-cell traits of Müller cells acquired from each method.
View Article and Find Full Text PDFRetinitis pigmentosa (RP) is a group of inherited neurodegenerative diseases characterized by the loss of photoreceptor cells through apoptosis. N-methyl-N-nitrosourea (MNU) is an alkylating toxicant that induces photoreceptor cell death resembling hereditary RP. This study aimed to investigate the role of nuclear factor κB (NF-κB) in MNU-induced photoreceptor degeneration.
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