[Association between toll-like receptors 2 and 5 polymorphisms and neonatal sepsis].

Objective: To study the association between single nucleotide polymorphisms(SNP) in toll-like receptors (TLR) 2 and 5 genes and the susceptibility to neonatal sepsis.

Methods: One hundred and fourteen newborn infants who were diagnosed with clinical sepsis (case group) between May 2011 and January 2014 and 172 newborn infants without infection(control group) were enrolled in this study. The polymorphisms of TLR2 (rs5743708 and rs3804099) and TLR5 (rs5744105) were analyzed using a SNaPshot multiplex reaction to compare the genotypic and allelic frequencies between two groups.

[NF-kappaB-mediated protective effect of erythropoitin on neuron against glutamate-induced damage].

Aim: To investigate protective effect and possible mechanisms of erythropoitin (EPO) on cortical neuron against damage induced by glutamate(Glu).

Methods: Cortical neurons were removed from 1-day-old newborn rat and then cultured in vitro. The model of damage induced by Glu was established.

[Study on the expression of C-erbB-2 gene in coal miners with pneumoconiosis complicated by pulmonary cancer].

Objective: To study the difference in the expressions of C-erbB-2 gene between the coal miners with pneumoconiosis complicated by pulmonary cancer and the controls with single pulmonary cancer, and its relation to clinical pathology.

Method: Measuring the expressions of C-erbB-2 in 32 cases of pneumoconiosis complicated by pulmonary cancer and those in 30 cases of pulmonary cancer by means of immunohistochemistry.

Results: The positive expression rate in 32 cases of pneumoconiosis complicated by pulmonary cancer was 53.