Chronic Ketamine Exposure Causes White Matter Microstructural Abnormalities in Adolescent Cynomolgus Monkeys.

Acute and repeated exposures to ketamine mimic aspects of positive, negative, and cognitive symptoms of schizophrenia in humans. Recent studies by our group and others have shown that chronicity of ketamine use may be a key element for establishing a more valid model of cognitive symptoms of schizophrenia. However, current understanding on the long-term consequences of ketamine exposure on brain circuits has remained incomplete, particularly with regard to microstructural changes of white matter tracts that underpin the neuropathology of schizophrenia.

HSP70 expression in the hippocampal CA3 subfield in different chronic stress models.

This study examined the heat shock protein 70 (HSP70) expression in hippocampal CA3 subfield of rats in different chronic stress models. The chronic restraint stress (CRS) and the chronic mild stress (CMS) models were used in this study. Observation of exploratory behavior in an open field test indicated stress level.