Publications by authors named "Hong-Li Chi"
Background: In the hypothalamic paraventricular nucleus (PVN) of spontaneously hypertensive rats (SHRs), the expression of the testis-specific protein, Y-encoded-like 2 (TSPYL2) and the phosphorylation level of Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) are higher comparing with the normotensive Wistar Kyoto rats (WKY). But how they are involved in hypertension remains unclear. TSPYL2 may interact with JAK2/STAT3 in PVN to sustain high blood pressure during hypertension.
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- N-Methyl-d-aspartate receptors (NMDAR) in the hypothalamic paraventricular nucleus (PVN) are important for controlling sympathetic nerve activity, but their long-term effects in hypertension are not well understood.
- The study used PEAQX, a specific NMDAR subunit 2A antagonist, on hypertensive rats over three weeks, which resulted in lower blood pressure and improved the balance of neurotransmitters.
- It was found that chronic NMDAR blockade reduced levels of certain proteins and inflammatory markers, and affected specific signaling pathways, particularly decreasing the activity of the MEK/ERK/CREB pathway linked to hypertension.
Oxidative stress in the hypothalamic paraventricular nucleus (PVN) contributes greatly to the development of hypertension. The recombinant nuclear respiratory factor 1 (Nrf1) regulates the transcription of several genes related to mitochondrial respiratory chain function or antioxidant expression, and thus may be involved in the pathogenesis of hypertension. Here we show that in the two-kidney, one-clip (2K1C) hypertensive rats the transcription level of Nrf1 was elevated comparing to the normotensive controls.
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- Gut dysbiosis and gut-brain-axis dysregulation are linked to hypertension, and Vitamin C (VC) has potential anti-hypertensive effects in hypertensive rats.
- A study showed that daily VC intake (200 or 1000 mg/kg) improved blood pressure, gut microbiota diversity, and gut health in spontaneously hypertensive rats after 4 weeks.
- The findings suggest that VC’s anti-hypertensive effects may stem from its ability to reshape gut microbiota and reduce inflammation and oxidative stress in the brain region responsible for blood pressure regulation.
Aims: Exercise and food supplement of vitamin C (VC) are beneficial to human health, especially for those who suffer from hypertension. Here we tend to explore if gut microflora is involved in the anti-hypertensive effects of exercise and VC-supplement therapies.
Materials And Methods: With the spontaneously hypertensive rat (SHR) model, the small intestine pathology and the fecal microbiota was analyzed along with the pro- and anti-inflammatory cytokines (PICs and AICs) and reactive oxygen species (ROS) in the hypothalamus paraventricular nucleus (PVN) and intestine.
Background: This prospective observatory study was designed to investigate whether plasma visfatin might serve as a marker of prognosis in patients with severe carbon monoxide (CO) poisoning.
Methods: A total of 52 consecutive patients with severe CO poisoning and 52 gender- and age- matched healthy subjects were enrolled in the study, and their plasma visfatin levels were determined using an enzyme-linked immunosorbent assay. The clinical outcomes, including in-hospital mortality, 6-month mortality, and poor outcome (Glasgow Outcome Scale score of 1 - 3), were recorded.