The study aimed to evaluate the effectiveness and safety of noninvasive high-frequency oscillatory ventilation (NHFOV) compared to nasal intermittent positive pressure ventilation (NIPPV) in providing respiratory support for preterm infants after extubation.
A meta-analysis of 9 randomized controlled trials showed that NHFOV significantly reduced the reintubation rate within 72 hours and the partial pressure of carbon dioxide (PCO) levels shortly after switching to noninvasive ventilation.
NHFOV was found to be safer than NIPPV, as it did not increase the risk of complications like bronchopulmonary dysplasia or intraventricular hemorrhage, suggesting it is a viable option for post-extubation respiratory