Tyrosine metabolic reprogramming coordinated with the tricarboxylic acid cycle to drive glioma immune evasion by regulating PD-L1 expression.

Due to the existence of the blood-brain barrier in glioma, traditional drug therapy has a poor therapeutic outcome. Emerging immunotherapy has been shown to have satisfactory therapeutic effects in solid tumors, and it is clinically instructive to explore the possibility of immunotherapy in glioma. We performed a retrospective analysis of RNA-seq data and clinical information in 1027 glioma patients, utilizing machine learning to explore the relationship between tyrosine metabolizing enzymes and clinical characteristics.

Facile Photoresponsive Actuators Based on Ferrocene-Doped Poly(butyl methacrylate).

This paper presents facile photoresponsive actuators comprising ferrocene as a guest chromophore and poly(butyl methacrylate) (PBMA) as a host matrix. The ferrocene-doped PBMA film exhibits mechanical expansion and contraction when a 445 nm laser is turned on and off, respectively. The photoresponsive film is attached by a commercially available acetylcellulose adhesive tape, which exhibits a bending motion that is controlled by turning the laser on and off.