Publications by authors named "Hong-Juan Ding"
Preeclampsia is characterized by insufficient invasion of extravillous trophoblasts and is a consequence of failed adaption of extravillous trophoblasts to changes in the intrauterine environment developing embryo. Specific miRNAs are implicated in the development of preeclampsia (PE). miR-455-5p is present at low levels in PE but its role is not known.
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- - Gestational diabetes mellitus (GDM) is linked to a significantly higher risk (7.1 times) of developing pancreatic cancer in women, potentially years before diagnosis, with 36% of pancreatic cancer patients experiencing blood clotting issues (thromboembolic events).
- - A case report detailed a 29-year-old woman with GDM who showed severe complications, including signs of disseminated intravascular coagulation and pulmonary hypertension, and required aggressive medical intervention after giving birth.
- - Post-delivery, lab tests indicated elevated tumor markers and imaging revealed pancreatic cancer, demonstrating the severe health risks associated with GDM and its potential progression to malignancy.
Introduction: Pre-eclampsia (PE) can endanger the survival of the mother and fetus. Currently, the pathogenesis of PE is not completely understood and no fundamental therapeutics are available. The present study was performed to determine the function of miR-128a in HTR-8/SVneo trophoblast cells and to ascertain its underlying role in the pathogenesis of PE.
View Article and Find Full Text PDFAims: To investigate the contribution of dysfunction of maternal hemodynamics to renal impairment in preeclampsia (PE).
Methods: Urinary protein excretion, serum creatinine, blood urea nitrogen, uric acid, and glomerular filtration rate were assessed in 571 pregnant women with PE in addition to and noninvasive hemodynamic monitoring. Patients were classified into two groups: PE with renal impairment (glomerular filtration rate <90 ml/min/1.
The development of preeclampsia (PE) seriously affects the health of the mother and the child, but the precise pathogenesis of PE remains elusive. The placenta is considered to play a key role and DNA methylation may be associated with altered placental development and function. The aim of this study was to perform a genome-wide analysis of the DNA methylation profile in placentas from pregnancies with severe preeclampsia.
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