A predictive model for frequent exacerbator phenotype of acute exacerbations of chronic obstructive pulmonary disease.

Background: The frequent exacerbator phenotype of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) is characterized by experiencing at least two exacerbations per year, leading to a significant economic burden on healthcare systems worldwide. Although several biomarkers have been shown to be effective in assessing AECOPD severity in recent years, there is a lack of studies on markers to predict the frequent exacerbator phenotype of AECOPD. The current study aimed to develop a new predictive model for the frequent exacerbator phenotype of AECOPD based on rapid, inexpensive, and easily obtained routine markers.

Cationic Covalent Organic Nanosheets for Rapid and Selective Capture of Perrhenate: An Analogue of Radioactive Pertechnetate from Aqueous Solution.

Capture of radioactive TcO from nuclear wastes is extremely desirable for waste disposal and environmental restoration. Here, we report the synthesis of hydrolytically stable cationic covalent organic nanosheets (iCON) for efficient uptake of ReO, a nonradioactive surrogate of TcO. The iCON combines cationic guanidine-based knots with hydroxyl anchored neutral edge units and chloride ions loosely bonded in the pores, rendering extremely fast exchange kinetics toward ReO with high uptake capacity of 437 mg g and prominent distribution coefficient of 5.