Publications by authors named "Hong-Jie Kang"
Article Synopsis
- A study examined the effects of Lycii Fructus extracts from various origins on retinal degenerative diseases in mice, utilizing a model induced by NaIO_3 injections.
- Researchers assessed visual function, retinal apoptosis, and retinal thickness using methods like dark-light transition tests and optical coherence tomography, alongside measuring levels of oxidative stress, inflammation, and angiogenesis.
- The analysis revealed that extracts from Ningxia showed superior therapeutic benefits compared to those from other regions, supporting the idea of selecting optimal sources of Lycii Fructus for treating retinal issues.
Article Synopsis
- This study analyzed the chemical properties and fruit traits of 8 Lycium species in China, focusing on the content of various compounds such as monosaccharides, polysaccharides, and carotenoids.
- *The findings revealed specific species high in certain compounds, with L. barbarum noted for its polysaccharide and carotenoid content, while L. yunnanense and L. chinense were rich in soluble proteins.
- *Multivariate analysis identified key compounds differentiating species and revealed significant correlations between fruit traits like weight and seed-to-fruit ratio with the content of various chemical compounds.
Article Synopsis
- - The study investigates the pharmacokinetic differences of twelve key constituents in the herbal remedy Qihe Fenqing Yin, focusing on their behavior in normal versus diabetic rats, which were induced using a high-fat diet and streptozocin injections.
- - A specialized UHPLC-QTRAP-MS/MS method was developed to analyze the constituents in rat plasma after administering the herbal remedy, demonstrating the method's reliability in terms of linearity, accuracy, and stability.
- - Results indicate that most constituents show prolonged half-lives in diabetic rats compared to normal rats, and significant differences in the area under the curve (AUC) and mean residence time (MRT) were observed, highlighting altered pharmacokinetics in disease states. *
Article Synopsis
- The study investigates the protective effects of four goji berry cultivars against retinal degeneration in a mouse model induced by NaIO, focusing on identifying the most effective cultivar.
- Using various assays, researchers assessed visual function and retinal cell health while analyzing the compound profiles of the goji extracts.
- Results showed that Ningqi No.1 cultivar was most effective at reducing oxidative stress and inflammation, making it the leading candidate for further investigation in retinal health treatments.
Article Synopsis
- - The study focused on identifying the metabolites of Yiqi Baoyuan Prescription (YQBYP) in rats using advanced techniques like UPLC-TOF-MS.
- - Researchers analyzed samples from rat plasma, bile, urine, and feces, identifying 9 prototype components and 36 metabolites.
- - The findings highlighted the main metabolic pathways of YQBYP, including various phase Ⅰ and phase Ⅱ reactions, contributing to the understanding of its therapeutic effects and potential product development.