Publications by authors named "Hong-Jiao Li"

With the excellent ability to transform near-infrared light to localized visible or UV light, thereby achieving deep tissue penetration, lanthanide ion-doped upconversion nanoparticles (UCNP) have emerged as one of the most striking nanoscale materials for more effective and safer cancer treatment. Up to now, UCNPs combined with photosensitive components have been widely used in the delivery of chemotherapy drugs, photodynamic therapy and photothermal therapy. Applications in these directions are reviewed in this article.

View Article and Find Full Text PDF

Background: Derivation of osteoblast-like cells from human pluripotent stem cells (hPSCs) is a popular topic in bone tissue engineering. Although many improvements have been achieved, the low induction efficiency because of spontaneous differentiation hampers their applications. To solve this problem, a detailed understanding of the osteogenic differentiation process of hPSCs is urgently needed.

View Article and Find Full Text PDF

Members of the ten-eleven translocation (TET) protein family of which three mammalian TET proteins have been discovered so far, catalyze the sequential oxidation of 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine which serve an important role in embryonic development and tumor progression. O-GlcNAcylation (O-linked β-N-acetylglucosaminylation) is a reversible post-translational modification known to serve important roles in tumorigenesis and metastasis especially in hematopoietic malignancies such as myelodysplastic syndromes, chronic myelomonocytic leukemia and acute myeloid leukemia. O-GlcNAcylation activity requires only two enzymes: O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA).

View Article and Find Full Text PDF

Objective: To investigate the effect of bone marrow stromal cell glycosyltransferase B4GALT1 expression on hematopoietic cell proliferation and its upstream regulation mechanism.

Methods: B4GALT1 was overexpressed in human bone marrow stromal cell line HS5, which was then co-cultured with acute myeloid leukemia cell line KG1a. And its effect on hematopoietic cell proliferation was detected by flow cytometry.

View Article and Find Full Text PDF
Article Synopsis
  • The text details a review of clinical research articles on subcutaneous needling therapy (FSN) from multiple databases up to January 2018, resulting in a total of 412 articles.
  • FSN has been used to treat 65 types of diseases across 11 body systems, with musculoskeletal pain disorders being the most common.
  • Experts suggest focusing future FSN clinical research on muscle-related disorders, emphasizing the need for more high-quality studies to support its therapeutic effectiveness.
View Article and Find Full Text PDF

Two hundred eighteen PM and 202 PM samples were collected at three sampling sites to study the pollution characteristics of carbonaceous aerosols in Yulin from July 2015 to March 2016. Organic carbon (OC) and elemental carbon (EC) in the PM and PM samples were analyzed by a Multiwavelength Thermal/Optical Carbon Analyzer, and the characteristics, including pollution levels, temporal and spatial distributions, and possible sources of OC and EC, were investigated. The results showed that the OC and EC mass concentrations in PM in Yulin were 10.

View Article and Find Full Text PDF

Distribution characteristics, chemical constituents, and sources of particulate matter were measured using a scanning mobility particle sizer and single particle aerosol mass spectrometer during pollution monitoring that occurred between December 5 and December 11, 2016, in Nanning. Results showed that particulate matter (PM) sized between 20 nm-10 μm were concentrated in the 23 to 395 nm range, with a peak of 100 nm. Three new particle types were generated during the course of this monitoring.

View Article and Find Full Text PDF

The formation of high quality homogeneous active component films is essential to the fabrication of many organic optoelectronic devices, especially those having a large area module. However, most small molecule (SM) semiconductors are unable to achieve such a goal solution processing because their large and rigid π-conjugated structures generally drive them to aggregate or crystallize into inhomogeneous domains in the process. In this work, a SM semiconductor (SM-DPP6T) based on a diketopyrrolopyrrole (DPP) center with three thiophene units on both sides encounters the same problem.

View Article and Find Full Text PDF

To study the chemical composition and pollution sources of the fine particulate matter during the four seasons in Nanning, single particle aerosol mass spectrometry was performed to characterize the fine particulate matter in Nanning during the four seasons. The correlation () between the fine particulate matter number concentration and the mass concentration of the fine particulate matter obtained using SPAMS was all above 0.75 in the observation period.

View Article and Find Full Text PDF

The effective quality control in clinical practices is an effective guarantee for the authenticity and scientificity of the findings. The post-marketing reevaluation for traditional Chinese medicines (TCM) focuses on the efficacy, adverse reaction, combined medication and effective dose of drugs in the market by expanded clinical trials, and requires a larger sample size and a wider range of patients. Therefore, this increases the difficulty of quality control in clinical practices.

View Article and Find Full Text PDF

Inhibins play important roles in normal gonadal function, including regulation of proliferation, differentiation, and steroidogenesis of Leydig and Sertoli cells via paracrine and autocrine processes. In adult males, circulating inhibin levels are correlated with fertility by regulating the number of Sertoli cells, total sperm count, and testicular volume. Given this important role, inhibin-α subunit (INHA) is a strong candidate gene in male fertility.

View Article and Find Full Text PDF

To search for novel anticancer agents, we designed and synthesized a series of new triazolyl berberine derivatives. The evaluation of all the synthesized compounds and their anticancer activities against a panel of four human cancer cell lines including MCF-7 (breast), MCF-7/ADR (breast), SW-1990 (pancreatic), SMMC-7721 (liver) and the non-cancer cell line HUVEC (human umbilical vein endothelial cell). The results showed that most of the compounds displayed better anticancer activities against MCF-7 and SMMC-7721 compared with berberine.

View Article and Find Full Text PDF

To search for novel anticancer agents, we designed and synthesized a series of new triazolyl berberine derivatives. The evaluation of all the synthesized compounds and their anticancer activities against a panel of four human cancer cell lines including MCF-7 (breast), MCF-7/ADR (breast), SW-1990 (pancreatic), SMMC-7721 (liver) and the noncancer cell line HUVEC (human umbilical vein endothelial cell). The results showed that most of the compounds displayed better anticancer activities against MCF-7 and SMMC-7721 compared with berberine.

View Article and Find Full Text PDF

A new class of organic photovoltaic materials, poly(rod-coil) polymers composed of alternatively definite conjugated and non-conjugated segments, have been proposed. The first five examples based on polyurethane chemistry showed photovoltaic performance surpassing the reference compound, but less dependent on their molecular weight.

View Article and Find Full Text PDF

To effectively guarantee quality of randomized controlld trial (RCT) of acupuncture and develop reasonable content and checklist of on-site quality control, influencing factors on quality of acupuncture RCT are analyzed and scientificity of quality control content and feasibility of on-site manipulation are put into overall consideration. Based on content and checklist of on-site quality control in National 11th Five-Year Plan Project Optimization of Comprehensive Treatment Plan for TCM in Prevention and Treatment of Serious Disease and Clinical Assessment on Generic Technology and Quality Control Research, it is proposed that on-site quality control of acupuncture RCT should be conducted with PICOST (patient, intervention, comparison, out come, site and time) as core, especially on quality control of interveners' skills and outcome assessment of blinding, and checklist of on-site quality control is developed to provide references for undertaking groups of the project.

View Article and Find Full Text PDF

Aim: To investigate the expression profile of microRNAs in inoperable advanced non-small cell lung cancer (NSCLC) patients receiving chemotherapy and the potential relevance of microRNAs to clinicopathological characteristics and prognosis.

Methods: Serum samples were taken from 260 inoperable advanced NSCLC patients and 260 healthy individuals. All the patients received cisplatin-based chemotherapy, including NP/NC regimens, GP/GC regimens, and TP/TC regimens.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessions53852bm57rtsffr6v16dstt8r9vtj1g): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once