Publications by authors named "Hong-Jia Zhu"
Relapsed or refractory T-cell acute lymphoblastic leukemia/lymphoma (r/r T-ALL/LBL) are frequently aggressive and associated with unfavorable prognoses. Pan-targeted Chimeric Antigen Receptor (CAR) T-cell therapy have shown promising results in clinical trials. In recent years, CD7 CAR T-cell and CD5 CAR T-cell demonstrate effectiveness in treating r/r T-ALL/LBL patients with bone marrow infiltration.
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- Severe cytokine release syndrome (sCRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) hinder the use of CAR T-cell therapy, prompting researchers to develop a new CAR (ssCART-19) that incorporates shRNA to target the IL-6 gene.
- In a study involving 87 patients with relapsed/refractory B-cell acute lymphoblastic leukemia, ssCART-19 demonstrated significantly lower rates of grade ≥3 CRS (14.89%) and ICANS (4.26%) compared to conventional CAR T-cells (cCART-19) which had rates of 37.5% and 15%, respectively.
- Overall response rates and survival metrics were comparable
Ferulic acid (FA), a naturally derived phenolic compound, has antioxidant and antidepressant-like effects. It is still a challenge to study its mechanism due to the complexity of the pathophysiology of depression. In this study, ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) was used to perform metabolomics studies based on biochemical changes in differentiated rat pheochromocytoma (PC12) cells treated with corticosterone-induced neurological damage after FA treatment.
View Article and Find Full Text PDFComparative analysis of the compatibility effects of Danggui-Sini Decoction on a blood stasis syndrome rat model using untargeted metabolomics.
J Chromatogr B Analyt Technol Biomed Life Sci
January 2019
Danggui-Sini Decoction (DSD) is one of the most widely used traditional Chinese medicine formulae (TCMF) for treating various diseases caused by cold coagulation and blood stasis due to its effect of nourishing blood to warm meridians in clinical use. However, studies of the mechanism of how it dispels blood stasis and its compatible regularity are challenging because of the complex pathophysiology of blood stasis syndrome (BSS) and the complexity of DSD, with multiple active ingredients acting on different targets. Observing variations of endogenous metabolites in rats with BSS after administering DSD may further our understanding of the mechanism of BSS and the compatible regularity of DSD.
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- Liver fibrosis, which can lead to serious liver diseases like cirrhosis and hepatocellular carcinoma, is often a result of various chronic liver conditions.
- The traditional Chinese medicine, Corydalis saxicola Bunting (CS), shows promise in protecting the liver, but more research is needed to uncover its mechanisms.
- Using a combination of H-NMR-based metabonomics and network pharmacology, this study identified specific metabolic changes and potential targets in liver fibrosis that CS affects, suggesting that compounds like chelerythrine and sanguinarine may be key to its anti-fibrosis effects.