Publications by authors named "Hong-Ji Dai"
Background: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a newly proposed definition of fatty liver disease (FLD) independent of excessive alcohol consumption (EAC) and hepatitis viral infection. Evidence on the mortality risk in different types of FLD [nonalcoholic FLD (NAFLD), alcoholic FLD (AFLD), and MAFLD] is sparse, hindering the identification of high-risk populations for preferential clinical surveillance.
Methods: A total of 11,000 participants in the Third National Health and Nutrition Examination Survey were enrolled.
Genome-wide association studies have identified 21 susceptibility loci associated with melanoma. These loci implicate genes affecting pigmentation, nevus count, telomere maintenance, and DNA repair in melanoma risk. Here, we report the results of a two-stage genome-wide association study of melanoma.
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- * A large genome-wide association study analyzed 17,187 BCC cases and 287,054 controls, confirming 17 genetic loci and discovering 14 new ones linked to BCC risk.
- * The newly identified genetic markers are connected to key biological processes such as telomere maintenance and immune regulation, enhancing our understanding of how BCC develops.
Article Synopsis
- Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer, impacting 7-11% of Caucasians in the U.S.
- A study involving 7,404 cSCC cases and 292,076 controls identified 11 significant genetic loci, including seven related to pigmentation.
- Four new susceptibility loci were discovered, linked to immune response, apoptotic pathways, and cellular growth, enhancing our understanding of cSCC's development.
Previous studies suggested that smoking and passive smoking could increase the risk of breast cancer, but the results were inconsistent, especially for Chinese females. Thus, we systematically searched cohort and case-control studies investigating the associations of active and passive smoking with breast cancer risk among Chinese females in four English databases (PubMed, Embase, ScienceDirect, and Wiley) and three Chinese databases (CNKI, WanFang, and VIP). Fifty-one articles (3 cohort studies and 48 case-control studies) covering 17 provinces of China were finally included in this systematic review.
View Article and Find Full Text PDFBackground: Evidence for associations between dietary factors and breast cancer risk is inconclusive among Chinese females. To evaluate this question, we conducted a systematic review of relevant case-control and cohort studies.
Methods: Studies were systematically searched among 5 English databases (PudMed, ScienceDirect, Wiley, Clinicaltrials.
Objective: To evaluate associations between tea consumption, alcohol drinking and physical activity and breast cancer risk among Chinese females.
Methods: Three English databases (PubMed, ScienceDirect and Wiley) and three Chinese databases (CNKI, WanFang and VIP) were independently searched by 2 reviewers up to December 2012, complemented by manual searches. The quality of included studies was assessed with the Newcastle-Ottawa Scale items.
[Epidemiological trend of gastric cancer in Tianjin, 1981-2002].
Zhonghua Yu Fang Yi Xue Za Zhi
April 2008
Article Synopsis
- The study aims to assess the trends in gastric cancer incidence and mortality in Tianjin to inform prevention and control strategies.
- Analysis of data from 1981 to 2002 reveals a decreasing trend in both incidence and mortality rates for males and females over 45, while younger males show an increasing trend and younger females remain stable.
- Despite the overall decline, gastric cancer continues to be a significant public health concern in Tianjin due to the aging population and various risk factors.