Publications by authors named "Hong-Guang Hu"
Objective: We assessed the feasibility of spectral CT imaging for diagnosing lung adenocarcinomas manifesting as ground-glass nodules (GGNs) with varying Ki-67 expression.
Methods: Spectral CT parameters in 116 patients with lung adenocarcinomas manifesting as GGNs were analyzed. Cases were grouped into pre-invasive/minimally invasive adenocarcinoma (pre/MIA) and invasive adenocarcinoma (IA) groups.
Background: Few studies about lung ground-glass nodules (GGNs) have been done using non-enhancement spectral computed tomography (CT) imaging.
Purpose: To examine the association between spectral CT parameters, Ki-67 expression, and invasiveness in lung adenocarcinoma manifesting as GGNs.
Material And Methods: Spectral CT parameters were analyzed in 106 patients with lung GGNs.
Article Synopsis
- - B-cell lymphoma 6 (BCL6) is a key protein involved in the development of B-lymphocytes and is linked to breast cancer progression, making it a potential target for research.
- - In a study involving 228 breast cancer patients, BCL6, along with zinc finger E-box-binding homeobox (ZEB)1 and ZEB2, showed significantly higher expression levels in cancerous tissues compared to benign cases, correlating with more aggressive tumor characteristics.
- - The findings indicate that high levels of BCL6, ZEB1, and ZEB2 are associated with poorer overall and relapse-free survival rates in breast cancer patients, suggesting they may serve as important biomarkers for cancer invasion and prognosis
Altered expression of Twist, matrix metalloproteinase (MMP)-2 and MMP-9 proteins has been identified in various types of human cancers. However, the correlation between Twist and these gelatinases in breast cancer remains unclear. In this study, immunohistochemical analysis of Twist, MMP-2 and MMP-9 expression was performed on tissue microarrays from 200 breast cancer cases.
View Article and Find Full Text PDFPurpose: The purpose of this study was to explore the correlation between the respiration-induced target motion and volume variation with the dosimetric variance on breast and organ at risk (OAR) during free breathing.
Methods And Materials: After breast-conserving surgery, seventeen patients underwent respiration-synchronized 4DCT simulation scans during free breathing. Treatment planning was constructed using the end inspiration scan, then copied and applied to the other phases and the dose distribution was calculated separately to evaluate the dose-volume histograms (DVH) parameters for the planning target volume (PTV), ipsilateral lung and heart.
This study was performed to explore and compare the dosimetric variance caused by respiratory movement in the breast during forward-planned IMRT after breast-conserving surgery. A total of 17 enrolled patients underwent the 3DCT simulation scans followed by 4DCT simulation scans during free breathing. The treatment planning constructed using the 3DCT images was copied and applied to the end expiration (EE) and end inspiration (EI) scans and the dose distributions were calculated separately.
View Article and Find Full Text PDFObjective: To explore the dosimetric variance in forward intensity modulated radiotherapy (IMRT) based on 4D CT and 3D CT after breast conserving surgery.
Methods: Seventeen patients after breast conserving surgery underwent 3D CT simulation scans followed by respiration-synchronized 4D CT simulation scans at free breathing state. The treatment plan constructed using the end inspiration (EI) scan was then copied and applied to the end expiration (EE), and 3D scans and dose distribution were calculated separately.