Photo-Controlled Nano-Supramolecular Size and Reversible Luminescent Behaviors Based on Cucurbit[7]uril Cascaded Assembly.

Supramolecular luminescent material with switchable behavior and photo-induced aggregation with emission enhancement is a current research hot spot. Herein, a size-tunable nano-supramolecular assembly with reversible photoluminescent behavior was constructed by noncovalent polymerization of diarylethene-bridged bis(coumarin) derivative (DAE-CO), cucurbit[7]uril (CB[7]), and β-cyclodextrin-grafted hyaluronic acid (HACD). Benefiting from the macrocyclic confinement effect, the guest molecule DAE-CO was included into the cavity of CB[7] to give enhanced fluorescence emission of the resulting DAE-CO⊂CB[7] with longer lifetime at 432 nm to 1.

A Meta-Analysis on the Impact of Prenatal and Early Childhood Antimicrobial Use on Autism Spectrum Disorders.

Objective: To investigate the impact of prenatal and early childhood antimicrobial use on autism spectrum disorders (ASD).

Data Sources: We searched PubMed and Embase databases for relevant studies from inception to August 2022.

Study Selection And Data Extraction: Peer-reviewed, observational studies were all acceptable.

Electroacupuncture at Zusanli ameliorates the autistic-like behaviors of rats through activating the Nrf2-mediated antioxidant responses.

Objective: Emerging evidence suggests that acupuncture plays a neuroprotective role in autism. This study aimed to explore the effect of electroacupuncture at Zusanli (ST36) on autistic-like behaviors and the underlying mechanism.

Method: Pregnant rats were administered with valproic acid (VPA) on gestational day 12.

Novel Porous Rhodium Metal-Organic Aerogel for Efficient Removal of Organic Dyes and Catalysis of Si-H Insertion Reactions.

Metal-organic gels (MOGs) are attracting increasing attention for removal of organic dyes from aqueous solution and for catalysis of Si-H insertion reactions. Herein, we report that a reaction of porphyrin derivative with Rh(OAc) generates stable metal-organic gels and subsequent subcritical carbon dioxide drying affords metal-organic aerogels. Owing to their micro- and mesoporosity, the aerogels adsorbed dyes.

Reversible Emitting Anti-Counterfeiting Ink Prepared by Anthraquinone-Modified -Cyclodextrin Supramolecular Polymer.

Intelligent fluorescent materials have been paid more and more attention due to their wide application in information encryption and anti-counterfeiting materials. Herein, a supramolecular polymer is constructed through the host-guest interaction of anthraquinone-modified -cyclodextrin (AQ--CD) in aqueous solution. Thanks to the hydrophobic microenvironment of the cyclodextrin cavity and the shielding effect on oxygen molecules, the anthraquinone group, as the guest molecule, can rapidly produce 9,10-anthracenediol (QH) with strong fluorescence by photoreduction.

Polysaccharide-Based Nanoparticles for Two-Step Responsive Release of Antitumor Drug.

A novel two-step in situ method for targeted antitumor drug release by supramolecular assembly (Fc-CPT@HACD) was constructed using camptothecin prodrug (Fc-CPT) and β-cyclodextrin (β-CD)-modified hyaluronic acid (HACD). Benefiting from the overexpressed HO and glutathione (GSH) in tumor cells, Fc-CPT@HACD can be disassembled by oxidation of ferrocene (Fc) to Fc, leading to an efficient release of the anticancer drug camptothecin (CPT) to induce tumor cell apoptosis without affecting normal cells. The in vivo experiment results also demonstrated that Fc-CPT@HACD possessed higher anticancer efficiency than free CPT, accompanied by negligible side effects.

Photo-controlled chirality transfer and FRET effects based on pseudo[3]rotaxane.

The use of light to regulate the chirality of supramolecular assemblies in a non-invasive manner remains a challenge. Herein, we report a novel photochromic pseudo[3]rotaxane based on a (R/S)-2,2'-binaphthyl secondary ammonium salt guest (2) and anthracene-bridged bis(dibenzo-24-crown-8) (1), which features a chirality transfer and fluorescence resonance energy transfer (FRET) from 2 to 1. Benefiting from the photo-oxidation of anthracene, the induced circular dichroism (ICD) signals of (R/S)-2@1 can be switched off/on by irradiation with 365 nm UV light and heating.

Multistimuli-Responsive and Photocontrolled Supramolecular Luminescent Gels Constructed by Anthracene-Bridged Bis(dibenzo-24-crown-8) with Secondary Ammonium Salt Polymer.

A novel multistimuli-responsive and photcontrolled supramolecular luminescent gel is fabricated from anthracene-bridged bis(dibenzo-24-crown-8) (1) and secondary ammonium salt-functionalized graft polymer (3). X-ray crystallographic analysis reveals that the dibenzo-24-crown-8 (DB24C8) ring is located at the opposite site of 1, which will greatly hinder the mutual intermolecular π-π stacking between anthracene groups. By taking advantage of the controllable binding of 1 with 3, the unique gel-sol transition could occur under different temperatures, pH, and competitive guest bindings.

A tumor-targeting Ru/polysaccharide/protein supramolecular assembly with high photodynamic therapy ability.

Supramolecular assembly with tumor-targeting properties or photodynamic therapy (PDT) ability has recently become a focus of interest in biomaterial field because of its high therapeutic efficacy against tumor cells. Herein, we reported a new type of targeted supramolecular nanoparticles for photodynamic therapy of tumor cells constructed using adamantane-functionalized transferrin protein (Ad-TRF) and a β-cyclodextrin-functionalized ruthenium complex (Ru-HOP-CD), wherein Ad-TRFs acted as the targeted sites for tumor cells, the coordinated Ru(ii) centers acted as the PDT active sites, and the biocompatible polysaccharide β-cyclodextrins acted as the non-covalent linkers. Significantly, the resultant Ru/polysaccharide/protein exhibited not only specific targeting properties towards tumor cells but also high PDT ability under the irradiation of visible light.

Impact of CYP2D6 Polymorphisms on Postoperative Fentanyl Analgesia in Gastric Cancer Patients.

Background: This study investigated the influence of human cytochrome P450 2D6 (CYP2D6) gene polymorphism in gastric cancer (GC) patients to understand the pharmacogenomic basis for patient response to postoperative fentanyl analgesia.

Methods: The prospective study design contained 212 patients recovering from radical gastrectomy. Peripheral blood samples were collected after general anesthesia, and CYP2D6 genotypes were analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.