Association between gene of gastrointestinal tumors, the expression of P-glycoprotein and resistance to chemotherapeutic drugs.

The aim of the present study was to examine and discuss the association between multidrug resistance 1 gene () of gastrointestinal tumors, the expression of P-glycoprotein and resistance to chemotherapeutic drugs. In this study, 126 cases of patients with gastrointestinal tumors admitted to hospital from February 2013 to February 2015 were selected. The expression levels of gene were obsreved in the control population and patients before and after treatment by fluoresecent quantitative PCR.

Combination of temsirolimus and adriamycin exhibits an enhanced antitumor effect in hepatocellular carcinoma.

Objective: The oncogenic PI3K/Akt/mTOR pathway is frequently activated in hepatocellular carcinoma (HCC). The aim of this study is to investigate the anti-HCC effect of combination of temsirolimus, an mTOR inhibitor, and adriamycin, a routinely used drug for treating HCC.

Methods And Materials: Proliferation of HCC cells exposure to temsirolimus, adriamycin, and their combination was determined using MTT assay in vitro as well as in a nude mice model in vivo.

Synchronous infiltrating ductal carcinoma and primary extramedullary plasmacytoma of the breast.

Background: Extramedullary plasmacytomas are seldom solitary and usually progress to diffuse myelomatosis. Plasmacytomas of the breast are rare, especially when not associated multiple myeloma. Synchronous infiltrating ductal carcinoma and primary extramedullary plasmacytoma of the breast have not previously reported.