Tumor-Selective Nano-Dispatcher Enforced Cancer Immunotherapeutic Effects via Regulating Lactate Metabolism and Activating Toll-Like Receptors.

The development of tumors relies on lactate metabolic reprogramming to facilitate their unchecked growth and evade immune surveillance. This poses a significant challenge to the efficacy of antitumor immunity. To address this, a tumor-selective nano-dispatcher, PIMDQ/Syro-RNP, to enforce the immunotherapeutic effect through regulation of lactate metabolism and activation of toll-like receptors is developed.

Research status and prospect of ratoon rice in China under mechanically harvested condition.

The proportion and area of ratoon rice planting in China have been substantially increased, due to continuous improvement of rice breeding methods and consecutive innovation of cultivation technology, which has developed into one of rice planting modes with significant production efficiency. Combining the experience in research and practice, from the perspective of crop physiology and ecology, we reviewed the current situation and prospects of high-yielding formation and physiological mechanisms of ratoon rice. We focused on four key aspects: screening and breeding of ratoon rice cultivars and the classification; suitable stubble height for mechanically harvested ratoon rice, as well as water and fertilizer management; dry matter production and allocation in ratoon rice and the relationship with yield formation; regenerative activity and vigor of ratoon rice roots and their relationship with rhizosphere micro-ecological characteristics.

Effects of nitrogen addition on rhizosphere soil properties in a salinized grassland.

We explored the impacts of nitrogen (N) inputs and the rhizosphere effect on the properties of rhizosphere and bulk soils in a salinized grassland in Northern Shanxi under N addition rates of 0, 1, 2, 4, 8, 16, 24 and 32 g N·m·a. The results showed that N addition significantly decreased soil pH, but significantly increased Ca, NO-N and inorganic nitrogen contents in rhizosphere and bulk soil. With the increases of N addition rates, the contents of Ca, NO-N, inorganic nitrogen in rhizosphere and bulk soils and total nitrogen in rhizosphere soil increased gradually, whereas the contents of Na, K, Mg, NH-N and amino acid in rhizosphere soil, and total nitrogen in bulk soil first increased and then decreased.

Anticancer activity of oleanolic acid and its derivatives modified at A-ring and C-28 position.

Oleanolic acid (OA) is a five-ring triterpenoid compound, which is widely present in plants. Due to a wide range of pharmacological activities, oleanolic acid has attracted more and more attention. However, oleanolic acid is insoluble in water and has low bioavailability, which limits its clinical application.

Graphene-based materials: A new tool to fight against breast cancer.

Breast cancer is one of the most common malignant tumors among women population on a global scale, with a huge number of new cases and deaths each year. In recent years, there has been an increasing number of literatures on the discovery and development of novel anti-breast cancer drugs and materials, aiming to increase the survival rate of breast cancer patients. One of the newest tools used for the therapy of breast cancer is graphene-based materials, which have ultra-high surface area as well as unique physical, chemical and mechanical properties.

Synthesis and biological evaluation of resveratrol derivatives with anti-breast cancer activity.

Resveratrol is a natural phytoestrogen produced by plants to protect themselves from injury, UV irradiation, and fungal attack. The main active structure is E-resveratrol, which has many pharmacological activities. As the structure of resveratrol is similar to the natural estrogen 17β-estradiol and the synthetic estrogen E-diethylstilbestrol, resveratrol is used in reducing the incidence of breast cancer.

[Prognosis-related miRNA bioinformatics screening of lung adenocarcinoma and its clinical significance].

Objective: To investigate the prognosis-related miRNA histological features and clinical significance of lung adenocarcinoma.

Methods: Using The Cancer Genome Atlas (TCGA) data, the miRNA expression profile data of human lung adenocarcinoma were searched for differential analysis, and the prognosis-related miRNAs were screened by Cox risk regression model. The targeted miRNAs were predicted by mirwalk analysis platform, KEGG functional enrichment analysis, and finally, predict the function of prognosis-related miRNAs.

Structure and Anti-HIV Activity of Betulinic Acid Analogues.

Firstly discovered in 1980s, human immunodeficiency virus (HIV) continues to affect more and more people. However, there is no effective drug available for the therapy of HIV infection. Betulinic acid existing in various medicinal herbs and fruits exhibits multiple biological effects, especially its outstanding anti-HIV activity, which has drawn the attentions of many pharmacists.

[The databases of transcription factors.].

The control of gene transcription is a critical level of gene expression regulation. The interactions between transcription factors (TF) and their DNA binding sites (TFBS) play a key role at this level. In order to decipher the molecular mechanism of the interactions of TFs with TFBSs and construct transcription regulatory network, it is necessary to systematically collect, save, and analyze the information of discovered TFs and their TFBSs.

[The action of TSG101 on HIV-1 budding and related inhibitors].

tsg101 gene is a newly found tumor suppressor gene whose product TSG101 has many important biological functions. Recent research of TSG101 has revealed that TSG101 aids HIV-1 budding from infected cells by attaching to Gag. HIV-1 budding is arrested in the cells with mutant TSG101 or without TSG101.