Publications by authors named "Hong-Fang Mei"
Article Synopsis
- Infantile hydrocephalus (IHC) is linked to various central nervous system diseases, and its genetic causes are not yet fully understood; this study focused on identifying genetic factors in IHC patients.
- The research analyzed data from 110 IHC patients who underwent exome sequencing, finding that about 15% had pathogenic variants in 13 different genes primarily associated with metabolic and brain disorders.
- The findings suggest that genetic testing is crucial for IHC patients with unclear causes, and specific genes affecting signaling pathways should be prioritized in future IHC research.
Obstructive sleep apnea hypopnea syndrome (OSAHS) is associated with the neurocognitive deficits as a result of the neuronal cell injury. Previous studies have shown that adenosine A1 receptor (ADORA1) played an important role against hypoxia exposure, such as controlling the metabolic recovery in rat hippocampal slices and increasing the resistance in the combined effects of hypoxia and hypercapnia. However, little is known about whether ADORA1 takes part in the course of neuronal cell injury after intermittent hypoxia exposure which was the main pathological characteristic of OSAHS.
View Article and Find Full Text PDFObstructive sleep apnea hypopnea syndrome (OSAHS) in children is associated with multiple system morbidities. Cognitive dysfunction as a result of central nervous system complication has been reported in children with OSAHS. However, the underlying mechanisms are poorly understood.
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