Publications by authors named "Hong-Cheng Guo"
A method to screen left ventricular dysfunction through ECG based on convolutional neural network.
J Cardiovasc Electrophysiol
April 2021
Objective: This study aims to develop an artificial intelligence-based method to screen patients with left ventricular ejection fraction (LVEF) of 50% or lesser using electrocardiogram (ECG) data alone.
Methods: Convolutional neural network (CNN) is a class of deep neural networks, which has been widely used in medical image recognition. We collected standard 12-lead ECG and transthoracic echocardiogram (TTE) data including the LVEF value.
Coptis chinensis is a widely used traditional Chinese herbal medicine. In this work, 6 new alkaloids (coptisine A-F, 1-6) and 26 known alkaloids (7-32) were isolated from the chloroform extract of the rhizomes of C. chinensis.
View Article and Find Full Text PDFCharacterization of chemical constituents and rats metabolites of an alkaloidal extract of Alstonia scholaris leaves by liquid chromatography coupled with mass spectrometry.
J Chromatogr B Analyt Technol Biomed Life Sci
July 2016
Article Synopsis
- Alstonia scholaris, a plant used in Dai ethnic medicine for treating chronic respiratory diseases, contains alkaloids as its primary bioactive components, leading to the development of an investigational drug (AAS) now in phase I/II clinical trials.
- Researchers employed an ultra-high performance liquid chromatography and mass spectrometry method to identify 35 different alkaloids in AAS, categorized into four types: scholaricine, vallesamine, picrinine, and tubotaiwine.
- The study also examined how rats metabolize these alkaloids, revealing that scholaricine-type alkaloids enter the bloodstream more easily and identifying 33 compounds in plasma and 40 in urine after administration of the extract.
Distortion of terahertz signals due to imperfect synchronization with chirped probe pulses.
J Opt Soc Am A Opt Image Sci Vis
October 2011
Terahertz (THz) signals measured by means of the spectral-encoding technique with different temporal discrepancies between probe pulses and THz signals are investigated. It is found that imperfect synchronization between the chirped probe and THz pulses induce a distortion and this distortion affects significantly the retrieved THz spectrum if the temporal discrepancy is large. The distortion becomes more prominent if the probe pulse length is less than the optimal chirped probe pulse duration.
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