Bioprinting of pre-vascularized constructs for enhancedneo-vascularization.

Pre-vascularization has been receiving significant attention for developing implantable engineered 3D tissues. While various pre-vascularization techniques have been developed to improve graft vascularization, the effect of pre-vascularized patterns onneo-vessel formation has not been studied. In this study, we developed a functional pre-vascularized construct that significantly promotes graft vascularization and conductedevaluations of the micro-vascular patterns (VPs) in various printed designs.