Publications by authors named "Hong-Bo Qiu"
Article Synopsis
- Vascular calcification (VC) involves calcium buildup in the aorta, increasing cardiovascular risks, and the study investigates the role of nesfatin-1 in this process.
- Higher levels of nesfatin-1 were found in calcified vascular smooth muscle cells (VSMCs) and patients with coronary calcification, with experiments showing it regulates VC by promoting osteogenic transformation of VSMCs.
- The study discovered that nesfatin-1 enhances BMP-2 signaling by inhibiting SYTL4, leading to changes that promote transcription of OPN, and identified compounds like Curculigoside and Chebulagic acid that reduce VC by interacting with nesfatin-1.
The role of gut microbiome in acute kidney injury (AKI) is increasing recognized. Caloric restriction (CR) has been shown to enhance the resistance to ischemia/reperfusion injury to the kidneys in rodents. Nonetheless, it is unknown whether intestinal microbiota mediated CR protection against ischemic/reperfusion-induced injury (IRI) in the kidneys.
View Article and Find Full Text PDFObjective: To investigate the protective effect of ulinastatin against myocardial injury induced by off-pump coronary artery bypass graft surgery (OPCAB).
Methods: Twenty-four patients undergoing OPCAB were randomly divided into 2 equal groups: ulinastatin group in which ulinastatin was infused intravenously, firstly at the concentration of 6000 U/kg dissolved in 50 ml normal saline for 30 min and then at the speed of 1000 U.kg(-1).