Systematic review of longitudinal studies on daily health behavior and activity of daily living among older adults.

Background: Health behavior, as an intervention led by nursing staff, plays a pivotal role in enhancing the health of older adults. However, existing evidence has predominantly focused on isolated aspects (e.g.

Preoperative optimization strategy management model applied in gallbladder surgery.

Purpose: To investigate the impact of implementing a pre-hospitalization optimization strategy on the length of stay and hospital costs for patients undergoing gallbladder surgery at a tertiary hospital, this study aims to analyze patient characteristics relevant to pre-hospitalization gallbladder surgery, focusing on age and underlying medical conditions.

Method: The data from patients who underwent the pre-hospitalization optimization strategy were analyzed and compared with that of patients receiving standard hospitalization to determine whether there were statistically significant differences in duration of stay and associated costs.

Results: Under the optimal management strategy for pre-hospitalization, we analyzed the hospitalization of patients with and without underlying diseases, specifically comparing those aged over 65 years to those under 65 years, against a cohort of general hospitalized patients.

Gestational diabetes induces autistic-like behaviors in offspring by disrupting the GABAergic system.

Background: Increasing evidence have shown that gestational diabetes mellitus (GDM) is associated with the risk of autism in offspring. However, the underlying mechanisms have not yet been fully elucidated.

Methods: A mouse model of gestational diabetes mellitus (GDM) was established to investigate its impact on offspring.

Incidence and temporal trends of out-of-hospital cardiac arrest in Shenzhen, China (2011-2018).

Background: Out-of-hospital cardiac arrest (OHCA) is a significant global public health issue, few studies describe characteristics and trends in China. This study examines OHCA features and trends in Shenzhen, one of the fastest-growing cities.

Methods: This retrospective study analysed data from the Shenzhen Emergency Center database (2011-2018), including ambulance dispatch and pre-hospital medical records.

Mitochondrial Genome Characteristics and Comparative Genomic Analysis of .

The mitochondrial genome of , an invasive species with significant ecological and economic impacts, was analyzed to provide a theoretical basis for understanding its phylogenetic relationships and molecular biology. Mitochondrial genome sequences of and 23 related species from NCBI were utilized for bioinformatics and comparative genomic analyses. A sliding window analysis identified three genes (, , and ) as potential DNA barcodes for species identification.

Genetically predicted circulating immune cells and cytokines reveal the causal role of immune factors on female infertility: a two-sample mendelian randomization study.

Objectives: Previous studies suggested that immune factors may play critical roles in female infertility, but their causal links remain unclear. To address this gap, this study employs the Mendelian randomization (MR) to delineate the causal association between circulating immune factors and female infertility.

Methods: This study employed summary-level data from three genome-wide association studies (GWAS) encompassing 731 peripheral immune cell signatures, 41 circulating cytokines, and five female infertility phenotypes to reveal the causal relationship between immune factors and female infertility.

Spatial-temporal variations of stroke mortality worldwide from 2000 to 2021.

Background: Stroke is a leading cause of premature death worldwide. Spatial-temporal characteristics are important for evidence-based stroke care planning and resource allocation. However, long-term global variations of stroke are still lacking.

Prexasertib exerts a synergistic effect on the antitumor activity of Lenvatinib through ALOX15-mediated ferroptosis in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is one of the most prevalent and lethal malignancies worldwide. Lenvatinib, a potent multi-receptor tyrosine kinase inhibitor approved for the treatment of advanced HCC, demonstrates limited clinical efficacy. Therefore, there is an urgent need to investigate therapeutic strategies that combine Lenvatinib with other anticancer agents.

Experimental Investigation on the Electrical Properties of DPPT-TT Polymer Field-Effect Transistors Featuring Stair Gate Dielectric.

P-type polymer field-effect transistors (PFETs) achieve wide applications due to their environmental compatibility and inherent flexibility. However, the dielectric in PFETs presents a vulnerability that restricts the development of the advancement of p-type power devices and power integrated circuits with high voltage in power devices. In this work, we provide a novel method that employs p-type polymer DPPT-TT high-voltage PFETs with a stair gate dielectric structure (SGD) at both the source and drain sides.

Altered Self-Referential-Related Brain Regions in Depersonalization-Derealization Disorder.

Objective: We aimed to explore the alteration in topology and network properties in self-referential-related brain regions of individuals with depersonalization-derealization disorders (DPD), using evidence from resting-state functional magnetic resonance imaging (rs-fMRI).

Methods: We first determined the regions of interest (ROIs) using Neurosynth, based on which we conducted an ROI-wise functional connectivity search to create a self-referential-related network and performed a topographical analysis. We then compared the analyzed properties from the rs-fMRI of disordered individuals to those of healthy controls to generate differential properties, based on which we conducted a machine learning-based disease diagnostic model.

Analysis of the Rate and Reasons for Discard Blood and Its Components from 2019 to 2022 in a Single Blood Service in China.

Introduction: The discard rate of blood services as a crucial quality metric for monitoring and enhancing blood safety within blood bank operations. This study investigated the prevalence and underlying causes of discarded blood and its associated components at a blood center in China.

Materials And Methods: This retrospective analysis examined data pertaining to discarded blood and its components from 2019 to 2022.

Immune imbalance in the pre-ovulatory follicular microenvironment of overweight and obese women during IVF.

Background: Overweight and obesity can induce an inflammatory milieu in the oocyte microenvironment and are closely associated with reduced assisted reproductive outcomes.

Objective: How are immune cells, cytokines and lipid profiles altered in the pre-ovulatory microenvironment of overweight and obese women?

Methods: 32 women undergoing in vitro fertilization (IVF) were included, with 14 overweight or obese (OW) and 18 normal weight (NW) participants. Serum was collected before ovulation induction, follicular fluid (FF) and aspirates were obtained during oocyte retrieval for flow cytometry, cytokines, hormone, and lipid profiles measurement.

Mechanisms of T-cell Depletion in Tumors and Advances in Clinical Research.

T lymphocytes (T cells) are essential components of the adaptive immune system that play a vital role in identifying and eliminating infected and tumor cells. In tumor immunotherapy, T cells have emerged as a promising therapeutic strategy due to their high specificity, potent cytotoxic capability, long-lasting immune memory, and adaptability within immunotherapeutic approaches. However, tumors can evade the immune system by depleting T cells through various mechanisms, such as inhibitory receptor signaling, metabolic exhaustion, and physical barriers within the tumor microenvironment.

Cardiac resynchronization therapy via left bundle branch pacing in heart failure with complete left bundle branch block: is the defibrillator needed?

Aims: This retrospective cohort study aimed to investigate the efficacy of dual-chamber left Bundle branch pacing (LBBP) as an alternative therapy for heart failure patients with complete left bundle branch block (CLBBB) and indications for defibrillator with cardiac resynchronization therapy (CRT-D).

Methods: 34 patients met inclusion criteria were enrolled in the study. These criteria included a left ventricular ejection fraction (LVEF) of lower than 35%, a New York Heart Association functional class of II-IV, CLBBB meeting Strauss's criteria, intraventricular dyssynchrony, and confirmed correction of CLBBB during LBBP.

NIPAL1 as a prognostic biomarker associated with pancreatic adenocarcinoma progression and immune infiltration.

Pancreatic adenocarcinoma (PAAD) is a highly malignant tumor in the digestive system, with an increasing incidence and mortality rate globally. Recent genetic studies have revealed that the abnormal expression and functional dysregulation of various genes are involved in the occurrence and progression of pancreatic cancer. NIPA-like proteins (NIPAs) are expressed in a variety of cancer types, yet the role of NIPAL1 in cancer remains unclear.

Expression level of miR-146a is associated with the coronary lesion severity and clinical prognosis in patients with unstable angina pectoris.

Objective: To investigate the association between plasma miR-146a expression levels, severity of coronary lesions, and clinical prognosis in patients with unstable angina pectoris (UAP).

Methods: A total of 100 patients with UAP and 100 controls were selected for assessment of plasma miRNA-146a expression levels. We assessed the severity of coronary lesions in patients with UAP using the Gensini score.

Long-Lasting Auditory and Vestibular Recovery Following Gene Replacement Therapy in a Novel Usher Syndrome Type 1c Mouse Model.

Usher syndrome type 1C (USH1C) is a genetic disorder caused by mutations in the USH1C gene, which encodes harmonin, a key component of the mechanoelectrical transduction complex in auditory and vestibular hair cells. USH1C leads to deafness and vestibular dysfunction in humans. An Ush1c knockout (KO) mouse model displaying these characteristic deficits is generated in our laboratory.

The Proximal Protonation Source in Cu-NH-C Single Atom Catalysts Selectively Boosts CO to Methane Electroreduction.

Regulating the coordination environment of active sites has proved powerful for tapping into their catalytic activity and selectivity in homogeneous catalysis, yet the heterogeneous nature of copper single-atom catalysts (SACs) makes it challenging. This work reports a bottom-up approach to construct a SAC (rGO@Cu-N(H)-C) by inlaying preformed amine coordinated Cu units into reduced graphene oxide (rGO), permitting molecular level revelation on how the proximal N-site functional groups (N-H or N-CH) impact on the carbon dioxide reduction reaction (CORR). It is demonstrated that the N-H moiety of rGO@Cu-NH-C can serve as an in situ protonation agent to accelerate the CO-to-methane reduction kinetics, delivering a methane current density (163 mA/cm) 2.

DGMSCL: A dynamic graph mixed supervised contrastive learning approach for class imbalanced multivariate time series classification.

In the Imbalanced Multivariate Time Series Classification (ImMTSC) task, minority-class instances typically correspond to critical events, such as system faults in power grids or abnormal health occurrences in medical monitoring. Despite being rare and random, these events are highly significant. The dynamic spatial-temporal relationships between minority-class instances and other instances make them more prone to interference from neighboring instances during classification.

Dysfunctional large-scale brain networks in drug-naïve depersonalization-derealization disorder patients.

Background: Depersonalization-Derealization Disorder (DPRD) presents challenges in understanding its neurobiological underpinnings. Several neuroimaging studies have revealed altered brain function and structure in DPRD. However, the knowledge about large-scale dysfunctional brain networks in DPRD remains unknown.

IBI310 plus sintilimab vs. placebo plus sintilimab in recurrent/metastatic cervical cancer: A double-blind, randomized controlled trial.

Background: It remains unclear whether adding CTLA-4 blockade to PD-1/PD-L1 blockade improves clinical outcomes in cervical cancer (CC).

Methods: In this randomized, double-blind, placebo-controlled, phase 2 study (ClinicalTrials.gov: NCT04590599), patients with recurrent/metastatic CC (R/M CC) who experienced disease progression after or during platinum-based chemotherapy were enrolled from 37 centers across China and randomly assigned (1:1), stratified by PD-L1 expression and prior treatment lines, to receive either IBI310 plus sintilimab or placebo plus sintilimab intravenously every 3 weeks for 12 weeks, followed by sintilimab alone.