Elevated basophils in peripheral blood predict lower extremity deep venous thrombosis in non-surgical patients with spontaneous intracerebral hemorrhage.

Leukocytes are associated with lower extremity deep venous thrombosis (LEDVT) in patients with spontaneous intracerebral hemorrhage (sICH). Nonetheless, the correlation between differential leukocyte subtype counts in peripheral blood and LEDVT is poorly understood. This study explored the relationship between admission basophils in leukocytes and 14-day LEDVT in non-surgical patients with sICH.

Exploration and comparison of stress hyperglycemia-related indicators to predict clinical outcomes in patients with spontaneous intracerebral hemorrhage.

Spontaneous intracerebral hemorrhage (ICH) is a prevalent hemorrhagic stroke characterized by a significant fatality rate and severe neurological impairments. Stress hyperglycemia has been confirmed to have a significant prognostic role in a range of diseases. However, studies on the association between stress hyperglycemia and the outcome of ICH have not currently been reported.

Lysyl oxidase-like 1 predicts the prognosis of patients with primary glioblastoma and promotes tumor invasion EMT pathway.

Background: Lysyl oxidase enzymes (LOXs), as extracellular matrix (ECM) protein regulators, play vital roles in tumor progression by remodeling the tumor microenvironment. However, their roles in glioblastoma (GBM) have not been fully elucidated.

Methods: The genetic alterations and prognostic value of LOXs were investigated cBioPortal.

C-reactive protein is a predictor for lower-extremity deep venous thrombosis in patients with primary intracerebral hemorrhage.

Objective: Our study aimed to determine whether there exists an association between low-grade systemic inflammation, as measured by serum C-reactive protein (CRP), and the risk of lower-extremity deep venous thrombosis (LEDVT) in patients with primary intracerebral hemorrhage (ICH).

Methods: This observational study was retrospectively conducted on patients with primary ICH who were presented to two tertiary medical centers between January 2021 and August 2022. The primary outcome was detecting LEDVT occurrence within 14 days from the onset of the acute ICH episode.

Repair abilities of mouse autologous adipose-derived stem cells and ShakeGel™3D complex local injection with intrauterine adhesion by BMP7-Smad5 signaling pathway activation.

Background: The objective was to explore the therapeutic effect of autologous adipose-derived stem cells (ADSCs) combined with ShakeGel™3D transplantation to activate the BMP7-Smad5 signaling pathway to treat intrauterine adhesions (IUA).

Methods: Autologous ADSCs were isolated and then merged with ShakeGel™3D. The IUA model was established by mechanical injury.

Epigenome-Wide Tobacco-Related Methylation Signature Identification and Their Multilevel Regulatory Network Inference for Lung Adenocarcinoma.

Tobacco exposure is one of the major risks for the initiation and progress of lung cancer. The exact corresponding mechanisms, however, are mainly unknown. Recently, a growing body of evidence has been collected supporting the involvement of DNA methylation in the regulation of gene expression in cancer cells.

[Staged retrograde flexible ureteroscopic lithotripsy versus miniaturized percutaneous nephrolithotomy for renal stones of 2-4 cm in diameter: a randomized controlled trial].

Objective: To compare the efficacy and safety of staged retrograde flexible ureteroscopic lithotripsy (FURS) and miniaturized percutaneous nephrolithotomy (m-PCNL) for treatment of renal stones of 2-4 cm in diameter.

Methods: This randomized controlled trial was conducted in 70 patients with renal stones of 2-4 cm in diameter admitted in our hospital between January 2013 and December 2015. The patients were randomized to receive staged FURS (35 cases) or m-PCNL (35 cases), and the total treatment time, total hospital stay after procedure, total medical cost, treatment success, decrease in hemoglobin level and complications were compared between the two groups.

[Design of Noninvasive Blood Constituent Spectrum Data Acquisition System Based on FPGA].

Blood constituent examination is an important means of health diagnosis. For blood constituent examination, we usually adopt the method of drawing blood, which bring pain and the risk of cross infection to the patient. Near infrared spectrum spectroscopy (NIRS) is a research hotspot in noninvasive blood constituent examination.

[The effect of MSC spectral pretreatment regions on near infrared spectroscopy calibration results].

In the present paper, 60 whole wheat flour samples were prepared and corresponding NIR spectra were collected. After the determinations of calibration range, several spectral sub-regions containing calibration range and prepared for the correction using multiple scattering correction (MSC) were obtained in the whole spectral region firstly, and MSC correction based on different spectral sub-region followed subsequently. Corresponding spectral data were obtained from the fixed calibration range of the spectra corrected based on different regions.

Complete mitochondrial genome sequence and mutations of the Glioma model inbred C57BL/6 mice strain.

In the present work we undertook the complete mitochondrial genome sequencing of an important glioma model inbred rat strain for the first time. The total length of the mitogenome was 16,308 bp. It harbored 13 protein-coding genes, 2 ribosomal RNA genes, 22 transfer RNA genes and 1 non-coding control region (D-loop region).

Pharmacokinetics of oxycodone hydrochloride and three of its metabolites after intravenous administration in Chinese patients with pain.

Objectives: The aim of this study is to evaluate the pharmacokinetic profile of oxycodone and three of its metabolites, noroxycodone, oxymorphone and noroxymorphone after intravenous administration in Chinese patients with pain.

Methods: Forty-two subjects were assigned to receive intravenous administration of oxycodone hydrochloride of 2.5, 5 or 10 mg.

[Effect of midazolam on mantle cell lymphoma JeKo-1 cell line and its relevant mechanisms].

This study was aimed to explore the effect of midazolam on mantle cell lymphoma cell line JeKo-1 and the relevant mechanisms. Effects of midazolam on the proliferation and apoptosis of JeKo-1 cells were observed by CCK8 assay and flow cytometry, respectively. Effect of midazolam on the expression of BCL-2, cytochrome C (Cyto-C), pro-caspase-9, pro-caspase-8 and pro-caspase-3 protein were detected by Western blot.

[Design of high-efficiency double compound parabolic concentrator system in near infrared noninvasive biochemical analysis].

High signal-to-noise ratio (SNR) of system is necessary to obtain accurate blood components in near infrared noninvasive biochemical analysis. In order to improve SNR of analytical system, high-efficiency double compound parabolic concentrator (DCPC) system was researched, which was aimed at increasing light utilization efficiency. Firstly, with the request of collection efficiency in near infrared noninvasive biochemical analysis, the characteristic of emergent rays through compound parabolic concentrator (CPC) was analyzed.

[Experimental study of differential spectrum method for elimination of tissue background in noninvasive biochemical detection].

In noninvasive biochemical detection, the differential spectrum method based on the change in blood volume can eliminate the interference of human tissue background in theory, and obtain effective spectrum information of blood. In order to demonstrate the effectiveness of the differential spectrum method, simulated experiment was designed. Biological molecules solutions were used for simulating serum sample, filters with different absorption characteristic were used for simulating interference of tissue background, and an adjustable path-length cell was used for simulating blood volume change.

[Near infrared spectral analysis and measuring system for primary nutrient of soil].

Soil is the foundation of agricultural production. Rapid analysis of soil nutrients, using near infrared spectral analysis technology, can guide process of agricultural production. Developing near-infrared measuring system with discrete wavelength will change the extensive operation situation of agricultural production.

Pharmacokinetics and safety of a new bioengineered thrombolytic agent, human tissue urokinase type plasminogen activator in Chinese healthy volunteers.

The aim of our study was to investigate the pharmacokinetics and safety of human tissue urokinase type plasminogen activator (HTUPA) in healthy Chinese subjects after intravenous administration. Thirty-two subjects were given intravenous injection doses of 5-35 mg of HTUPA for safety evaluation. Twenty-four subjects were given 10, 20 or 30 mg HTUPA for pharmacokinetic assessment.

[Improving the diagnostic method for the SLC25A13 gene 851del4 mutation and analysis of the common mutation frequencies in Quanzhou area].

Objective: To ascertain whether the carrier rate is high in Quanzhou which is next to Taiwan in South of the Yangtze River.

Methods: Population analysis of three SLC25A13 mutations, i.e.

Single-dose safety, pharmacokinetics, and food effects studies of compound naphthoquine phosphate tablets in healthy volunteers.

The compound naphthoquine phosphate is a novel antimalaria drug tablet containing a fixed-dose combination of naphthoquine phosphate and artemisinin in a 1:2.5 ratio. A randomized, open study on the safety and tolerability was conducted in 28 healthy male volunteers using a single oral dose of 350 mg, 700 mg, 1400 mg, or 2100 mg of artemisinin-naphthoquine phosphate.

[Choice of characteristic near-infrared wavelengths for soil total nitrogen based on successive projection algorithm].

The present paper proposed how to select characteristic near-infrared wavelength for soil total nitrogen by using successive projection algorithm (SPA). Spectral data are compressed by SPA in the first place to obtain the raw wavelengths. Then the group of wavelengths derived from SPA is screened by their contributions to the total nitrogen.