ZFP36L2 Is a Potential Prognostic Marker of IL1β Osteosarcoma.

Osteosarcoma stands as the predominant bone malignancy afflicting children and young adults. Despite strides in treatment, the enduring reality is that the long-term survival rates for patients grappling with recurrences and metastases linger at a mere 30%. This underscores the pressing demand for novel prognostic markers and therapeutic avenues to improve outcomes and offer hope to those battling this formidable disease.

Information-controlled graph convolutional network for multi-view semi-supervised classification.

Graph convolutional networks have achieved remarkable success in the field of multi-view learning. Unfortunately, most graph convolutional network-based multi-view learning methods fail to capture long-range dependencies due to the over-smoothing problem. Many studies have attempted to mitigate this issue by decoupling graph convolution operations.

XCL1-secreting CEA CAR-T cells enhance endogenous CD8 T cell responses to tumor neoantigens to confer a long-term antitumor immunity.

Background: Therapeutic efficacy of carcinoembryonic antigen (CEA)-specific chimeric antigen receptor (CAR) T cells against colorectal cancer (CRC) remains limited due to the unique characteristics and distinct microenvironments of tumor tissues. We modified CEA-specific CAR-T cells, aiming to stimulate endogenous CD8 T cell responses against neoantigens that were derived from CEA-positive tumors destroyed by the CAR T cells.

Methods: In a conventional CEA CAR (reg-CAR), we modified it to express lymphotactin XCL1 and interleukin (IL)-7 genes, constructing a modified 7XCL1-CAR.

Microplastics induce human kidney development retardation through ATP-mediated glucose metabolism rewiring.

Recent research has revealed an accumulation of microplastics (MPs) in the environment and human tissues, giving rise to concerns about their potential toxicity. The kidney is a vital organ responsible for various physiological functions. Early kidney development is crucial for ensuring proper structure and function.

Clinical analysis of infection in patients with liver cirrhosis in Beijing.

Background: The incidence of () infection in patients with cirrhosis has been increasing over recent years, posing certain difficulties in clinical treatment.

Aim: To analyze the clinical features of patients with liver cirrhosis and identify the risk factors to help the early diagnosis and treatment of these diseases.

Methods: Clinical data and laboratory tests were collected from 72 patients with cirrhosis confirmed by secretion or blood culture of infection at Beijing Ditan Hospital, Capital Medical University, between May 2016 and October 2018.

NOS inhibition sensitizes metaplastic breast cancer to PI3K inhibition and taxane therapy via c-JUN repression.

Metaplastic breast cancer (MpBC) is a highly chemoresistant subtype of breast cancer with no standardized therapy options. A clinical study in anthracycline-refractory MpBC patients suggested that nitric oxide synthase (NOS) inhibitor NG-monomethyl-l-arginine (L-NMMA) may augment anti-tumor efficacy of taxane. We report that NOS blockade potentiated response of human MpBC cell lines and tumors to phosphoinositide 3-kinase (PI3K) inhibitor alpelisib and taxane.

Research Progress on the Role of the Interleukin Family in the Pathogenesis of Cerebral Palsy in Children.

Cerebral palsy (CP), a common neurological disorder in children, remains a significant research focus. The interleukin (IL) family, pivotal mediators in inflammatory responses, shows increased expression in various neuroinflammatory diseases, markedly influencing their onset and progression. Elevated IL levels in the brains of children with CP, in contrast to healthy peers, reflect similar elevations in neurological conditions linked to CP, indicating a strong association between CP and the IL family.

Mutation of lysine-specific demethylase 5 is associated with enhanced tumor immunity and favorable outcomes in pan-cancer immune checkpoint blockade.

The lysine-specific demethylase 5 (KDM5) family, a key post-translational modification of chromatin, can shape tumor immune microenvironment. Here, we performed an extensive clinical and bioinformatic analysis to explore the association between KDM5 mutation and tumor immunity and its impact on the outcomes in pan-cancer immunotherapy. In 2943 patients across 12 tumor types treated with immune checkpoint inhibitors, KDM5-mutant tumors were associated with favorable overall survival (hazard ratio, 0.

Expert consensus on sequential surgery following conversion therapy based on combination of immune checkpoint inhibitors and antiangiogenic targeted drugs for advanced hepatocellular carcinoma (2024 edition).

Up to half of hepatocellular carcinoma (HCC) cases are diagnosed at an advanced stage, for which effective treatment options are lacking, resulting in a poor prognosis. Over the past few years, the combination of immune checkpoint inhibitors and anti-angiogenic targeted therapy has proven highly efficacious in treating advanced HCC, significantly extending patients' survival and providing a potential for sequential curative surgery. After sequential curative hepatectomy or liver transplantation following conversion therapy, patients can receive long-term survival benefits.

Discovery of a Gut Bacterial Pathway for Ergothioneine Catabolism.

Ergothioneine is a diet-derived micronutrient for humans. However, enzymes involved in the catabolism of ergothioneine in human gut bacteria have not yet been identified. Herein, we characterize a sulfidogenic pathway for gut bacterial catabolism of this micronutrient, which involves an unprecedented reductive desulfurization reaction catalyzed by members of the xanthine oxidoreductase family (XOR), a class of molybdenum-containing flavoproteins.

Concerns on the mother-to-child transmission of hepatitis B virus reported in Ethiopia.

Introduction: Taye and colleagues reported that the rate of mother-to-child transmission (MTCT) of hepatitis B virus (HBV) was as high as 20.7% in Ethiopia based on their meta-analysis of three studies [1]. However, numerous studies demonstrate that the overall rate of MTCT is below 5% after timely neonatal administration of hepatitis B immunoglobulin (HBIG) and hepatitis B vaccine after birth.

Prognostic importance of an indicator related to systemic inflammation and insulin resistance in patients with gastrointestinal cancer: a prospective study.

Background: Systemic inflammation (SI) and insulin resistance (IR) are correlated to the progression of gastrointestinal (GI) cancer. Therefore, this study aimed to analyze the potential clinical value of the C-reactive protein-triglyceride-glucose index (CTI) in relation to SI and IR in patients with GI cancer.

Methods: This prospective cohort study included patients with GI cancer.

PSA-HWT: handwritten font generation based on pyramid squeeze attention.

The generator, which combines convolutional neural network (CNN) and Transformer as its core modules, serves as the primary model for the handwriting font generation network and demonstrates effective performance. However, there are still problems with insufficient feature extraction in the overall structure of the font, the thickness of strokes, and the curvature of strokes, resulting in subpar detail in the generated fonts. To solve the problems, we propose a method for constructing a handwritten font generation model based on Pyramid Squeeze Attention, called PSA-HWT.

How different body compositions affect the prognosis of HCC undergoing immunotherapy: the paradoxical phenomenon of BMI.

Purpose: Body mass index (BMI) is associated with the prognosis of hepatocellular carcinoma (HCC) receiving immunotherapy. Body compositions are considered to account for this association, but this hypothesis has yet to be verified conclusively.

Material And Methods: Our study included 305 patients received immunotherapy at 3 centers between August 2018 and February 2022.

The preoperative hemoglobin, albumin, lymphocyte, and platelet score (HALP) as a prognostic indicator in patients with non-small cell lung cancer.

Background: The Hemoglobin, Albumin, Lymphocyte, and Platelet score (HALP) is an inflammatory nutrition-related biomarker based on hemoglobin and albumin levels, as well as the lymphocyte and platelet load index, which has been reported to be associated with the prognosis of various types of tumors. This study aims to investigate the prognostic value of HALP in patients with non-small cell lung cancer (NSCLC).

Methods: A total of 2,428 patients with NSCLC were enrolled in the INSCOC study.

Refractive Index Morphology Imaging Microscope System Utilizing Polarization Multiplexing for Label-Free Single Living Cells.

Detections of internal substances and morphologies for label-free living cells are crucial for revealing malignant diseases. With the phase serving as a coupling of refractive index (RI) (marker for substances) and thickness (morphology), existing decoupling methods mainly rely on complex integrated systems or extensive optical field information. Developing simple and rapid decoupling methods remains a challenge.

Synergistic effect evaluation method of atmospheric emission reduction based on deep learning fusion model.

Currently, the absence of a nonlinear response between air quality and industrial emissions, which accurately captures the complex relationship between pollution levels and emission sources, poses a significant challenge in the formulation of effective control policies. For the purpose of effectively managing industrial emissions and mitigating severe pollution peaks, a new method for evaluating the synergistic effects of atmospheric emission reduction was proposed. The objective of this method is to simulate the impact of emissions on air quality.

Corrigendum: Research progress of traditional Chinese medicine on the treatment of diarrhea by regulating intestinal microbiota and its metabolites based on renal-intestinal axis.

[This corrects the article DOI: 10.3389/fcimb.2024.

A Low-Cost Microfluidic Device For the On-Line Counting of Microparticle/Bacteria.

On-line counting of the microparticle/bacteria in the liquid medium has great potential in the food safety and biomedical fields. A new low-cost microfluidic device is proposed for the on-line counting of the microparticles/bacteria in the liquid medium. The gradually contracted microchannel and the viscoelastic fluid are combined to achieve the efficient elastic focusing of the particle/bacteria, which significantly improves the counting accuracy by aligning all particles/bacteria in a single position at the center of the microchannel.

Earth-Based Transmitters Trigger Precipitation of Inner Radiation Belt Electrons: Unveiling Observations and Modeling Results.

Human activity influence Earth's environment, including the space environment hundreds to thousands of kilometers above the Earth. One direct evidence is that the 19.8 kHz electromagnetic signals launched by the North West Cape (NWC) transmitter station in Australia produce a wisp-like energy distribution of precipitating energetic electrons in Earth's inner radiation belt, observed by many Low Earth Orbiting satellites.

Seed-Mediated Synthesis of High Loading PtCo Intermetallic Compounds Enhanced Catalytic Efficacy and Long-Term Stability for Oxygen Reduction Reaction.

Atomically ordered intermetallic Pt-based nanoparticles, recognized as advanced electrocatalysts, exhibit superior activity for the oxygen reduction reaction (ORR) in fuel cell cathodes. Nevertheless, the formation of these ordered structures typically necessitates elevated annealing temperatures, which can accelerate particle growth and diminished reactivity. In this study, we synthesized carbon-supported platinum-cobalt intermetallic compounds (PtCo-IMCs) with sub-4 nm particle sizes and uniform distribution.

Long-term effectiveness of the combination of iguratimod and alendronate in SAPHO syndrome: a prospective cohort study.

Objective: To evaluate the long-term effectiveness of the combination of Iguratimod (IGU) and Alendronate for patients with Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) syndrome.

Methods: A prospective cohort study was conducted on patients diagnosed with SAPHO syndrome at Peking University Third Hospital and Beijing Jishuitan Hospital from 2017 to 2024. The initial treatment regimen comprised a combination of IGU and Alendronate.