Impact of pan-cancer analysis of the exportins family on prognosis, the tumor microenvironment and its potential therapeutic efficacy.

This study aims to comprehensively analyze the role of the exportin (XPO) family in the development and progression of cancer. These nuclear transport proteins have been increasingly recognized for their involvement in oncogenic processes and tumor growth. We utilized updated public databases and bioinformatics tools to assess the expression levels of the XPO family and their associations with key oncological markers including patient survival, immune subtypes, tumor microenvironment, stemness scores, drug sensitivity, and DNA methylation across various cancers.

Relationship between gestational body mass index, blood pressure variability, and postpartum depression in pregnant women with pre-eclampsia.

Background: Pre-eclampsia has long been proven to be an independent risk factor for postpartum depression (PPD). Excessive increase in body mass index (BMI) during pregnancy is an important factor inducing pre-eclampsia. Increased blood pressure is the main symptom of patients with pre-eclampsia.

Comparison of the pocket-creation method with the conventional method of endoscopic submucosal dissection for cecal and ascending colon lesion resection.

Objective: To compare the pocket-creation method (PCM) with the conventional method of endoscopic submucosal dissection (ESD) for cecal and ascending colon lesion resection.

Methods: The data of patients who underwent ESD for cecal or ascending colon lesions were retrospectively analyzed. The patients were divided into the PCM group and the conventional group according to the method of ESD.

Effect of Edge Reconstruction on the Growth Mechanism of Black Phosphorene.

Based on our previous studies, the reconstruction of interlayer edges of black phosphorene (BP) is identified as a key factor impeding the growth of large-size BP films through the CVD method. In this study, we systematically explore the complex growth mechanisms of BP, specifically focusing on how edge reconstruction influences the growth of BP. The results reveal that BP with reconstructed edges is highly stable.

Hydroxyl-based acid-hypersensitive acetal ester bond: Design, synthesis and the application potential in nanodrugs.

Targeted drug delivery systems exploiting the acidic tumor microenvironment have been thriving, with responsive modifications to the active sites like hydroxyl groups enhancing stability, reducing toxicity, and boosting targeted bioavailability. Yet, the utility of hydroxyl-based acid-sensitive linkages is currently constrained by the intricacy of synthesis, questionable stability, and an inability to discern between physiological pH levels associated with health and disease. Here, we unveiled a novel hydroxyl-based acid-labile linkage, the "acetal ester bond", which not only excelled in its hypersensitive acid responsiveness, but was also facile to synthesize, with exceptionally high yields (>80 %) of final products derived from primary, linear secondary, cyclic secondary, and tertiary alcohols consistently, demonstrating its broad applicability.

Release of Organochlorine Pollutants from Forest Fires: 1. Emission Factors and Revisiting Their Emissions in the Himalayan Regions.

Worldwide forest fires have occurred frequently in recent years, a result of which may be the emission of so-called "legacy" organochlorine pollutants (OCPs) accumulated in forests. However, few studies have measured the emission factors (EFs) of the toxicity of the OCPs from forest fires. In this study, the EFs of vegetation burning were observed in forests along the altitudinal gradient from 1000 to 4200 m, and the EFs of ∑DDTs (dechlorodiphenylthrichloroethanes), HCB (hexachlorobenzene), ∑HCHs (hexachlorocyclohexanes), and ∑PCBs (polychlorinated biphenyls) were 2050 ± 1175, 379 ± 409, 48 ± 51, and 65 ± 59 ng/kg, respectively.

Efficacy and safety of safflower yellow combined with low molecular weight heparin in preventing deep vein thrombosis after orthopedic surgery: a systematic review and meta-analysis.

Objective: This systematic review and meta-analysis aims to evaluate the efficacy and safety of safflower yellow (SY) combined with low molecular weight heparin (LMWH) in preventing deep vein thrombosis (DVT) after orthopedic surgery.

Methods: We conducted a comprehensive investigation of PubMed, EMbase, Cochrane Library, CNKI, VIP, and Wanfang databases to identify randomized controlled trials (RCTs) from January 2000 to March 2024. These trials compared the efficacy of SY combined with LMWH versus LMWH alone in preventing post-surgical DVT.

Efficacy of initial combination with belimumab in newly diagnosed childhood-onset lupus nephritis: a single-centre historical control study.

Objective: To explore the efficacy of initial treatment of newly diagnosed childhood-onset lupus nephritis (cLN) with combination of belimumab and either cyclophosphamide, mycophenolate mofetil, tacrolimus or multitargeted therapy.

Methods: A historical control study was conducted on children aged 5-17 years with newly diagnosed cLN. All patients recruited met the 2012 Systemic Lupus International Collaborating Clinics and/or 2019 European League Against Rheumatism/American College of Rheumatology classification criteria for SLE, and the 2003 International Society of Nephrology/Renal Pathology Society histopathological criteria for LN.

[Professor 's clinical experience of acupuncture for subjective tinnitus].

This article introduces Professor 's clinical experience of acupuncture for treating subjective tinnitus. Professor advocates combining meridian differentiation, syndrome differentiation, and disease differentiation in clinical practice. For excess syndrome of subjective tinnitus, acupuncture aims to unblock the meridian and regulate and blood.

Chronic kidney disease and thyroid hormones.

Introduction: Thyroid dysfunction is prevalent in chronic kidney disease (CKD) patients and significantly impacts renal outcomes and mortality. This study investigated the associations between thyroid function and clinical outcomes, and also the therapeutic effects of thyroid hormone replacement therapy (THRT) in CKD patients.

Methods: We conducted a retrospective cohort study using data from the China Renal Data System.

Alkyl chain length-regulated intelligent nano-assemblies with AIE-active photosensitizers for photodynamic cancer therapy.

Photodynamic therapy (PDT) brings new hope for the treatment of breast cancer due to few side effects and highly effective cell killing; however, the low bioavailability of traditional photosensitizers (PSs) and their dependence on oxygen severely limits their application. Aggregation-induced emission (AIE) PSs can dramatically facilitate the photosensitization effect, which can have positive impacts on tumor PDT. To-date, most AIE PSs lack tumor targeting capability and possess poor cell delivery, resulting in their use in large quantities that are harmful to healthy tissues.

Oxymatrine relieves non-alcoholic fatty liver disease by promoting sirtuin 1/adenosine 5'-monophosphate-activated protein kinase pathway and peroxisome proliferator activated receptor alpha-mediated hepatic fatty acid oxidation.

Non-alcoholic fatty liver disease (NAFLD) is a liver disease without approved treatment. Oxymatrine (OMT) has protective effects in various liver diseases. We aimed to investigate the roles and mechanisms of OMT in NAFLD.

Fine Needle Aspiration Cytological Diagnosis of Primary Breast Large-Cell Neuroendocrine Carcinoma/Squamous Cell Carcinoma.

Primary breast large-cell neuroendocrine carcinoma (LCNEC)/squamous cell carcinoma (SCC), also referred to as mixed neuroendocrine/non-neuroendocrine neoplasms of the breast (Br-MiNENs), represents an exceedingly rare malignancy. We report the first case of primary breast LCNEC/SCC diagnosed via ultrasound-guided fine-needle aspiration (FNA) biopsy of the left supraclavicular and left internal mammary lymph nodes. The patient, a 40-year-old female, underwent a lumpectomy followed by breast-conserving surgery and was diagnosed with primary breast LCNEC.

Frailty and Self-Care Maintenance Mediated by Social Support and Depression in Older Adults With Heart Failure.

Background: Older adults with heart failure often exhibit poor self-care maintenance. Frailty could exacerbate self-care, leading to deteriorating health. Social support and depression may play a role in self-care maintenance in older adults with heart failure combined with frailty.

In vitro digestion and fecal fermentation of Tremella fuciformis exopolysaccharides from basidiospore-derived submerged fermentation.

Tremella fuciformis polysaccharides (TFPS) belong to natural bioactive macromolecule with both edible and medicinal value, possessing much bioactivities such as anti-tumor, antioxidant, antidiabetics, and immunomodulatory. Currently, the production of TFPS through submerged fermentation (TFPS-1) is gradually replacing the polysaccharides extracted from the fruiting body due to improved fermentation efficiency and reduced separation costs. However, it is still unclear about the effect of TFPS-1 on gastrointestinal digestion and gut microbial fermentation, which is directly related to the function of its biological activity.

Disulfiram Alleviates MTX-Induced Pulmonary Fibrosis by Inhibiting EMT in Type 2 Alveolar Epithelial Cells.

Purpose: Methotrexate (MTX)-induced pulmonary fibrosis is associated with high morbidity and mortality, with limited treatment options available. This study investigates whether disulfiram (DSF) can mitigate MTX-induced pulmonary fibrosis and explores the underlying mechanisms.

Methods: Eight-week-old male mice were divided into control, DSF, MTX, and MTX+DSF groups and treated for 8 weeks.

Inflammation-based scores predict chronic kidney disease progression in patients with chronic kidney disease and chronic heart failure.

Background: Inflammation is associated with adverse outcomes of chronic kidney disease (CKD) or chronic heart failure (CHF), but few large data exist. We aimed to explore the clinical associations, and prognostic consequences of inflammation-based scores in patients with CKD and CHF.

Methods: This work was a retrospective cohort study.