Imaging and Pathology Concordance in Head and Neck Cancer: Retrospective Analysis.

Background: Lymph node metastasis critically impacts prognosis in head and neck malignancies. Preoperative imaging (CT/MRI) is vital for assessment but often yields false results. This study examines the concordance between preoperative imaging and postoperative pathology and identifies factors influencing imaging accuracy.

Emergence of a metallic surface state for narrow bandgap Mott insulator SrIrO(001) thin films.

We report evidence of a finite density of states at the Fermi level at the surface of epitaxial thin films of the narrow bandgap Mott insulator SrIrO(001). The Brillouin zone critical points for SrIrO(001) thin films have been determined by a comparison of the band mapping from angle-resolved photoemission spectroscopy and low energy electron diffraction. Angle-resolved X-ray photoemission studies reveal the surface termination of SrIrO(001) is Sr-O.

Interface phenomena and emerging functionalities in ferroelectric oxide based heterostructures.

Capitalizing on the nonvolatile, nanoscale controllable polarization, ferroelectric perovskite oxides can be integrated with various functional materials for designing emergent phenomena enabled by charge, lattice, and polar symmetry mediated interfacial coupling, as well as for constructing novel energy-efficient electronics and nanophotonics with programmable functionalities. When prepared in thin film or membrane forms, the ferroelectric instability of these materials is highly susceptible to the interfacial electrostatic and mechanical boundary conditions, resulting in tunable polarization fields and Curie temperatures and domain formation. This review focuses on two types of ferroelectric oxide-based heterostructures: the epitaxial perovskite oxide heterostructures and the ferroelectric oxides interfaced with two-dimensional van der Waals materials.

High-Fidelity, High-Conductivity and Multifunctional PEDOT:PSS Hydrogel for Efficient Electromagnetic Interference Shielding and Ultrafast Response Electrochromic Applications.

Poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) hydrogel are promising for applications in electromagnetic interference (EMI) shielding, energy storage, and electrochromic (EC) devices. However, challenges such as low conductivity at reduced solid content, limited charge storage, poor mechanical properties, and structural distortion during solvent treatment limit their high-performance applications. To address these issues, a high-fidelity, high-conductivity and multifunctional PEDOT:PSS hydrogel is developed by an ice crystal-assisted skeleton stacking and stepwise treatment strategy, achieving ultrahigh conductivity of 87,249 S m at 5.

The anomalous temperature dependent low energy electron diffraction intensity at epitaxial SrIrOthin film surfaces.

We report on the temperature dependent low energy electron diffraction (LEED) studies of 12 nm epitaxial SrIrO(001) thin films. The Debye temperature has been extracted from the temperature-dependence of LEED intensity at elevated temperatures and different electron kinetic energies. For the most surface sensitive LEED, obtained at the lowest electron kinetic energies, the extracted surface Debye temperature is 270 ± 22 K, which is much lower than the 488 ± 40 K Debye temperature obtained using higher electron kinetic energies.

Metformin inhibits the growth of SCLC cells by inducing autophagy and apoptosis via the suppression of EGFR and AKT signalling.

Small cell lung cancer (SCLC) is a therapeutically challenging disease. Metformin, an effective agent for the treatment of type 2 diabetes, has been shown to have antitumour effects on many cancers, including non-small cell lung cancer (NSCLC) and breast cancer. Currently, the antitumour effects of metformin on SCLC and the underlying molecular mechanisms remain unclear.

Clinical characteristics, diagnosis, treatment, and prognosis of Atezolizumab-induced encephalitis, aseptic meningitis or meningoencephalitis.

Objective: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment and expanded the range of tumor indications. However, as the usage of this medication has increased, related adverse events are increasingly being identified. Among these, Atezolizumab-induced encephalitis, aseptic meningitis, and meningoencephalitis remain poorly understood regarding clinical features.

Effect of home environment on neuropsychiatric development in preterm infants discharged from NICU at 18 months corrected age.

Background: There have been numerous intervention studies focusing on the development of preterm infants, but there has been limited investigation into the home environment as a determinant of developmental outcomes in preterm infants. The aspects and extent to which the home environment affects the early (18 months corrected age) neuropsychological development of preterm infants are still unclear.

Aims: This study aimed to analyse the effect of the home environment on the neuropsychiatric development of preterm infants at 18 months corrected age after discharge from the neonatal intensive care unit (NICU).

A Qualitative Exploration of Emotional Experiences in Patients with Thin Endometrium Undergoing Repeated Cancellations of Frozen-Thawed Embryo Transfer Cycles.

Objective: The aim of this study was to investigate the emotional experience of patients with thin endometrium (TE) who have repeatedly cancelled their cycles due to unsuitability for embryo implantation during the endometrial preparation phase of freeze-thaw embryo transfer (FET). The overall aim is to improve management strategies and quality of life for these patients.

Methods: A descriptive phenomenological methodology was utilized to conduct in-depth, semi-structured interviews with ten patients diagnosed with TE who had experienced repeated FET cancellations between January and June 2024.

Tailoring the surface and interface structures of carbon nitride for enhanced photocatalytic self-Fenton process in pollutant degradation.

Fenton technology faces significant challenges due to external HO dependency and inadequate Fe regeneration. Constructing a photocatalytic self-Fenton system is a promising strategy, but it is hindered by slow charge dynamics and low mass transfer of reactant ions. Here, we present a multi-engineering co-modified carbon nitride (OCN) for efficient photocatalytic self-Fenton reactions.

Modulation of RuO Nanocrystals with Facile Annealing Method for Enhancing the Electrocatalytic Activity on Overall Water Splitting in Acid Solution.

RuO-based materials are considered an important kind of electrocatalysts on oxygen evolution reaction and water electrolysis, but the reported discrepancies of activities exist among RuO electrocatalysts prepared via different processes. Herein, a highly efficient RuO catalysts via a facile hydrolysis-annealing approach is reported for water electrolysis. The RuO catalyst dealt with at 200 °C (RuO-200) performs the highest activities on both oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) in acid with overpotentials of 200 mV for OER and 66 mV for HER to reach a current density of 100 mA cm as well as stable operation for100 h.

Epidemiological trends and age-period-cohort effects on ischemic stroke burden across the BRICS-plus from 1992 to 2021.

Background: Ischemic stroke, accounting for 85% of stroke cases, leads to severe disabilities and increased mortality. Its global incidence rose by 87.55% from 1990 to 2019, posing significant health and economic burdens.

CellMsg: graph convolutional networks for ligand-receptor-mediated cell-cell communication analysis.

The role of cell-cell communications (CCCs) is increasingly recognized as being important to differentiation, invasion, metastasis, and drug resistance in tumoral tissues. Developing CCC inference methods using traditional experimental methods are time-consuming, labor-intensive, cannot handle large amounts of data. To facilitate inference of CCCs, we proposed a computational framework, called CellMsg, which involves two primary steps: identifying ligand-receptor interactions (LRIs) and measuring the strength of LRIs-mediated CCCs.

Sensitive and accurate photoluminescent-multiphonon resonant Raman scattering dual-mode detection of microRNA-21 via catalytic hairpin assembly amplification and magnetic assistance.

A novel dual-mode detection method for microRNA-21 was developed. Photoluminescent (PL) and multiphonon resonant Raman scattering (MRRS) techniques were combined by using ZnTe nanoparticles as signal probes for reliable detection. The catalytic hairpin assembly (CHA) strategy was integrated with superparamagnetic FeO nanoparticle clusters (NCs) to enhance sensitivity.

Correction: DNAH11 compound heterozygous variants cause heterotaxy and congenital heart disease.

[This corrects the article DOI: 10.1371/journal.pone.

A sequential stimuli-responsive hydrogel promotes structural and functional recovery of severe spinal cord injury.

Utilizing drug-loaded hydrogels to restore nerve conductivity emerges as a promising strategy in the treatment of spinal cord injury (SCI). However, many of these hydrogels fail to deliver drugs on demand according to the dynamic SCI pathological features, resulting in poor functional recovery. Inspired by the post-SCI microenvironments, here we report a time-sequential and controllable drug delivery strategy using an injectable hydrogel responsive to reactive oxygen species (ROS) and matrix metalloproteinases (MMPs).

Association Between Blood Pressure Variation During Dialysis and Cardio-Cerebrovascular Events.

In hemodialysis patients, blood pressure variability (BPV) is associated with cardiovascular events and all-cause mortality. However, previous research has predominantly concentrated on the predialysis BPV. In contrast, intradialytic BPV, reflecting the cardiovascular regulatory function during the process of rapid clearance of volume overload, holds greater relevance to the prognosis of patients.

Association Between Time to Treatment and Outcomes of Endovascular Therapy vs Medical Management in Patients With Large Ischemic Stroke.

Background And Objectives: Randomized trials have proven the benefit of endovascular therapy (EVT) for acute large ischemic stroke. This study was to characterize the effect of time to treatment on benefit of EVT vs medical management (MM) among patients with large ischemic stroke.

Methods: This was a post hoc analysis of the Endovascular Therapy in Acute Anterior Circulation Large Vessel Occlusive Patients with a Large Infarct Core randomized trial.

Giant Modulation of Second-Harmonic Generation in CuInPS by Interfacing with MoS Atomic Layers.

Probing and manipulating the intriguing nonlinear optical responses in van der Waals (vdW) ferroelectrics offer opportunities for their applications in nanophotonics. Here, we report the observation of giant and tunable second-harmonic generation (SHG) in ferroelectric CuInPS (CIPS) and CIPS/MoS heterostructures. The results show that CIPS, ranging from multilayer to bulk-like samples, all exhibit strong SHG with giant anisotropy.

Enabling Fast Photoresponse in Hybrid Perovskite/MoS Photodetectors by Separating Local Photocharge Generation and Recombination.

Interfacing CHNHPbI (MAPbI) with 2D van der Waals materials in lateral photodetectors can suppress the dark current and driving voltage, while the interlayer charge separation also renders slower charge dynamics. In this work, we show that more than one order of magnitude faster photoresponse time can be achieved in MAPbI/MoS lateral photodetectors by locally separating the photocharge generation and recombination through a parallel channel of single-layer MAPbI. Photocurrent () mapping reveals electron diffusion lengths of about 20 μm in single-layer MAPbI and 4 μm in the MAPbI/MoS heterostructure.