Association between volume of processed plasma and total bilirubin reduction during plasma adsorption for severe liver disease.

Background: The double plasma molecular adsorption system (DPMAS) is a crucial therapeutic modality for the management of severe liver disease. Current literature reports considerable variability in the volume of processed plasma (VPP) utilized during DPMAS treatment, and there is currently no consensus on the appropriate VPP. We aimed to investigate the relationship between VPP and changes in total bilirubin levels during DPMAS treatment.

Platelet-rich plasma-derived exosomes have the novel ability to alleviate insertional Achilles tendinopathy by promoting tenogenesis in tendon stem/progenitor cells.

Insertional Achilles tendinopathy (IAT) is a highly prevalent overuse injury affecting the foot and ankle in clinical settings. Currently, the primary management approach is conservative treatment. Platelet-rich plasma-derived exosomes (PRP-Exos) effectively preserve essential growth factors and other vital components inherent in PRP, thereby optimizing overall treatment outcomes.

Psychotic symptoms in Chinese patients with somatic symptom disorder: prevalence, risk factors, and associated conditions.

Psychotic symptoms are prevalent in individuals with various mental health disorders and frequently lead to adverse outcomes. In this study, we assessed the prevalence of psychotic symptoms and its associated conditions in a large sample of Chinese patients with somatic symptom disorder (SSD), which has not been examined systemically. We recruited 899 patients with SSD.

Assessment of the efficacy of early versus delayed mobility exercise after arthroscopic rotator cuff repair.

Purpose: Rotator cuff tears were a prevalent cause of shoulder pain and impairment, often necessitating arthroscopic rotator cuff repair. The optimal timing of postoperative mobilization initiation remains a subject of debate implicating patient outcomes. Therefore, this study aimed to evaluate the effectiveness of early and delayed mobilization after arthroscopic rotator cuff repair.

Bimetallic-nitrogen-carbon aerogel Co/Ni-N-C derived from 2D ordered nanosheet arrays activate PMS-AOPs for effective antibiotic removal: performance, mechanism, and toxicity.

In recent years, peroxymonosulfate-based advanced oxidation processes (PMS-AOPs) have garnered increasing attention for their efficacy in eliminating persistent organic pollutants. Metal-nitrogen-carbon (M-N-C) materials are frequently employed as efficient catalysts for the activation of PMS, leading to the effective production of various reactive species. In this study, a novel 3D porous cobalt/nickel bimetallic-nitrogen-carbon aerogel (Co/Ni-N-C) with well-dispersed CoNi-nanosheets that enhance electron transfer and provide a large active surface area was prepared through an in situ growth and a straightforward pyrolysis procedure of 2D cobalt/nickel metal-organic framework (CoNi-MOF) which was contained by a bamboo cellulose aerogel as a precursor.

The Hypoxia-Associated High-Risk Cell Subpopulation Distinctly Enhances the Progression of Glioma.

Less-aggressive lower-grade gliomas (LGGs) frequently transform into glioblastoma (GBM). Most previous studies of gliomas have not focused on LGG-original high-risk subpopulations, which may be one of the most critical hallmarks of glioma progression. In this study, LGG samples are collected to perform single-cell sequencing (scRNA-seq) and identify a unique cell subpopulation marked by CDC20, KIF20A and PTTG1, correlating with poor survival in multiple cohorts.

NAD+ Suppresses EV-D68 Infection by Enhancing Anti-Viral Effect of SIRT1.

Enterovirus 68 (EV-D68) is a non-enveloped virus with a positive-sense single-stranded RNA genome that causes respiratory diseases and acute flaccid myelitis, posing significant threats to human health. However, an effective vaccine remains undeveloped. SIRT1, a nicotinamide adenine dinucleotide (NAD+)-dependent enzyme, plays a key role in cellular metabolism, but its interaction with NAD+ during viral infections is not well understood.

Association between lactate-to-albumin ratio and all-cause mortality in critically ill cirrhotic patients with sepsis: a retrospective analysis of the MIMIC-IV database.

Background: The impact of lactate-to-albumin ratio (LAR) on mortality of critically ill cirrhotic patients with sepsis is scant.

Methods: Critically ill cirrhotic patients with sepsis were obtained from the MIMIC-IV database (v3.0).

Huc-MSCs-derived exosomes alleviate non-alcoholic steatohepatitis by regulating macrophages polarization through miR-24-3p/STING axis.

Background: There's a scarcity of drugs effective against nonalcoholic steatohepatitis (NASH). Exosomes from Human umbilical cord mesenchymal stem cells (huc-MSCs) show potential in managing glycolipid metabolism and the immune response. Therefore, further investigations are required to explore their application in NASH and the underlying mechanisms.

Gemini surfactant stabilized zein nanoparticles: Preparation, characterization, interaction mechanism, and antibacterial activity.

To enhance the physicochemical properties of zein nanoparticles, zein complexes with two Gemini surfactants (12-3-12 and 12-4-12) were prepared using the anti-solvent method and investigated the physicochemical properties, formation mechanism and antibacterial activity. Results indicated that the optimal mass ratio between zein and Gemini surfactants was at 1:1, and the incorporation of Gemini surfactants significantly improved the surface properties of zein, reducing its surface hydrophobicity and surface tension, thereby enhancing its dispersion in aqueous media. Fluorescence spectroscopy and molecular docking experiments further elucidated the interaction mechanisms between zein and Gemini surfactant, revealing a spontaneous binding process, mainly driven by hydrophobic and hydrogen interaction, and a strong binding affinity of 12-4-12 with zein.

Case report: Multi-organ injuries induced by tislelizumab.

The use of immune checkpoint inhibitors (ICIs) often develops immune-related adverse events (irAEs). However, irAEs-induced multi-organ injuries remain a rare event. We herein report a case of multi-organ injuries induced by tislelizumab in a lung squamous cell carcinoma (LUSC) patient.

Deciphering the antioxidant capacity of common vitamins against specific reactive oxygen species by nuclear magnetic resonance.

Antioxidant studies are important for understanding oxidative stress and developing preservative techniques for food and medicine. There has been increasing interest in the study of natural antioxidants, such as vitamins, due to their biocompatibility, relatively low cost, and high antioxidant capacity. Spectroscopic tools, including fluorescence and electron spin resonance, have been developed to evaluate the antioxidant capacity.

Guided tissue regeneration with a gelatin and polycaprolactone composite membrane for repairing oral soft tissue defects: A prospective, single-blinded, randomized trial.

Statement Of Problem: Clinical trials comparing outcomes of the guided tissue regeneration membrane (TRM), fabricated from gelatin and polycaprolactone via electronspinning technology, with collagen membrane for repairing oral soft tissue defects are lacking.

Purpose: The purpose of this clinical trial was to evaluate the efficacy and safety of TRM compared with collagen membrane in reconstructing oral soft tissue defects.

Material And Methods: This prospective, single-blinded, randomized, noninferiority trial involved 48 participants with oral lesions who were randomized (1:1) into 2 groups: surgery + TRM or surgery + collagen membrane.

Association between neutrophil percentage to albumin ratio and short term prognosis of acute on chronic liver failure treated with artificial liver support system.

The impact of neutrophil percentage-to-albumin ratio (NPAR) on the outcome of acute-on-chronic liver failure (ACLF) is scant. A retrospective cohort study was conducted in patients with ACLF treated with artificial liver support system (ALSS). The ACLF was diagnosed according to the Chinese Group on the Study of Severe Hepatitis B-ACLF (COSSH ACLF) criteria.

High-efficiency, cryogenic-compatible grating couplers on an AlN-on-sapphire platform through bottom-side coupling.

Sapphire is a commonly used substrate for wide-bandgap III-nitride photonic materials. However, its relatively high refractive index results in low transmission efficiency in grating couplers. Here, we propose and demonstrate that the transmission efficiency can be significantly enhanced by bottom-side coupling.

Hyperoside mitigates PCOS-associated adipogenesis and insulin resistance by regulating NCOA2-mediated PPAR-γ ubiquitination and degradation.

Aims: Polycystic ovary syndrome (PCOS) is closely associated with metabolic disorders such as insulin resistance and obesity, but the role of adipogenesis in its pathophysiology remains unclear. This study investigates the role of adipogenesis in PCOS development and evaluates whether hyperoside (HPS), an anti-adipogenic herbal compound, can improve PCOS by inhibiting adipogenesis.

Main Methods: A combination of in vivo and in vitro models was used to assess the impact of HPS on ovarian function, insulin resistance, and adipogenesis.

Effect of light fasting diet therapy on lipid metabolism and sex hormone levels in patients with polycystic ovary syndrome combined with infertility.

Objective: To investigate the effects of light fasting diet therapy, including flaxseed powder supplementation, on lipid metabolism and sex hormone levels in patients with polycystic ovary syndrome (PCOS) combined with infertility.

Methods: A total of 104 PCOS patients with combined infertility were divided into the control group ( = 52) and intervention group ( = 52) using a random number table method. Over a two-month study period, the control group received light fasting diet therapy with rice flour as a placebo, while the intervention group received light fasting diet therapy supplemented with flaxseed powder.

High-flow nasal cannula for pre- and apneic oxygenation during rapid sequence induction intubation in emergency surgery: A systematic review and meta-analysis.

Background: Rapid sequence induction intubation (RSII) is commonly used in emergency surgeries for patients at high risk of aspiration. However, these patients are more susceptible to hypoxemia during the RSII process. High-flow nasal cannula (HFNC) oxygen therapy has emerged as a potential alternative to traditional face mask (FM) ventilation pre- and apneic oxygenation.

Burnout and its relationship with depressive symptoms in primary school teachers under the "Double Reduction" policy in China.

Background: The "Double Reduction" policy requires schools to reduce Chinese students' extracurricular activities and homework to lessen academic stress and improve mental well-being. However, there is limited research on primary school teachers' psychological well-being within the context of the "Double Reduction" policy. This study examined self-reported burnout levels of primary school teachers and investigated the relationship between burnout and depressive symptoms in the context of the "Double Reduction" policy in China.

Reinvestigation into the role of lipopolysaccharide Glycosyltransferases in protein glycosylation.

Protein glycosylation has been considered as a fundamental phenomenon shared by all domains of life. In , glycosylation of flagellins A and B with pseudaminic acid have been rigorously confirmed and shown to be essential for flagella assembly and bacterial colonization. In addition to flagellins, several other proteins including RecA, AlpA/B, and BabA/B in have also been reported to be glycosylated and to be dependent on the lipopolysaccharide (LPS) biosynthetic pathway.

Appendectomy and the risk of microscopic colitis - A systematic review and meta-analysis.

Background: Microscopic colitis (MC), a chronic intestinal inflammatory disorder characterised by persistent watery diarrhoea, is categorised into collagenous and lymphocytic subtypes. Recent studies suggest that appendectomy influences the risk of MC, although the evidence remains inconclusive. This meta-analysis of available research was conducted to clarify the relationship between appendectomy and MC risk.

[Expert consensus on ethical requirements for artificial intelligence (AI) processing medical data].

As artificial intelligence technology rapidly advances, its deployment within the medical sector presents substantial ethical challenges. Consequently, it becomes crucial to create a standardized, transparent, and secure framework for processing medical data. This includes setting the ethical boundaries for medical artificial intelligence and safeguarding both patient rights and data integrity.

Xalnesiran with or without an Immunomodulator in Chronic Hepatitis B.

Background: Xalnesiran, a small interfering RNA molecule that targets a conserved region of the hepatitis B virus (HBV) genome and silences multiple HBV transcripts, may have efficacy, with or without an immunomodulator, in patients with chronic HBV infection.

Methods: We conducted a phase 2, multicenter, randomized, controlled, adaptive, open-label platform trial that included the evaluation of 48 weeks of treatment with xalnesiran at a dose of 100 mg (group 1), xalnesiran at a dose of 200 mg (group 2), xalnesiran at a dose of 200 mg plus 150 mg of ruzotolimod (group 3), xalnesiran at a dose of 200 mg plus 180 μg of pegylated interferon alfa-2a (group 4), or a nucleoside or nucleotide analogue (NA) alone (group 5) in participants with chronic HBV infection who had virologic suppression with NA therapy. The primary efficacy end point was hepatitis B surface antigen (HBsAg) loss (HBsAg level, <0.

Utilizing liquid-liquid biopolymer regulators to predict the prognosis and drug sensitivity of hepatocellular carcinoma.

Background: Liquid-liquid phase separation (LLPS) is essential for the formation of membraneless organelles and significantly influences cellular compartmentalization, chromatin remodeling, and gene regulation. Previous research has highlighted the critical function of liquid-liquid biopolymers in the development of hepatocellular carcinoma (HCC).

Methods: This study conducted a comprehensive review of 3,685 liquid-liquid biopolymer regulators, leading to the development of a LLPS related Prognostic Risk Score (LPRS) for HCC through bootstrap-based univariate Cox, Random Survival Forest (RSF), and LASSO analyses.

Wild-Type and rtA181T/sW172* Mutant Strains of Hepatitis B Virus Drive Hepatocarcinogenesis via Distinct GRP78-Mediated ER Stress Pathways.

Glucose-regulated protein 78 kDa (GRP78), a key marker of endoplasmic reticulum stress (ERS), is upregulated in hepatocellular carcinoma (HCC) tissues, but its role in hepatitis B virus (HBV)-induced tumorigenesis remains unclear. This study aimed to investigate the contribution of GRP78 to HBV-associated tumor development and explore the ERS pathways involved. The results showed that increased GRP78 expression in patients with HBV-related HCC was associated with a poor prognosis within the first 2 years following diagnosis.