Uncovering the mechanism of troglitazone-mediated idiosyncratic drug-induced liver injury with individual-centric models.

Idiosyncratic drug-induced liver injury is a rare and unpredictable event. Deciphering its initiating-mechanism is a hard task as its occurrence is individual dependent. Thus, studies that utilize models that are not individual-centric might drive to a general mechanistic conclusion that is not necessarily true.

The cost of delivering COVID-19 vaccines in Vietnam.

Background: The COVID-19 pandemic affected hundreds of millions of people and lives, and vaccination was the safest and most effective strategy to prevent and mitigate the burden of this disease. The implementation of COVID-19 vaccination in Vietnam in 2021 was unprecedentedly challenging in scale and complexity, yet economic evidence on the cost of delivery vaccines thought the program was lacking.

Methods: This retrospective costing study utilized a bottom-up, ingredient-based approach to estimate the cost of delivering COVID-19 vaccines in Vietnam in 2021, from a payer perspective.

Exploiting the predictive power of educated spheroids to detect immune-mediated idiosyncratic drug-induced liver injury: the case of troglitazone.

Idiosyncratic drug-induced liver injury (iDILI) is a major concern in drug development because its occurrence is unpredictable. Presently, iDILI prediction is a challenge, and cell toxicity is observed only at concentrations that are much higher than the therapeutic doses in preclinical models. Applying a proprietary cell educating technology, we developed a person-dependent spheroid system that contains autologous educated immune cells that can detect iDILI risk at therapeutic concentrations.

Investigation of Al(TfO)-based deep eutectic solvent electrolytes for aluminium-ion batteries. Part I: understanding the positively charged Al complex formation.

Aluminium-ion batteries (AIB) are very attractive energy storage systems due to the high availability and theoretical energy density of metallic aluminium. However, the practical performance of AIBs in AlCl-based electrolytes is limited by the low reversible capacity of the positive graphite electrode for large AlCl anions. Moreover, the use of high energy oxide-based electrodes such as MnO requires the presence of positively charged aluminium complexes in the electrolyte.

Intensification of Photobiocatalytic Decarboxylation of Fatty Acids for the Production of Biodiesel.

Light-driven biocatalytic processes are notoriously hampered by poor penetration of light into the turbid reaction media. In this study, wirelessly powered light-emitting diodes are found to represent an efficient and scalable approach for process intensification of the photobiosynthetic production of diesel alkanes from renewable fatty acids.

Pertussis vaccination during pregnancy in Vietnam: Results of a randomized controlled trial Pertussis vaccination during pregnancy.

A pertussis vaccination during pregnancy has recently been adopted in several countries to indirectly protect young infants. This study assessed the effect of adding a pertussis component to the tetanus vaccination, in the pregnancy immunization program in Vietnam. A randomized controlled trial was performed.

Coverage of the expanded program on immunization in Vietnam: Results from 2 cluster surveys and routine reports.

Unlabelled: The Expanded Program on Immunization (EPI) in Vietnam began in 1981 and reached a 87% national coverage rate in 1987. To investigate the vaccination coverage and trends in time of the EPI in Vietnam, 2 vaccine coverage cluster surveys have been conducted in 2003 and 2009. Information on EPI-vaccine coverage in children (aged 0-23 months - 7 y of age), in women of childbearing age and in pregnant women, was collected through '30 cluster surveys' in 2003 and 2009 (according to the World Health Organization (WHO) methodology) and through routine annual EPI coverage reports for the period 2001-2008.