Efficient and generalizable prediction of molecular alterations in multiple cancer cohorts using H&E whole slide images.

Molecular testing of tumor samples for targetable biomarkers is restricted by a lack of standardization, turnaround-time, cost, and tissue availability across cancer types. Additionally, targetable alterations of low prevalence may not be tested in routine workflows. Algorithms that predict DNA alterations from routinely generated hematoxylin and eosin (H&E)-stained images could prioritize samples for confirmatory molecular testing.

Targeting nucleus pulposus cell death in the treatment of intervertebral disc degeneration.

Background: Intervertebral disc degeneration (IDD) is a progressive age-related disorder characterized by the reduction in the number of nucleus pulposus cells (NPCs) and degradation of extracellular matrix (ECM), thereby leading to chronic pain and disability. The pathogenesis of IDD is multifaceted, and current therapeutic strategies remain limited. The nucleus pulposus (NP), primarily composed of NPCs, proteoglycans, and type II collagen, constitutes essential components for maintaining intervertebral disc (IVD) function and spinal motion.

Engineering Programmable Electroactive Living Materials for Highly Efficient Uranium Capture and Accumulation.

Uranium is the primary fuel for nuclear energy, critical for sustainable, carbon-neutral energy transitions. However, limited terrestrial resources and environmental risks from uranium contamination require innovative immobilization and recovery solutions. In this work, we present a novel uranium recovery method using programmable electroactive living materials (ELMs).

The Role of Endothelial L-PGDS in the Pro-Angiogenic and Anti-Inflammatory Effects of Low-Dose Alcohol Consumption.

Light alcohol consumption (LAC) may reduce the incidence and improve the prognosis of ischemic stroke. Recently, we found that LAC promotes cerebral angiogenesis and inhibits early inflammation following ischemic stroke. In addition, LAC upregulates lipocalin-type prostaglandin D2 synthase (L-PGDS) in the brain.

Eosinophilic gastroenteritis with hemorrhagic ascites: a case report.

Eosinophilic gastroenteritis (EGE) is an inflammatory disease characterized by a significant increase in eosinophils. EGE itself is rare, and cases with clinical manifestations of hemorrhagic ascites are even rarer, which undoubtedly increases the risk of misdiagnosis. Given this, this study reports a rare case of pediatric EGE presenting with paroxysmal abdominal pain without apparent cause, accompanied by acute tonsillitis and mesenteric lymphadenitis, suggesting a possible intestinal infection.

Longitudinal Model Shifts of Machine Learning-Based Clinical Risk Prediction Models: Evaluation Study of Multiple Use Cases Across Different Hospitals.

Background: In recent years, machine learning (ML)-based models have been widely used in clinical domains to predict clinical risk events. However, in production, the performances of such models heavily rely on changes in the system and data. The dynamic nature of the system environment, characterized by continuous changes, has significant implications for prediction models, leading to performance degradation and reduced clinical efficacy.

Advancing poliovirus eradication: lessons learned from piloting direct molecular detection of polioviruses in high-risk and priority geographies.

Unlabelled: In the Global Polio Laboratory Network (GPLN), poliovirus (PV) screening results from acute flaccid paralysis (AFP) surveillance is based on virus isolation (VI) through cell culture, entailing long turnaround times and the amplification of live poliovirus. An alternative Direct Detection strategy (DD-ITD) for screening viral nucleic acid from stools, bypassing the need for virus culture, has been developed and extensively validated by GPLN partners. A multi-laboratory demonstration project was conceived to field-test the DD-ITD method by GPLN laboratories from the WHO African, Western Pacific, and Eastern Mediterranean regions, where wild serotype 1 or vaccine-derived polioviruses still circulate.

Users' Willingness to Adopt Health Information in WeChat Public Platform of China.

Background: WeChat public platform has become an important source for the public to obtain health information. We aimed to explore the key factors affecting users' willingness to adopt health information and their action mechanisms.

Methods: From April 2023 to May 2023, the users of WeChat public platforms were surveyed via online questionnaires, and the factors influencing users' willingness to adopt health information and their action mechanisms were analyzed using quantitative statistics and structural equation model (SEM).

Inhibiting autophagy further promotes Ginkgolide B's anti-osteoclastogenesis ability.

Excessive osteoclast activity could cause skeletal diseases including osteoporosis. Additionally, autophagy plays an initial role in osteoclast differentiation and function. Ginkgolide B (GB), a key compound in Ginkgo biloba, improves bone mass and suppresses mature osteoclast formation in vitro.

Effects of Different Types and Ratios of Dry Tea Residues on Nutrient Content, Rumen Fermentation, and the Bacterial Community of Ensiled Sweet Sorghum.

Dry tea residue is a byproduct generated during the production, processing, and storage of tea leaves. The active ingredients and microbial composition of dried tea residue vary depending on different tea processing techniques. This study investigated the effects of six processed dry tea residues-green tea (G), black tea (B), raw Pu'er tea (Z), white tea (W), and ripe Pu'er tea (D)-at two addition ratios (5% and 10%) on the nutritional composition, fermentation quality, fermentation, and bacterial community of sweet sorghum () in the ensiling process.

Development and Validation of an Instrument to Measure Career Decision-Making Challenges of International Medical Students in China.

Introduction: International medical students (IMSs) experience various problems preventing them from making career decisions. Assessing the difficulties involved in the career decision-making process is instrumental for identifying the sources of their career indecision, which may assist them in making more informed career decisions. This study aims to develop and validate an instrument to measure career decision-making challenges of IMSs in China, who are mainly from low- and middle-income countries.

Effect of Remimazolam- Vs Propofol-Based Intravenous Anesthesia on Surgical Stress Response and Post-Operative Immune Function in Patients with Gastric Radical Surgery.

Purpose: This study aimed to compare the impact of remimazolam-based versus propofol-based intravenous anesthesia on surgical stress and post-operative immune function in patients undergoing gastric radical surgery.

Patients And Methods: Sixty-eight patients aged 50 to 80 undergoing gastric radical surgery were randomly assigned to the remimazolam group (group R) or the propofol group (group P), receiving remimazolam or propofol-based intravenous anesthesia, respectively. The primary outcome measured was peri-operative serum stress indicators and lymphocyte subtypes.

Crystalline/Amorphous Interface Engineering and d-sp Orbital Hybridization Synergistically Boosting the Electrocatalytic Performance of PdCu Bimetallene toward Formic Acid-Assisted Overall Water Splitting.

Advanced electrocatalysts capable of bifunctional catalysis for formic acid oxidation (FAOR) and hydrogen evolution reaction (HER) have garnered significant attention due to their exceptional energy efficiency. In this research, we have meticulously designed a PdCu bimetallene characterized by numerous crystalline/amorphous (c/a) interfaces and robust d-sp orbital hybridization, achieved by integrating the p-block metalloid boron within the PdCu matrix (B-PdCu-c/a). The B-PdCu-c/a bimetallene revealed a multitude of surface atoms and unsaturated defect sites, offering abundant catalytic active sites and an optimized electronic structure.

Biodegradable exosome-engineered hydrogels for the prevention of peritoneal adhesions via anti-oxidation and anti-inflammation.

Peritoneal adhesions (PA) are a common and severe complication after abdominal surgery, impacting millions of patients worldwide. The use of anti-adhesion materials as physical barriers is an effective strategy to prevent postoperative adhesions. However, the local inflammatory microenvironment exerts a significant impact on the efficacy of anti-adhesion therapies.

Ambient air pollution and hospital admission for interstitial lung diseases: A multicenter hospital-based case-crossover study.

Interstitial lung diseases (ILDs) lead to increased morbidity and premature deaths, imposing a significant burden on public health worldwide. Recently, several studies have linked ambient air pollution with the acute exacerbation of certain ILDs, but the evidence remains limited and inconclusive. With a multicenter hospital-based case-crossover design, we investigated 9128 patients who resided in Jiangsu province, China, and were admitted for ILDs between 2019 and 2022.

Diet quality during pregnancy, adolescent brain morphology, and cognitive performance in a population-based cohort.

Background: Diet quality during pregnancy may affect offspring's neurobiology and cognitive performance in childhood. However, little is known about underlying mechanisms and potential long-term effects.

Objectives: To examine associations of diet quality during pregnancy with offspring pre- and early-adolescent brain morphology and to investigate whether brain morphology mediates associations of diet quality during pregnancy with full-scale intelligence quotient (IQ) in early adolescence.

A multi-center big-data approach for precise PICC-RVT prognosis and identification of major risk factors in clinical practice.

Background: The Peripherally Inserted Central Catheter (PICC) is a widely used technique for delivering intravenous fluids and medications, especially in critical care units. PICC may induce venous thrombosis (PICC-RVT), which is a frequent and serious complication. In clinical practice, Color Doppler Flow Imaging (CDFI) is regarded as the gold standard for diagnosing PICC-RVT.

Fabricating an advanced electrogenic chassis by activating microbial metabolism and fine-tuning extracellular electron transfer.

Exploiting electrogenic microorganisms as unconventional chassis hosts offers potential solutions to global energy and environmental challenges. However, their limited electrogenic efficiency and metabolic versatility, due to genetic and metabolic constraints, hinder broader applications. Herein, we developed a multifaceted approach to fabricate an enhanced electrogenic chassis, starting with streamlining the genome by removing extrachromosomal genetic material.

Korean nurses' knowledge, opinions and current practice of trauma-informed pediatric nursing care in South Korea: a descriptive study.

Purpose: This study aimed to investigate the knowledge, opinions, competence, and barriers of nurses providing trauma-informed care (TIC) to children in hospitals.

Methods: Data were collected from 198 nurses nationwide using the TIC Provider Survey developed by the Center for Pediatric Traumatic Stress in July, 2024. Descriptive statistics, t tests, and one-way ANOVA were conducted using the IBM SPSS Statistics software (ver.

Predicting the Invasion Risk of the Highly Invasive in Asia under Global Climate Change.

, among the 100 worst invasive weeds worldwide, negatively impacts native biodiversity, agriculture, and natural ecosystems. Global climate change, characterized by rising temperatures and altered precipitation patterns, enhances the risk of invasion in Asia, making it crucial to identify high-risk areas for effective management. This study performed species distribution modeling using the maximum entropy (MaxEnt) algorithm to predict the potential introduction and spread of under various climate scenarios based on shared socio-economic pathways (SSP2-4.