Publications by authors named "Hong Shi"

To investigate the effectiveness of cap-assisted endoscope synchronous advancement and tube direction adjustment for inserting transnasal ileus tubes in patients with malignant adhesive bowel obstruction (MABO). 25 patients with cap-assisted endoscopic synchronous method (Group A, Dec 2023-Apr 2024) were reviewed retrospectively. Accordingly, those with forceps-grasping method (Group B: 27, Aug 2022-Nov 2023) were included as controls.

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Background: Peroral endoscopic myotomy (POEM) has been widely performed as a standard treatment for achalasia; however, its efficacy and safety for treating distal esophageal segmental spasms induced by cancer metastasis remain unknown.

Case Summary: A 72-year-old male was referred to our hospital and complained of progressive dysphagia for two years. Endoscopy revealed a 2 cm long segment esophageal stenosis with intact mucosa and normal cardia.

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  • Existing research indicates that factors such as the number, angle, and depth of heat pipes (HPs) significantly influence temperature distribution in coal gangue dumps, but optimal HP arrangement remains underexplored.
  • This study analyzes the impact of HP layout on temperature fields within coal gangue dumps through numerical simulations and experiments, leading to the identification of an optimal layout that enhances heat dissipation.
  • Findings reveal that decreasing HP insertion spacing and increasing insertion depth results in a reduction of both the spontaneous combustion danger zone and maximum temperature, with optimal cooling effects achieved at 3m spacing and 7m depth.
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Untargeted metabolomics can be used for the comprehensive analysis of metabolite profiles in biological samples without preset targets, making them particularly suitable for exploring metabolic characteristics and potential mechanisms in complex diseases. Therefore, in this study, we employed gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) techniques to analyze the serum metabolic characteristics of patients with pregnancy-associated venous thromboembolism (PA-VTE). In this study, 11 pregnant women with VTE and 11 healthy pregnant women were included in the experimental and control groups, respectively.

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  • The study aimed to evaluate a co-management approach for diabetes patients at the community level and its effects on treatment compliance, diagnosis, and diabetic retinopathy outcomes.
  • A total of 80 patients were divided into a control group using conventional management and a management group utilizing a community diabetes management team model, with several health indicators compared between the two.
  • Results showed significantly better treatment compliance and improved health metrics (e.g., lower blood glucose and blood pressure) in the management group, indicating that the community-based approach enhances patient management and care satisfaction.
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This study aims to investigate the associations of caring for grandchildren and/or great-grandparents with depressive symptoms, as well as life satisfaction in Chinese grandparents, and analyze the moderating roles of urban-rural residence and social participation. A nationally representative sample of 2973 grandparents in families with great-grandparents and grandchildren were selected from the 2018 China Health and Retirement Longitudinal Study (CHARLS). The Center for Epidemiologic Studies Depression (CESD-10) and the single-item were used to measure depressive symptoms and life satisfaction.

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Glioblastoma (GBM) cells have the potential to switch from being "proliferative cells" to peritumoral "invasive cells". Peritumoral GBM cells have highly invasive properties that allow them to survive surgery, leading to recurrence. The mechanisms underlying the manner in which the tumor microenvironment (TME) regulates the invasiveness of GBM remain unclear.

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  • Exposure to ultraviolet (UV) light is a known trigger for inflammation in systemic lupus erythematosus (SLE), but the specific cells involved in this response and how UV exposure interacts with interferons are not fully understood.
  • This study utilized a murine model of lupus, comparing responses in NZM2328 mice and iNZM mice with a type I interferon receptor knockout, as well as wild-type BALB/c mice, to investigate the effects of different UV treatments.
  • Findings showed that myeloid cells, particularly neutrophils and monocyte-derived dendritic cells, play a key role in the inflammatory response to UV exposure in lupus-prone mice, emphasizing the potential for targeting type I interferons and
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  • This study explores the link between malnutrition and early childhood caries (ECC) in children aged 3-5 years, aiming to support prevention strategies for both issues.
  • Involvement included 635 children from six kindergartens in Zhao Xian, China, where dental health, anthropometric measurements, and parental questionnaires were used to gather relevant data.
  • Findings indicated that underweight children faced a significantly higher risk of ECC and caries severity, while overweight and obese children had a lower risk, suggesting a complex relationship between nutritional status and dental health.
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  • Early childhood caries (ECC) is a significant issue for pediatric dentists globally, and dietary factors can influence its development, particularly in Chinese diets, which are under-researched in this context.
  • A study conducted in 2022 analyzed 155 children aged 3-5 years, classifying them based on caries status and activity, and used a mobile app to gather dietary intake data.
  • Results indicated that higher cholesterol intake is linked to an increased risk of ECC and severe cases, while iron intake may reduce this risk, suggesting that modifying dietary habits could help manage ECC among young children.
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Tobacco flavor, an important tobacco additive, is an essential raw material in cigarette production that can effectively improve the quality of tobacco products, add aroma and taste, and increase the suction flavor. The quality consistency of tobacco flavors affects the quality stability of branded cigarettes. Therefore, the quality control of tobacco flavors is a major concern for cigarette and flavor manufacturers.

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Background: OX40 has been widely studied as a target for immunotherapy with agonist antibodies taken forward into clinical trials for cancer where they are yet to show substantial efficacy. Here, we investigated potential mechanisms of action of anti-mouse (m) OX40 and anti-human (h) OX40 antibodies, including a clinically relevant monoclonal antibody (mAb) (GSK3174998) and evaluated how isotype can alter those mechanisms with the aim to develop improved antibodies for use in rational combination treatments for cancer.

Methods: Anti-mOX40 and anti-hOX40 mAbs were evaluated in a number of in vivo models, including an OT-I adoptive transfer immunization model in hOX40 knock-in (KI) mice and syngeneic tumor models.

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  • The study aimed to assess the accuracy and clinical effects of robot-assisted surgery for placing screws in patients with posterior pelvic ring fractures.
  • Data from 24 patients, mostly middle-aged, showed that the robotic method resulted in high placement precision and favorable outcomes.
  • Results indicated significant fracture healing and functional recovery, highlighting the efficacy and safety of robotic assistance in orthopedic procedures for this type of injury.
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  • Researchers developed a new small molecule antiviral called PAV-431 that was discovered through a unique screening method targeting viral protein assembly.
  • This compound has shown effectiveness against various respiratory viruses in laboratory studies and in animal models, including coronaviruses and paramyxoviruses.
  • PAV-431 works by selectively targeting a modified protein complex involved in the viral life cycle, providing a potential new approach for treating respiratory viral infections without harming the host.
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  • The study investigated the link between body mass index (BMI) and postoperative nausea and vomiting (PONV) in patients undergoing thoracic surgery for lung cancer, focusing on the first 48 hours post-surgery.
  • A total of 194 patients were analyzed, revealing that those with a high BMI (≥ 25 kg/m²) experienced significantly lower rates of PONV compared to those with a normal BMI (18.5-25 kg/m²).
  • Additionally, the research found higher levels of certain inflammatory factors in normal BMI patients, suggesting a need for greater PONV prevention in this group after surgery.
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Mouse embryonic stem cells (mESCs) sporadically transition to a transient totipotent state that resembles blastomeres of the two-cell (2C) embryo stage, which has been proposed to contribute to exceptional genomic stability, one of the key features of mESCs. However, the biological significance of the rare population of 2C-like cells (2CLCs) in ESC cultures remains to be tested. Here we generated an inducible reporter cell system for specific elimination of 2CLCs from the ESC cultures to disrupt the equilibrium between ESCs and 2CLCs.

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Background: The erector spinae plane block (ESPB) is a new analgesic method used in thoracic surgery. However, few studies have characterized their effects on perioperative opioid consumption. We aimed to evaluate the effects of ESPB on perioperative opioid consumption in patients who underwent video-assisted thoracoscopic surgery (VATS).

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Aging is associated with a decline in cardiac function. Exercise has been shown to effectively reduce the risks of cardiovascular diseases. Here whether a combination of endurance and resistance exercises can improve cardiac function in aged mice during late life is investigated.

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Aim: To investigate the underlying mechanism of dry environment (autumn dryness) affecting the lacrimal glands in rats.

Methods: Twenty Sprague-Dawley rats were randomly divided into two groups. The rats were fed in specific pathogen free environment as the control group (=10), and the rats fed in dry environment as the dryness group (=10).

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Histone deacetylase (HDAC) 9 is a negative regulator of adipogenic differentiation, which is required for maintenance of healthy adipose tissues. We reported that expression is upregulated in adipose tissues during obesity, in conjunction with impaired adipogenic differentiation, adipocyte hypertrophy, insulin resistance, and hepatic steatosis, all of which were alleviated by global genetic deletion of . Here, we developed a novel transgenic (TG) mouse model to test whether overexpression of is sufficient to induce adipocyte hypertrophy, insulin resistance, and hepatic steatosis in the absence of obesity.

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The Health and Environmental Sciences Institute (HESI) Cardiac Safety Committee designed and created a publicly accessible database with an initial set of 128 pharmacologically defined pharmaceutical agents, many with known cardiotoxic properties. The database includes specific information about each compound that could be useful in evaluating hypotheses around mechanisms of drug-induced cardiac toxicity or for development of novel cardiovascular safety assays. Data on each of the compounds was obtained from published literature and online sources (e.

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Background: Malnutrition is a common geriatric syndrome that is closely associated with adverse clinical outcomes and poses significant harm to older adults. Early assessment of nutritional status plays a crucial role in preventing and intervening in cases of malnutrition. However, there is currently a lack of measurable methods and biomarkers to evaluate malnutrition in older adults accurately.

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