Clinical efficacy and biomarker analysis of dual PD-1/CTLA-4 blockade in recurrent/metastatic EBV-associated nasopharyngeal carcinoma.

Single-agent checkpoint inhibitor (CPI) activity in Epstein-Barr Virus (EBV) related nasopharyngeal carcinoma (NPC) is limited. Dual CPI shows increased activity in solid cancers. In this single-arm phase II trial (NCT03097939), 40 patients with recurrent/metastatic EBV-positive NPC who failed prior chemotherapy receive nivolumab 3 mg/kg every 2 weeks and ipilimumab 1 mg/kg every 6 weeks.

Structural and Scintillation Properties of Ce:GdAlGaO Translucent Ceramics Prepared by One-Step Sintering.

Cerium-doped gadolinium aluminum gallium garnet (Ce:GdAlGaO, Ce:GAGG) ceramic is a promising scintillation material. In this study, Ce:GdAlGaO scintillation ceramics were prepared by the one-step sintering of commercially available GdO, AlO, GaO, and CeO powders in a flowing oxygen atmosphere at 1600 °C by solid-phase reaction sintering. For all the Ce:GdAlGaO ceramic samples doped with different amounts of Ce doping, dense ceramics were obtained.

Single-Atom Catalysts in Environmental Engineering: Progress, Outlook and Challenges.

Recently, single-atom catalysts (SACs) have attracted wide attention in the field of environmental engineering. Compared with their nanoparticle counterparts, SACs possess high atomic efficiency, unique catalytic activity, and selectivity. This review summarizes recent studies on the environmental remediation applications of SACs in (1) gaseous: volatile organic compounds (VOCs) treatment, NO reduction, CO reduction, and CO oxidation; (2) aqueous: Fenton-like advanced oxidation processes (AOPs), hydrodehalogenation, and nitrate/nitrite reduction.

Clinical Characteristics, Treatment, and Outcomes of Peritoneal Strumosis: A Report of Three Cases and Systematic Review.

Benign struma ovarii (SO) has a probability of metastasis named "peritoneal strumosis", which is extremely rare, such that the specific clinical characteristics, treatment options, and survival outcomes remain unclear. We screened three cases of peritoneal strumosis among 229 cases of SO treated in our hospital. Case 1 was a 36-year-old woman with extensive peritoneal seedings at initial presentation.

Few-Shot Partial Multi-View Learning.

It is often the case that data are with multiple views in real-world applications. Fully exploring the information of each view is significant for making data more representative. However, due to various limitations and failures in data collection and pre-processing, it is inevitable for real data to suffer from view missing and data scarcity.

Whole-tumor histogram analysis of apparent diffusion coefficient maps with machine learning algorithms for predicting histologic grade of sinonasal squamous cell carcinoma: a preliminary study.

Purpose: Accurate histologic grade assessment is helpful for clinical decision making and prognostic assessment of sinonasal squamous cell carcinoma (SNSCC). This research aimed to explore whether whole-tumor histogram analysis of apparent diffusion coefficient (ADC) maps with machine learning algorithms can predict histologic grade of SNSCC.

Methods: One hundred and forty-seven patients with pathologically diagnosed SNSCC formed this retrospective study.

Electrically switchable multicolored filter using plasmonic nanograting integrated with liquid crystal for optical storage and encryption.

This study proposed the synergistic merging of twisted-nematic liquid crystals (LCs) and nanograting embedded etalon structures for plasmonic structure color generation, realizing dynamic multifunctional metadevices. Metallic nanogratings and dielectric cavities were designed to provide color selectivity at visible wavelengths. Meanwhile, the polarization for the transmission of light could be actively manipulated by electrically modulating these integrated LCs.

Ovarian epithelioid malignant peripheral nerve sheath tumor with EWSR1-CREM fusion: A case report and literature review.

Epithelioid malignant peripheral nerve sheath tumor (EMPNST) is a rare soft tissue sarcoma. The authors report the first case of EMPNST arising in the ovary (OEMPNST). A 7-year-old child underwent left salpingo-oophorectomy due to tumor rupture and the pathology suggested a juvenile granulosa cell tumor (JGCT).

Development of an Anthropomorphic Soft Manipulator with Rigid-Flexible Coupling for Underwater Adaptive Grasping.

Inspired by human hands and wrists, an anthropomorphic soft manipulator (ASM) driven by water hydraulics is proposed for underwater operations and exploration. Compared with traditional rigid manipulator, ASM has highly evolved grasping ability with better flexibility and adaptability, while it has better load capacity, grasping ability, and flexibility in comparison with the pneumatic gripper. ASM wrist is composed of rigid-flexible coupling structure with three bellows and a spindle, which generates continuous wrist pitching.

Synthesis and Bioactivity Evaluation of Nepetaefolin F and Its Analogues.

Nepetaefolin F (), an abietane diterpenoid, showed significant inhibitory activity against human cancer cells with an IC value of 6.3 μM. The syntheses of nepetaefolin F and its analogues are presented herein.

Analysis of selected sperm samples by a computer-assisted system with high frame rate: A prospective study.

Background And Aims: Due to the rapid motility of the selected sperm, sperm parameters cannot be accurately determined by the manual method. So, the application of a computer-assisted sperm analysis system with a high frame rate (HFR-CASA, 85 Hz) in sperm selection is investigated.

Methods: A total of 177 semen samples were collected for sperm selection with density gradient centrifugation.

Atractylodes Processing Products Protect against Gastric Ulcers in Rats by Influencing the NF-κB-MMP-9/TIMP-1 Regulatory Mechanism and Intestinal Flora.

Atractylodes macrocephala Koidz. (AM) is a Chinese herbal medicine that is widely used for treating gastrointestinal diseases. However, little research has focused on it as a single medicine for treating gastric ulcers.

What is the appropriate genetic testing criteria for breast cancer in the Chinese population?-Analysis of genetic and clinical features from a single cancer center database.

Background: Genetic testing plays an important role in guiding screening, diagnosis, and precision treatment of breast cancer (BC). However, the appropriate genetic testing criteria remain controversial. The current study aims to facilitate the development of suitable strategies by analyzing the germline mutational profiles and clinicopathological features of large-scale Chinese BC patients.

The prognostic value and immune microenvironment association of AR in HER2+ nonmetastatic breast cancer.

This study aimed to investigate the prognostic value of AR in HER2+ nonmetastatic breast invasive ductal carcinoma (IDC) and its relationship with the immune microenvironment. HER2+ nonmetastatic breast IDC patients diagnosed by pathology who underwent surgery at Sun Yat-sen University Cancer Center from 2016 to 2017 were included. AR+ and AR- breast IDC samples were matched 1:1 in age, T stage, and N stage for immune infiltration analysis.

Theoretical investigation of Aryl/Alkyl halide reduction with hydrated electrons from energy and AIMD aspects.

Context: In this study, the reactions of hydrated electron (e(aq)) with alkyl and aryl halides were simulated with an ab initial molecular dynamics (AIMD) method to reveal the underlying mechanism. An original protocol was developed for preparing the proper initial wavefunction guess of AIMD, in which a single electron was curled in a tetrahedral cavity of four water molecules. Our results show that the stability of e(aq) increases with the hydrogen bond grid integrity.

Distributed dynamic strain measurement with a direct detection scheme by using a three-step-phase-shifted double pulse in a UWFBG array.

We demonstrate a stable homodyne phase demodulation method with a double pulse based on an ultra-weak fiber Bragg grating (UWFBG) array. The technique divides one of the probe pulses into three sections and introduces successive 2π/3 phase differences into each section. By using a simple direct detection scheme, it can achieve distributed and quantitative vibration measurement along the UWFBG array.

The Effect of Ti Particles Addition on the Microstructure and Mechanical Behavior of Mg AZ31/Al 6082 Composite Sheets.

In this study, Ti particles reinforced Mg AZ31/Al 6082 composite sheets were successfully prepared by hot rolling, with the aim of revealing the effect of Ti particles addition on the mechanical behavior and microstructure of Mg AZ31/Al 6082 composite sheets. The results showed that Ti particles were uniformly distributed at the interface of the Mg/Al-Ti composite sheets, which could greatly reduce the amount of Mg-Al intermetallic compounds during annealing treatment. Compared to the Mg/Al sheet, the tensile strength and elongation of the Mg/Al-Ti sheet could be improved simultaneously after the annealing treatment.

Circulating IGFBP-3 and Interleukin 6 as Predictors of Osteoporosis in Postmenopausal Women: A Cross-Sectional Study.

Objective: To explore the relationship between circulating IGFBP-3, IL-6, and bone mineral density and the potential diagnostic role of circulating IGFBP-3 and IL-6 in postmenopausal women with osteoporosis.

Methods: Eighty-five postmenopausal women at Soochow University's First Affiliated Hospital, Osteoporosis and Menopause Clinics, were recruited. Forty-five of 85 women were diagnosed with osteoporosis.

Myocardial Inflammation on FDG PET/MRI and Clinical Outcomes in Symptomatic and Asymptomatic Participants after COVID-19 Vaccination.

Purpose: To evaluate potential cardiac sequelae of COVID-19 vaccination at 2-month follow-up and relate cardiac symptoms to myocardial tissue changes on fluorodeoxyglucose (FDG) PET/MRI, blood biomarkers, health-related quality of life, and adverse outcomes.

Materials And Methods: In this prospective study (ClinicalTrials.gov: NCT04967807), a convenience sample of individuals aged ≥17 years were enrolled after COVID-19 vaccination and were categorized as symptomatic myocarditis (new cardiac symptoms within 14 days of vaccination and met diagnostic criteria for acute myocarditis), symptomatic no myocarditis (new cardiac symptoms but did not meet criteria for myocarditis), and asymptomatic (no new cardiac symptoms).

Twelve-Month Outcomes of Simultaneous Translabyrinthine Resection and Cochlear Implantation.

Objective: Audiometric outcomes at 12 months following simultaneous translabyrinthine (TL) resection of vestibular schwannoma (VS) and cochlear implantation (CI).

Study Design: Prospective cohort study.

Setting: Tertiary referral center.

Effects of an evidence-based model for cochlear implant aftercare delivery on clinical efficiency and patient outcomes.

Objectives: To assess an evidence-based model (EBM) approach to cochlear implant (CI) aftercare that includes a modified, reduced treatment schedule for newly-implanted adult CI recipients consisting of four appointments (initial activation, 1-, 3- and 6- months postactivation) in the first year post-surgery.

Method: This prospective multicenter proof-of-concept study was conducted across three clinics in the United States by five experienced CI clinicians. Seventeen newly-implanted adult patients with postlingual hearing loss enrolled in the study.

Construction and validation of a macrophage polarization-related prognostic index to predict the overall survival in patients with early-stage triple-negative breast cancer.

Background: Triple-negative breast cancer (TNBC) is a highly heterogeneous disease and the current prognostic system cannot meet the clinical need. Interactions between immune responsiveness and tumor cells plays a key role in the progression of TNBC and macrophages are vital component of immune cells. A prognostic model based on macrophages may have great accuracy and clinical utility.