Publications by authors named "Hong Qu Yan"
Article Synopsis
- Tyrosine hydroxylase (TH) is crucial for dopamine production in neurons, and there's emerging evidence that traumatic brain injury (TBI) disrupts dopamine neurotransmission.
- Researchers studied the effects of controlled cortical impact (CCI) injury on TH levels in rats at different recovery times (1, 7, and 28 days).
- Results showed that TH protein levels increased bilaterally in the nigrostriatal system of injured rats at 28 days, suggesting a compensatory response in dopaminergic neurons to enhance dopamine synthesis after TBI.
Disturbances in dopamine neurotransmission contribute to frontal lobe dysfunction after traumatic brain injury. The changes in dopamine neurotransmission may be mediated by alterations in the dopamine transporter, which plays a key role in maintaining dopamine homeostasis. To determine whether the dopamine transporter system is altered after traumatic brain injury, dopamine transporter protein was examined bilaterally in the rat frontal cortex by Western blot at 1, 7, and 28 days after controlled cortical impact or sham injury ( = 6/group).
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