Publications by authors named "Hong Min"

GeTe-based films have attracted tremendous attention from the thermoelectric community owing to their excellent thermoelectric performance. It is vital to reduce the hole density and maintain a high carrier mobility for GeTe films; however, this remains a significant challenge. To overcome this drawback, we succeeded in fabricating high-crystalline quality GeTe-based films and remarkably improve their electrical properties using molecular beam epitaxy under a low substrate temperature and optimized Te/GeTe flux ratios.

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In the context of Industry 4.0, improving energy efficiency in smart factories has emerged as a key priority to drive sustainable industrial growth. However, identifying optimal energy-saving solutions is challenging due to the inherent uncertainty and complexity in decision-making.

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Unlabelled: , a wheat U-box E3 ligase gene, was isolated and characterized for its role in drought stress tolerance. The gene encodes a 531 amino acid protein with a U-box domain at the N-terminal and a WD40 domain at the C-terminal. Subcellular localization studies using TaPRP19-GFP fusion in confirmed predominant nucleus localization.

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The healthcare industry, aided by technology, leverages the Internet of Things (IoT) paradigm to offer patient/user-related services that are ubiquitous and personalized. The authorized repository stores ubiquitous data for which access-level securities are granted. These security measures ensure that only authorized entities can access patient/user health information, preventing unauthorized entries and data downloads.

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This study aimed to investigate the therapeutic effect of human nasal turbinate-derived stem cells (hNTSCs) on mice with rheumatoid arthritis (RA) and identify hNTSC gene signatures with therapeutic effects on RA. hNTSCs were obtained from 20 healthy controls (HCs) who had undergone nasal turbinate surgery. Collagen-induced arthritis (CIA) mice were used to investigate the therapeutic effects of hNTSCs.

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Spin-orbit torque (SOT) magnetic memory technology has garnered significant attention due to its ability to enable field-free switching of magnets with strong perpendicular magnetic anisotropy (PMA). However, concerns regarding power consumption of SOT-memory are persisting. Here, this work proposes a method to construct magnetic tunnel junction (MTJ) by transferring chemically vapor-deposited two-dimensional (2D) CrTe/WS van der Waals (vdW) heterostructures onto 2D FeGeTe (FGT) magnet.

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Heat stress significantly impacts plant growth and productivity by causing protein misfolding, oxidative damage, and disruptions in cellular homeostasis. This stress is particularly critical during flowering and grain-filling stages, where even brief exposure to high temperatures can result in severe yield losses. Plants have evolved complex molecular mechanisms to mitigate heat stress, including the activation of heat shock proteins and the ubiquitin-proteasome system to maintain protein quality and cellular function.

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Background: Venadaparib, a novel poly (ADP-ribose) polymerase (PARP) inhibitor, has demonstrated high PARP-1/2 selectivity over other PARP family members and exhibited strong PARP-trapping activity, effectively inhibiting tumor growth in homologous recombination deficient (HRD) cancer in vitro and in vivo.

Methods: This phase 1, dose-finding study evaluated the safety, tolerability, pharmacokinetics, pharmacodynamics and anticancer efficacy of venadaparib as monotherapy in patients with advanced solid tumors that progressed after standard-of-care therapy. The study employed a conventional 3+3 design, with doses ranging from 2 mg/d to 240 mg/d.

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Wheat, a staple crop cultivated for over 8000 years, sustains more than 2.5 billion people globally, as a major source of carbohydrate, protein, fiber, and essential nutrients. Colored wheat, enriched with dietary fiber and antioxidants, offers valuable genetic resources for developing functional wheat varieties.

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This study proposes a classification system for predicting chronic obstructive pulmonary disease (COPD) patients and non-patients based on image and text data. This study measured the respiratory volume based on thermal images, stored the respiratory data, and derived features related to respiratory patterns, including the total respiratory volume, average distance between expirations, average distance between inspirations, and total respiratory rate. The data for each feature were stored in text format.

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Background: Healthcare-associated infections (HAI) are infections acquired by patients during treatment in various healthcare institutions. These infections significantly increase morbidity, mortality, and healthcare costs. Enhancing HAI education for nurses can improve patient safety and medical quality.

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Purpose: The TRIUMPH trial was a biomarker-driven umbrella trial for patients with recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC). This analysis focuses on the PIK3CAɑ inhibitor alpelisib (arm 1) in patients with phosphoinositide 3-kinase (PI3K) pathway alterations.

Materials And Methods: Patients with PI3K pathway altered tumors were enrolled in the alpelisib arm of the TRIUMPH study.

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Background: SYNGAP1 encodes a Ras/Rap GTPase-activating protein that is predominantly expressed in the brain with the functional roles in regulating synaptic plasticity, spine morphogenesis, and cognition function. Pathogenic variants in SYNGAP1 have been associated with a spectrum of neurodevelopmental disorders characterized by developmental delays, intellectual disabilities, epilepsy, hypotonia, and the features of autism spectrum disorder. The aim of this study was to identify a novel SYNGAP1 gene variant linked to neurodevelopmental disorders and to evaluate the pathogenicity of the detected variant.

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Uncommon epidermal growth factor receptor (EGFR) mutations in non-small cell lung cancer (NSCLC) pose therapeutic challenge due to limited response to EGFR tyrosine kinase inhibitors (TKIs). This study presents preclinical evidence and mechanistic insights into the combination of lazertinib, a third-generation EGFR-TKI; and amivantamab, an EGFR-MET bispecific antibody, for treating NSCLC with uncommon EGFR mutations. The lazertinib-amivantamab combination demonstrates significant antitumor activity in patient-derived models with uncommon EGFR mutations either before treatment or after progressing on EGFR-TKIs.

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This study investigates the antimalarial potential of extracts and compounds from various plants used in traditional Korean medicine, in response to the increasing resistance of to standard treatments such as chloroquine and artemisinin. The antimalarial activity screening was conducted on 151 extracts, identifying the top seven candidates, including (50% ethanol and 100% methanol extract), , (hot water and 50% ethanol extract), , and . Among these, was identified as the top priority for further analysis due to its high antimalarial activity and high yield of bioactive compounds.

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Improving energy efficiency is crucial for smart factories that want to meet sustainability goals and operational excellence. This study introduces a novel decision-making framework to optimize energy efficiency in smart manufacturing environments, integrating Intuitionistic Fuzzy Sets (IFS) with Multi-Criteria Decision-Making (MCDM) techniques. The proposed approach addresses key challenges, including reducing carbon footprints, managing operating costs, and adhering to stringent environmental standards.

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Radiofrequency ablation (RFA) is a minimally invasive treatment modality used as an alternative to surgery in patients with benign thyroid nodules, recurrent thyroid cancers (RTCs), and primary thyroid microcarcinomas. The Korean Society of Thyroid Radiology (KSThR) initially developed recommendations for the optimal use of RFA for thyroid tumors in 2009 and revised them in 2012 and 2017. As new meaningful evidence has accumulated since 2017 and in response to a growing global interest in the use of RFA for treating malignant thyroid lesions, the task force committee members of the KSThR decided to update the guidelines on the use of RFA for the management of RTCs based on a comprehensive analysis of current literature and expert consensus.

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Utilizing information from multiple sources is a preferred and more precise method for medical experts to confirm a diagnosis. Each source provides critical information about the disease that might otherwise be absent in other modalities. Combining information from various medical sources boosts confidence in the diagnosis process, enabling the creation of an effective treatment plan for the patient.

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Article Synopsis
  • Primary cutaneous mucinous carcinoma (PCMC) is a rare skin cancer that primarily develops from eccrine sweat glands, commonly appearing on the head and neck of older adults and often exhibiting slow growth.
  • Although it rarely spreads to other parts of the body, PCMC has a high rate of recurrence, making early and accurate diagnosis through biopsy crucial.
  • A case study of a 77-year-old man highlighted the challenges in diagnosing PCMC, leading to surgical removal and further treatment, ultimately resulting in no signs of recurrence one year later.
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Erastin, as an effective ferroptosis inducer, has received extensive attention in anti-tumor research. To develop an oral nanocarrier for high efficient loading hydrophobic erastin, here we prepared a fluoro-liposome (FA-3 F-LS) by the self-assembly of the folic acid modified fluorinated amphiphiles-FA-3 F conjugates. The hydrophobic component of three perfluorooctyl chains endows the FA-3 F-LSs with high stability to resist the harsh gastrointestinal tract condition.

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Article Synopsis
  • The study evaluates the effectiveness of slope parameter images (SPI) from dual-phase dual-energy CT enterography (DE-CTE) for diagnosing and assessing Crohn's disease (CD) activity.
  • Researchers analyzed data from 76 CD patients and 53 controls, finding significant differences in dual-phase SP and HU values between groups, indicating higher values in affected individuals.
  • The findings suggest that the AP SP of mesenteric fat shows the highest diagnostic potential for CD, emphasizing the usefulness of SPI in both diagnosis and assessing inflammation levels.
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Article Synopsis
  • AgSbTe is a promising p-type thermoelectric material that has seen improvements focused on reducing lattice thermal conductivity, but its low power factor limits device performance.
  • Recent research shows that doping AgSbTe with Sn creates a new impurity band, enhancing electrical properties and achieving a record-high power factor of 27 μWcmK and a peak thermoelectric figure of merit zT of 2.5 at 673 K.
  • The improved performance is due to increased hole concentration and reduced bipolar conductivity, resulting in an efficient thermoelectric device with energy conversion efficiencies of 12.1% and a power density of 1.13 Wcm.
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Introduction: Treatment with adjuvant osimertinib for three years is the standard-of-care for resected stage IB to IIIA NSCLC harboring EGFR mutations. The role of neoadjuvant osimertinib in the perioperative setting is yet to be elucidated in the NeoADAURA study (NCT04351555).

Methods: This is a single-center, pilot study of patients with clinical stage IA to IIIA NSCLC (American Joint Committee on Cancer eighth edition) harboring an activating EGFR mutation (Exon 19 deletion, L858R) (NCT04816838).

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Immune checkpoint blockade (ICB) has become a standard anti-cancer treatment, offering durable clinical benefits. However, the limited response rate of ICB necessitates biomarkers to predict and modulate the efficacy of the therapy. The gut microbiome's influence on ICB efficacy is of particular interest due to its modifiability through various interventions.

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