Three new sesquiterpenoid alkaloids from the roots of and its cytotoxicity.

Three new sesquiterpenoid alkaloids, cangorin K (), dimacroregelines C () and D (), as well as two known sesquiterpenoids (-), were isolated from the roots of The structures of new compounds were characterised by extensive 1D and 2D NMR spectroscopic analyses, as well as HRESIMS data, and the known compounds were established by 1 D NMR spectra referring to the literatures. Cytotoxicity evaluation of these compounds against two human tumour lines (SMMC7721, LN229) was investigated by CCK-8 assay and displayed that compounds - showed potent cytotoxicity against SMMC7721 cell with IC value in the range of 0.26-9.

Melongenaterpenes A-L, Vetispirane-Type Sesquiterpenoids from the Roots of .

Melongenaterpenes A-L (-), 12 new sesquiterpenoids with rare spiro[4.5]decane skeletons, were isolated from the roots of . Their 2D structures and relative configurations were determined based on NMR and HRESIMS data.

Proteomics Research on the Protective Effect of Mangiferin on H9C2 Cell Injury Induced by HO.

Cardiovascular disease is one of the leading causes of morbidity and mortality worldwide. Mangiferin is a natural glucosylxanthone with antioxidant and anti-inflammatory properties, which has been confirmed to protect cardiac cells from myocardial infarction and myocardial ischemia reperfusion injury (MIRI); however, the underlying mechanism is still unclear. As oxidative stress is a major pathogenesis of MIRI, an H9C2 cell injury induced by hydrogen peroxide (HO) was established to simulate MIRI in vitro.