Quantifying and interpreting biologically meaningful spatial signatures within tumor microenvironments.

The tumor microenvironment (TME) plays a crucial role in orchestrating tumor cell behavior and cancer progression. Recent advances in spatial profiling technologies have uncovered novel spatial signatures, including univariate distribution patterns, bivariate spatial relationships, and higher-order structures. These signatures have the potential to revolutionize tumor mechanism and treatment.

Effects of non-pharmacological interventions on sexual health in patients with breast cancer: A network meta-analysis.

Objective: This review systematically identifies and synthesizes evidence to examine the impact of non-pharmacological interventions on the sexual health of patients with breast cancer through a meta-analysis approach.

Methods: From establishment to December 2, 2024, eight electronic databases including PubMed, Embase, Web of Science, Cochrane, CNKI, VIP, Wanfang and Biomedical Literature Service System were searched. The inclusion criteria comprised randomized controlled trials (RCTs) of non-drug interventions, controlled clinical trials and quasi-experimental studies.

N-terminal domain of CTRP9 promotes cardiac fibroblast activation in myocardial infarction via Rap1/Mek/Erk pathway.

Background: In developed nations, myocardial infarction (MI) is one of the main causes of morbidity and mortality, resulting in a significant economic burden and becoming a global public health problem. C1q/tumor necrosis factor-related protein 9 (CTRP9) is a secreted protein comprising a variable domain, a collagenous region, and a C-terminal trimerizing globular C1q (gC1q) domain. In vivo, the full-length CTRP9 (fCTRP9) can be cleaved into the globular domain of CTRP9 (gCTRP9).

LILRB3 genetic variation is associated with kidney transplant failure in African American recipients.

African American (AA) kidney transplant recipients exhibit a higher rate of graft loss compared with other racial and ethnic populations, highlighting the need to identify causative factors. Here, in the Genomics of Chronic Allograft Rejection cohort, pretransplant blood RNA sequencing revealed a cluster of four consecutive missense single-nucelotide polymorphisms (SNPs), within the leukocyte immunoglobulin-like receptor B3 (LILRB3) gene, strongly associated with death-censored graft loss. This SNP cluster (named LILRB3-4SNPs) encodes missense mutations at amino acids 617-618 proximal to a SHP1/2 phosphatase-binding immunoreceptor tyrosine-based inhibitory motif.

Decreased gut microbiome-derived indole-3-propionic acid mediates the exacerbation of myocardial ischemia/reperfusion injury following depression via the brain-gut-heart axis.

Despite the increasing recognition of the interplay between depression and cardiovascular disease (CVD), the precise mechanisms by which depression contributes to the pathogenesis of cardiovascular disease remain inadequately understood. The involvement of gut microbiota and their metabolites to health and disease susceptibility has been gaining increasing attention. In this study, it was found that depression exacerbated cardiac injury, impaired cardiac function (EF%: P < 0.

Dietary management in the first stage of labor: A scoping review.

Aims: The aims herein are to describe the principal components of dietary management during the first stage of labor and to assess the outcome of childbirth.

Design: A scoping review.

Methods: We conducted a systematic search of eight databases from database establishment until June 30, 2024.

ITGA8 deficiency in hepatic stellate cells attenuates CCl-Induced liver fibrosis via suppression of COL11A1.

Background And Objective: Liver fibrosis is a pathological process driven by chronic liver injury, characterized by excessive extracellular matrix (ECM) deposition due to hepatic stellate cell (HSC) activation. Integrins are critical regulators of ECM remodeling and HSC activation, yet the role of integrin α8(ITGA8) in liver fibrosis remains unclear. This study aims to investigate the function and underlying mechanisms of HSC-derived ITGA8 in liver fibrosis and evaluate the therapeutic potential of ITGA8-targeted intervention.

Individualized Nutritional Support Improves Cardiac Function and Nutritional Status of Elderly Heart Failure Patients.

Background    The quality of life of the patient is diminished by chronic heart failure (CHF), which also costs the healthcare system. This study examined the benefits of individualized nutritional support provided by a specialized nursing team on the nutritional status and cardiac function of elderly patients with CHF.Material and methods    This study included 102 elderly, hospitalized CHF patients.

Rutin resists Aspergillus fumigatus keratitis by activating Nrf2/HO-1 pathway, inhibiting Dectin-1/p-Syk pathway and affecting fungal structures.

Fungal keratitis (FK) is a severe vision-threatening eye disease. The fungal invasiveness and excessive inflammatory response contribute to corneal tissue damage. Rutin (RT) possesses anti-inflammatory, antimicrobial, antioxidant, and improved wound-healing characteristics.

A nomogram prediction model for embryo implantation outcomes based on the cervical microbiota of the infertile patients during IVF-FET.

The microbiota of the female genital tract is crucial for reproductive health. This study aims to investigate the impact of the lower genital tract microbiota on fertilization and frozen embryo transfer (IVF-FET) outcomes. This study included 131 women aged 20-35 years who underwent their first or second IVF-FET cycle with no obvious unfavorable factors for implantation.

The RNA-binding protein LARP6 regulates the alternative splicing of related genes in MDA-MB-231 cells.

Triple-negative breast cancer (TNBC) has the highest mortality rate of all breast cancer subtypes and currently lacks effective targeted therapies. LARP6 is an RNA-binding protein associated with cancer promotion, but its mechanism of action in TNBC remains unclear. We conducted RNA sequencing (RNA-seq) and improved RNA immunoprecipitation and sequencing (iRIP-seq) to identify the differentially expressed genes (DEGs) and alternative splice sites bound and regulated by LARP6 in MDA-MB-231 cells.

Recent advances in understanding the mechanisms of plant cadmium accumulation as affected by grafting in vegetable production.

Heavy metals in agricultural soils pose a major threat to food safety and human health. Among all heavy metals, cadmium (Cd) is the most problematic with contamination rates of 7% in arable land and 5.3% in facility vegetable growing soils in China.

Atmospheric sulfate aerosol formation enhanced by interfacial anions.

Heterogeneous oxidation of SO by NO on aerosols has recently been found to be one of the major formation pathways of sulfate in the polluted troposphere, but the chemical mechanisms and kinetics remain uncertain. By combining lab experiments, theoretical chemistry calculations, and field measurements, here we show that the SO oxidation by NO is critically dependent on anions at the air-aerosol aqueous interface. The reaction rate of NO with (1.

Poor bony density can independently trigger higher incidence of adjacent vertebral fracture after percutaneous vertebralplasty: a mono-center retrospective study.

Objective: Symptomatic adjacent vertebral fractures (AVF) poses a challenge to patient prognosis in osteoporotic vertebral compressive fractures (OVCF) treated by percutaneous vertebralplasty (PVP). This study aimed to identify potential risk factors for AVF, thereby offering theoretical insights for refining patient management strategies and surgical protocols.

Methods: Clinical data of PVP patients treated between March 2018 and May 2020 were retrospectively analyzed, with an average follow-up period of 30 months.

Spatial interpolation and spatiotemporal scanning analysis of human brucellosis in mainland China from 2012 to 2018.

Despite the considerable efforts made to address the issue of brucellosis worldwide, its prevalence in dairy products continues to be difficult to estimate and represents a significant public health concern globally. The aim of the present study was to gain a better understanding of the epidemiology of this disease in mainland China. We set out to investigate the annual spatial distribution and potential hotspots of the disease.

N-glycosylation of GSTO1 promotes cervical cancer migration and invasion through JAK/STAT3 pathway activation.

Protein glycosylation is strongly associated with tumor progression. Glutathione S-transferase omega 1 (GSTO1) is a member of the glutathione S-transferase family. The significance of GSTO1 N-glycosylation in the progression of cervical cancer (CC) has remained elusive.

Oncofertility Barriers in Nurses Caring for Women with Breast Cancer.

Despite the importance of oncofertility care in supporting women coping with fertility challenges after breast cancer, the practice of oncofertility care among nurses remains suboptimal. There is an urgent need to investigate oncofertility barriers faced by nurses caring for women with breast cancer. A cross-sectional online study was conducted among registered nurses caring for women with breast cancer.

vB_Ent31 bacteriophage may combat Enterobacter cloacae infections with macrophage modulating activity.

Multidrug-resistant organisms (MDRO), including MDR Enterobacter cloacae, may emerge due to the extensive usage of antibiotics and threaten the lives of millions of people around the world. Developing new antibiotic-free strategies to combat E. cloacae infections and curb the spread of drug-resistant genes is crucial.

Protective role of mitophagy on microglia-mediated neuroinflammatory injury through mtDNA-STING signaling in manganese-induced parkinsonism.

Manganese (Mn), the third most abundant transition metal in the earth's crust, has widespread applications in the emerging field of organometallic catalysis and traditional industries. Excessive Mn exposure causes neurological syndrome resembling Parkinson's disease (PD). The pathogenesis of PD is thought to involve microglia-mediated neuroinflammatory injury, with mitochondrial dysfunction playing a role in aberrant microglial activation.

The Trim32-DPEP2 axis is an inflammatory switch in macrophages during intestinal inflammation.

The mechanisms via which inflammatory macrophages mediate intestinal inflammation are not completely understood. Herein, using merged analysis of RNA sequencing and mass spectrometry-based quantitative proteomics, we detected differences between proteomic and transcriptomic data in activated macrophages. Dipeptidase-2 (DPEP2), a member of the DPEP family, was highly expressed and then downregulated sharply at the protein level but not at the mRNA level in macrophages in response to inflammatory stimulation.

Cardiovascular disease risk in cancer survivors: a population-based cohort study from the UK Biobank, and meta-analysis of cohort studies.

Introduction: In addition to the well-recognised cardiotoxicity of cancer treatment, possible aetiological links between cancer diagnosis and cardiovascular disease (CVD) have gained growing research interests. We aimed to estimate the CVD burden among cancer survivors and illustrate population-level associations between these two conditions.

Methods: We first conducted a prospective cohort study in the UK Biobank and a meta-analysis of previous population-based cohorts.

Metabolic reprogramming of peritoneal mesothelial cells in peritoneal dialysis-associated fibrosis: therapeutic targets and strategies.

Peritoneal dialysis (PD) is considered a life-saving treatment for end-stage renal disease. However, prolonged PD use can lead to the development of peritoneal fibrosis (PF), diminishing its efficacy. Peritoneal mesothelial cells (PMCs) are key initiators of PF when they become damaged.

Thiazolium-Linked Crystalline Porous Covalent Organic Frameworks for Mixed Electronic-Ionic Transport.

Developing efficiently mixed electronic-ionic (MEI) conductive microcosmic pathways within a single functional material is essential yet challenging for electronic devices. Covalent organic frameworks (COFs) feature pre-designed functionalities and uniform pores, making them highly desirable platforms for transporting electrons and ions. However, for MEI conductive COFs, achieving high crystallinity when incorporating high-density ionic groups within the extensively π-electron delocalized skeletons remain a challenge due to intermolecular interactions.

Neutrophil-secreted CHI3L1 exacerbates cardiac dysfunction and inflammation after myocardial infarction.

Myocardial infarction (MI) triggers acute inflammation, marked by neutrophil infiltration. Although neutrophils are central to this response, the exact role of various neutrophil-derived factors is not fully understood. Clinical studies have linked one such enigmatic factor, chitinase-3 like-1, to MI outcomes.

The Association Between Periodontitis and the Prevalence and Prognosis of Metabolic Syndrome.

Objective: Periodontitis and metabolic syndrome (MetS) are both linked to inflammation, but their association remains unclear. This study aimed to explore the association between periodontitis and MetS prevalence and evaluate its impact on the prognosis of all-cause and cardiovascular mortality in MetS.

Methods: Data were obtained from the National Health and Nutrition Examination Survey (NHANES) database.