Publications by authors named "Hong Jun Fang"

Article Synopsis
  • Developmental and epileptic encephalopathy (DEE) shows genetic diversity, and this study focused on three cases linked to biallelic variants in the SZT2 gene, known as DEE18.
  • Analysis included trio-whole exome sequencing and simulations, revealing that the identified variants could structurally affect the SZT2 protein, potentially leading to increased mTORC1 signaling and seizures.
  • The research highlights the correlation between the severity of developmental disorders and the type of SZT2 variants, underscoring the importance of genetic testing for better diagnosis and individualized treatment options for DEE patients.
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Objective: Resection of high-grade glioma with sodium fluorescein can improve the resection rate of the glioma and improve survival. However, it is unclear whether the yellow fluorescence boundary of the high-grade glioma is consistent with the actual boundary of the tumor. This study explores the yellow fluorescence boundary and the actual tumor boundary in high-grade glioma surgery.

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ABSTACT: The effects of melittin on growth and bacteriostasis of four pathogens were extensively investigated using scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The results indicated that the melittin had a marked bacteriostatic effect on the four pathogenic bacteria. Among these, E.

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Objective: To evaluate the impact of health education intervention on promoting rural residents to join new rural cooperative medical system (NCMS) and their intention of joining NCMS based on Health Belief Model in project areas in Henan and Jilin Provinces.

Methods: Quasi-experiment study was used to evaluate intervention impact. Following the evidence-based approach, according to needs assessment, a half-year health education intervention was implemented among farmers in the experimental counties in Henan and Jilin Provinces respectively.

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The condition for high-yield suspension cell line and the precursors of volatile oil synthesis of Curcuma zedoaria (Berg.) Rosc were studied. The results showed that the light yellow particle callus was suitable for establishment of the high-yield suspension cell line.

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Agrobacterium-mediated transformation in chrysanthemum was studied to prevent the insect pest of aphid (Mizus persicae). The gna gene was successfully transferred into chrysanthemum by leaf dish, and 93 transgenic clones were obtained. The highest transformation frequency 11.

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Mutant strain WYBS2001 of B. subtilis with strong anti-pathogenic activity was obtained by mutagenic ultraviolet rays. The gene fragment of Human Epidermal Growth Factor(hegf) of 175 bp was synthesized by PCR and the restriction sites Pst I and Hind III, original code and the signal sequence CTTAGA of secreting vector pUS186 were induced in the fragment.

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