Development of a novel N14-substituted antitumor evodiamine derivative with inhibiting heat shock protein 70 in non-small cell lung cancer.

Notwithstanding the latest advancements in anticancer therapy, non-small cell lung cancer (NSCLC) remains a prominent contributor to cancer-associated mortality worldwide. Therefore, effective anti-cancer agents are required for the treatment of NSCLC. We previously demonstrated that the natural alkaloid evodiamine efficiently suppressed lung cancer cells and lung cancer stem-like cell populations by suppressing heat shock protein 70 (Hsp70).

HIF-1α stabilization inhibits Japanese encephalitis virus propagation and neurotoxicity via autophagy pathways.

Japanese encephalitis (JE) is a widespread flavivirus that induces brain inflammation and affects the central nervous system (CNS). Deferoxamine, an iron chelator, has shown promising results in stabilizing HIF-1α, a protein that improves hypoxic conditions, offers protective effects against neurological, and neurodegenerative diseases. This study aimed to assess the impact of HIF-1α stabilization during JEV infection using SH-SY5Y neuroblastoma cell lines as a model.

Flexomagnetoelectric Effect in Sr_{2}IrO_{4} Thin Films.

Symmetry engineering is explicitly effective to manipulate and even create phases and orderings in strongly correlated materials. Flexural stress is universally practical to break the space-inversion or time-reversal symmetry. Here, by introducing strain gradient in a centrosymmetric antiferromagnet Sr_{2}IrO_{4}, the space-inversion symmetry is broken accompanying a nonequivalent O p-Ir d orbital hybridization along the z axis.

Multimodal human computer interaction of wheelchairs supporting lower limb active rehabilitation.

Currently, an important challenge in stroke rehabilitation is how to effectively restore motor functions of lower limbs. This paper presents multimodal human computer interaction (HCI) of wheelchairs supporting lower limb active rehabilitation. First, multimodal HCI incorporating motor imagery electroencephalography (EEG), electromyography (EMG) and speech is designed.

Peripheral cranio-spinal nerve communication for trapezius muscle control using axonal profiling through immunostaining.

Accessory nerve (CNXI) has been known to be the primary conduit for motor control of the trapezius, while the supplementary cervical nerves (C3 and C4) are responsible for processing sensory information from muscle. However, the lack of substantial direct evidence has led to these conclusions being regarded as mere speculation. This study used immunostaining (using antibodies against neurofilament 200 for all axons, choline acetyltransferase for cholinergic axons, tyrosine hydroxylase for sympathetic axons, and alpha 3 sodium potassium ATPase for proprioceptive afferent axons) of human samples to verify the functional contributions of nerves.

Viscoelastic and antimicrobial dental care bioplastic with recyclable life cycle.

Medical plastic-appliance-based healthcare services, especially in dentistry, generate tremendous amounts of plastic waste. Given the physiological features of our mouth, it is desirable to substitute dental care plastics with viscoelastic and antimicrobial bioplastics. Herein, we develop a medical-grade and sustainable bioplastic that is viscoelastic enough to align the tooth positions, resists microbial contamination, and exhibits recyclable life cycles.

Prediabetes persistence or remission and subsequent risk of gallbladder cancer: A nationwide cohort study.

Background & Aims: Hyperglycemia is associated with an increased risk of gallbladder cancer (GBC), potentially by inhibiting gallbladder motility and inducing prolonged cholestasis. Although intermediate hyperglycemia (or prediabetes) is highly reversible, evidence is lacking about whether prediabetes persistence or remission is associated with an altered GBC risk.

Methods: This nationwide cohort study included 6058,662 adults without diabetes or cancer who underwent national health examinations twice in 2-year intervals between 2009 (S1) and 2011 (S2) and were followed-up until 2018.

Physical Reservoir Computing Using Tellurium-Based Gate-Tunable Artificial Photonic Synapses.

We report tellurium (Te) thin-film-based artificial photonic synapses and their application to physical reservoir computing (PRC). The Te-based artificial photonic synapses were fabricated by using sputtered Te thin films and spray-coated MXene (TiC) electrodes. A thorough investigation of the field-dependent persistent photoconductivity (PPC) of the Te channel revealed that the relaxation speed of the transient photocurrent depended on the gate bias.

Rosmarinic acid promotes cartilage regeneration through Sox9 induction via NF-κB pathway inhibition in mouse osteoarthritis progression.

Background: The natural polyphenolic compound known as Rosmarinic acid (RosA) can be found in various plants. Although its potential health benefits have been extensively studied, its effect on osteoarthritis (OA) progression and cartilage regeneration function still needs to be fully elucidated in OA animal models. This study elucidated the effect of RosA on OA progression and cartilage regeneration.

Achieving High Stability and Capacity in Micron-Sized Conversion-Type Iron Fluoride Li-Metal Batteries.

Iron fluoride, a conversion-type cathode material with high energy density and low-cost iron, holds promise for Li-ion batteries but faces challenges in synthesis, conductivity, and cycling stability. This study addresses these issues by synthesizing micron-sized iron-fluoride using a simple solid-state synthesis. Despite a large particle size, a high capacity of 571 mAh g is achieved, which is attributed to the unique surface and internal pores within the iron-fluoride particles, which provided a large surface area.

Increased risk of genitourinary cancer in kidney transplant recipients: a large-scale national cohort study and its clinical implications.

Purpose: To investigate the risk of genitourinary (GU) cancer in kidney transplant recipients (KTRs) compared to that in the general population, focusing on potential risk factors and clinical implications.

Methods: Using a national cohort of approximately 360,000 individuals, including 31,542 KTRs, we conducted a retrospective analysis of the data from 2007 to 2018. Propensity score matching was used to compare KTRs with a healthy population, adjusting for age, sex, diabetes, hypertension, and hypercholesterolemia.

Durable mixed chimerism may permit subsequent immunosuppression-free intestinal transplantation-A proof-of-principle study.

Intestinal transplantation (ITx) is the definitive treatment for intestinal failure but has the highest rejection rate among solid organ transplants, requiring high doses of immunosuppressive medication, which is associated with high rates of infection, graft-versus-host disease, and malignancy. Transplant tolerance would overcome the need for long-term immunosuppression (ISP). Using nonmyeloablative conditioning, our laboratory has developed a novel swine model of hematopoietic stem cell transplantation (HSCT) that produces durable mixed chimerism (MC) and immune tolerance without toxicity.

A dynamic authorizable ciphertext image retrieval algorithm based on security neural network inference.

In this paper, we propose a dynamic authorizable ciphertext image retrieval scheme based on secure neural network inference that effectively enhances the security of image retrieval while preserving privacy. To ensure the privacy of the original image and enable feature extraction without decryption operations, we employ a secure neural network for feature extraction during the index construction stage of encrypted images. Additionally, we introduce a dynamic authenticatable ciphertext retrieval algorithm to enhance system flexibility and security by enabling users to quickly and flexibly retrieve authorized images.

Microbial and Transcriptomic Landscape Associated With Neutrophil Extracellular Traps in Perianal Fistulizing Crohn's Disease.

Background: Perianal fistulizing Crohn's disease (pfCD) poses significant healing challenges, closely associated with neutrophil extracellular traps (NETs). This study aimed to investigate the microbe-host interactions influencing NETs in pfCD.

Methods: From January 2019 to July 2022, patients with pfCD were screened at Ren Ji Hospital.

Meta-analysis of deep learning approaches for automated coronary artery calcium scoring: Performance and clinical utility AI in CAC scoring: A meta-analysis: AI in CAC scoring: A meta-analysis.

Introduction: Manual Coronary Artery Calcium (CAC) scoring, crucial for assessing coronary artery disease risk, is time-consuming and variable. Deep learning, particularly through Convolutional Neural Networks (CNNs), promises to automate and enhance the accuracy of CAC scoring, which this study investigates.

Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we conducted a comprehensive literature search across PubMed, Embase, Web of Science, and IEEE databases from their inception until November 1, 2023, and selected studies that employed deep learning for automated CAC scoring.

One-Dimensional Flexible Capacitive Sensor with Large Strain and High Stability for Human Motion Monitoring.

Flexible capacitive sensors have attracted the attention of researchers owing to their simple structure, ease of realization, and wearability. Currently, flexible capacitive sensors mainly have three-dimensional and two-dimensional structures, which are subject to several limitations in their applications. A low-cost, high-efficiency, and continuously processable process was used to wrap nylon DTY (PA) filaments on the surface of silver-coated nylon (SCN) core yarns and impregnate them with waterborne polyurethane (WPU) to obtain SCN/PA/WPU composite yarns, which were then utilized in the design of SCN/PA/WPU for the preparation of one-dimensionally structured flexible capacitive sensors.

MG4101, an allogeneic natural killer cell, in patients with relapsed or refractory acute myeloid leukemia: a pilot study.

We evaluated the safety and efficacy of allogeneic, ex-vivo expanded, NK cells, MG4101, in patients with refractory or relapsed AML. The relationship between immunological characteristics and clinical responses was analyzed. Between April 2018 and February 2020, 11 patients (male:female = 5:6) were treated with MG4101.

Real-world perioperative treatment patterns and burden of recurrent disease in patients with high-risk endometrial cancer: a SEER-Medicare study.

Objectives: To elucidate unmet needs in high-risk endometrial cancer (EC), this study described perioperative treatment patterns in Medicare beneficiaries with high-risk EC and quantified the impact of disease recurrence on clinical and economic outcomes among patients receiving adjuvant therapy.

Methods: Patients aged ≥66 years with high-risk EC (stage I/II EC of non-endometrioid histology or stage III/IVA EC of any histology) receiving hysterectomy with bilateral salpingo-oophorectomy from SEER-Medicare data (2007-2019) were identified; perioperative treatment patterns were described. Post-operative treatment patterns were described among patients receiving adjuvant therapy; overall survival (OS), all-cause and EC-related healthcare resource utilization and costs were evaluated from recurrence date (using a claims-based algorithm developed with clinical input) for recurrent patients and from a frequency-matched date for non-recurrent patients.

Synergistic effects of antimicrobial components of the human-derived composite amnion-chorion membrane on bacterial growth.

Introduction: The human-derived amnion-chorion membrane (ACM) has endogenous antimicrobial properties, which are important for preventing the colonization and survival of oral bacteria on exposed membranes. This project aimed to decipher the underlying mechanism by identifying the components of ACM that confer antibacterial properties. In addition, the antimicrobial efficacy of these identified components on oral bacteria was assessed.

Hoxc10-mediated 'positional memory' regulates cartilage formation subsequent to femoral heterotopic grafting.

The Hox gene plays a crucial role in the bone development, determining their structure and morphology. Limb bone grafts expressing Hox positive genes are commonly used for free transplantation to repair Hox negative mandibular critical bone defects. However, the specific role of original Hox genes in newly formed bone during the cross-layer bone grafting healing process remains unexplored.