The impact of family socioeconomic status on adolescent mental and physical health: the mediating role of parental involvement in youth sports.

Introduction: The physical and mental health of adolescents is a crucial cornerstone for social development. Therefore, this study aimed to examine whether family socioeconomic status made a difference in Chinese teenage mental and physical health and to disentangle the mediating role of parental involvement in youth sports in the process in which family socioeconomic status influenced adolescent health.

Methods: A quantitative analysis used a sample of approximately 11,000 adolescents from Chinese middle schools.

The genus : a fascinating resource for medicinal and botanical studies.

The genus , comprising a series of distinctive medicinal plants, has been utilized globally for its therapeutic properties over centuries. Modern pharmacological studies have demonstrated that secondary metabolites from species exhibit significant pharmacological activities, including anticancer, hemostatic, anti-inflammatory, antimicrobial, and other effects. Additionally, the unique morphological traits and large genome size of species have continuously captured the interest of botanists and horticulturalists.

Toosendanin-induced liver damage through irreparable DNA damage and autophagy flow blockade.

Objective: The fruit of Melia toosendan Sieb. et Zucc. (MT) is known for its efficacy in relieving pain and treating roundworms.

An intelligent network framework for driver distraction monitoring based on RES-SE-CNN.

As the quantity of motor vehicles and drivers experiences a continuous upsurge, the road driving environment has grown progressively more complex. This complexity has led to a concomitant increase in the probability of traffic accidents. Ample research has demonstrated that distracted driving constitutes a primary human - related factor precipitating these accidents.

Integrative spatial analysis reveals tumor heterogeneity and immune colony niche related to clinical outcomes in small cell lung cancer.

Recent advances have shed light on the molecular heterogeneity of small cell lung cancer (SCLC), yet the spatial organizations and cellular interactions in tumor immune microenvironment remain to be elucidated. Here, we employ co-detection by indexing (CODEX) and multi-omics profiling to delineate the spatial landscape for 165 SCLC patients, generating 267 high-dimensional images encompassing over 9.3 million cells.

Optimization of Microsatellite Multiplex PCRs for Triploidy Verification and Genetic Diversity Assessment in the Pacific Oyster, Crassostrea gigas.

The ploidy detection is crucial for the oyster industry. The objective of this study was to develop a method that verifies ploidy of the triploid Pacific oyster Crassostrea gigas by analyzing the diversity of triploid through microsatellite multiplex PCRs using fluorescent universal primers. We developed four information-rich multiplex PCR panels, comprising a total of 12 genomic microsatellites located in the genome of the C.

Administration of a Next-Generation Probiotic Nissle 1917-GLP-1 Alleviates Diabetes in Mice With Type 1 and Type 2 Diabetes.

Diabetes mellitus (DM) is a persistent and steadily progressing metabolic condition distinguished by unregulated high levels of blood glucose. GLP1 receptor agonists have recently gained recognition as first-line therapies in selected instances, as per the updated ADA guidelines, highlighting their efficacy not only in glycemic control but also in their broader health benefits. Nonetheless, the efficacy of GLP-1 is limited by its brief duration of action, rapid clearance from the body, and challenges associated with subcutaneous administration.

Human hair follicle-derived mesenchymal stem cells improve ovarian function in cyclophosphamide-induced POF mice.

Introduction: Mesenchymal stem cell (MSCs) of different tissue origins have become a new option for the treatment of premature ovarian failure (POF) as they can recovery the ovarian function. However, there were rarely researches about human hair follicle-derived mesenchymal stem cells (HF-MSCs) in POF.

Objectives: In this study, we compared the effects of HF-MSCs and human umbilical cord mesenchymal stem cells (HU-MSCs) on POF models to explore the underlying molecular mechanisms.

Association between Fish Consumption and Stroke Incidence Across Different Predicted Risk Populations: A Prospective Cohort Study from China.

Objective: The relationship between fish consumption and stroke is inconsistent, and it is uncertain whether this association varies across predicted stroke risks.

Methods: A cohort study comprising 95,800 participants from the Prediction for Atherosclerotic Cardiovascular Disease Risk in China project was conducted. A standardized questionnaire was used to collect data on fish consumption.

Cellulose stabilized palm oil emulsions as 3D printing inks: Controlled release of d-limonene.

Natural essential oils, such as d-limonene, are frequently used as flavoring agents and fragrances in the food industry. However, their susceptibility to volatilization and chemical degradation poses challenges for widespread application. In this study, cellulose nanocrystals (CNCs) and cellulose nanofibers (CNFs) were used to stabilize palm oils (POs) with different melting points to prepare Pickering emulsions (PEs) for the encapsulation of d-limonene.

Discovery of quorum sensing inhibitors against Pseudomonas aeruginosa from Aspergillus sp. NB12.

Twelve secondary metabolites, including two undescribed steroids, aspesterols A (1) and B (2) and three new triterpenoids, aspertrinoids A-C (5-7), were isolated from the endophytic fungus Aspergillus sp. NB12 obtained from Hypericum patulum. Structurally, aspertrinoids A-C (5-7) were 30-norlanostane triterpenoids with a C9 side-chain moiety and a hemiacetal moiety formed between C-3 and C-19.

Interface regulation and electrolyte design strategies for zinc anodes in high-performance zinc metal batteries.

Rechargeable zinc metal batteries (ZMBs) represent a promising solution for large-scale energy storage due to their safety, cost-effectiveness, and high theoretical capacity. However, the development of zinc metal anodes is hindered by challenges such as dendrite formation, hydrogen evolution reaction (HER), and low Coulombic efficiency stemming from undesirable interfacial processes in aqueous electrolytes. This review explores various strategies to enhance zinc anode performance, focusing on artificial SEI, morphology adjustments, electrolyte regulation, and flowing electrolyte.

Engineering a promiscuous prenyltransferase for selective biosynthesis of an undescribed bioactive cannabinoid analog.

Cannabinoids are unique meroterpenoids, with cannabigerolic acid (CBGA) serving as a dedicated precursor. This study introduces a fungal aromatic prenyltransferase AscC into the engineered Escherichia coli to catalyze the transfer of C-C terpenoid linear precursors to olivetolic acid. Four CBGA derivatives (compounds 1-4) with diverse C, C, or C prenyl chains are isolated and identified, with compound 4 being an undescribed product featuring a C prenyl chain at the C-5 position.

Longitudinal MRI evaluation of the efficacy of non-enhanced lung cancer brain metastases.

Brain metastases (BM) are the most prevalent intracranial malignancies. Approximately 30-40% of cancer patients develop BM at some stage of their illness, presenting with a high incidence and poor prognosis. Our clinical findings indicate a significant disparity in the efficacy between non-enhanced and enhanced lung cancer BM.

Metagenome-assembled microbial genomes (n = 3,448) of the oral microbiomes of Tibetan and Duroc pigs.

Compared with leaner breeds, local Chinese pig breeds have distinct intestinal microbial, as determined by metagenomic techniques, and the interactions between oral microorganisms and their hosts are also gradually being clarified. However, the high host genome content means that few metagenome-based oral microbiomes have been reported. Here, we combined dilution-based metagenomic sequencing and binning approaches to extract the microbial genomes from the oral microbiomes of Tibetan and Duroc pigs.

A tellurium iodide perovskite structure enabling eleven-electron transfer in zinc ion batteries.

The growing potential of low-dimensional metal-halide perovskites as conversion-type cathode materials is limited by electrochemically inert B-site cations, diminishing the battery capacity and energy density. Here, we design a benzyltriethylammonium tellurium iodide perovskite, (BzTEA)TeI, as the cathode material, enabling X- and B-site elements with highly reversible chalcogen- and halogen-related redox reactions, respectively. The engineered perovskite can confine active elements, alleviate the shuttle effect and promote the transfer of Cl on its surface.

Oral Delivery of 5-Demethylnobiletin by Media-Milled Black Rice Particle-Stabilized Pickering Emulsion Alleviates Colitis in Mice: Synergistic Effects of Carrier and Loaded Bioactive.

Traditional colitis treatment strategies have issues such as side effects and poor lesion targeting. In this study, a milled black rice particle-stabilized Pickering emulsion (BR-5-DMN) has been developed as a delivery vehicle for 5-demethylnobiletin (5-DMN) to treat colitis. The alleviating effects of three 5-DMN delivery systems: BR-5-DMN, Tween 80 emulsion for upper gastrointestinal delivery, and soybean oil with most 5-DMN entering the colon were compared.

Lactic acid contributes to the emergence of depression-like behaviors triggered by blue light exposure during sleep.

The threat posed by light pollution to human health is increasing remarkably. As demand for high-efficiency and bright lighting increases, so does the blue light content from artificial sources. Although animal studies suggested blue light induced depression-like behaviors, human evidence remained limited, and the mechanisms by which blue light affects depression remained elusive.

An integrative approach to identifying as a susceptibility gene for gestational diabetes mellitus.

Objective: The objective of this study was to identify a novel gene and its potential mechanisms associated with susceptibility to gestational diabetes mellitus (GDM) through an integrative approach.

Methods: We analyzed data from genome-wide association studies (GWAS) of GDM in the FinnGen R11 dataset (16,802 GDM cases and 237,816 controls) and Genotype Tissue Expression v8 expression quantitative trait locus data. We used summary-data-based Mendelian randomization to determine associations between transcript levels and phenotypes, transcriptome-wide association studies to provide insights into gene-trait associations, multi-marker analysis of genomic annotation to perform gene-based analysis, genome-wide complex trait analysis-multivariate set-based association test-combo to determine gene prioritization, and polygenic priority scores to prioritize the causal genes to screen candidate genes.

Designing Zwitterionic Bottlebrush Polymers to Enable Long-Cycling Quasi-Solid-State Lithium Metal Batteries.

Ionogel polymer electrolyte (IPE), incorporating ionic liquid (IL) within a polymer matrix, presents a promising avenue for safe quasi-solid-state lithium metal batteries. However, sluggish Li kinetics, resulting from the formation of [Li(anion)] clusters and the occupation of Li transport sites by organic cations, limit their practical applications. In this study, we have developed zwitterionic bottlebrush polymers-based IPE with promoted Li conduction by employing poly(sulfobetaine methacrylate)-grafted poly(vinylidene fluoride-co-chlorotrifluoroethylene) (PVC-g-PSBMA) bottlebrushes as matrices of IL.

A Chemically Defined Culture for Tooth Reconstitution.

It is known for decades that dental epithelium and mesenchyme can reconstitute and regenerate a functional tooth. However, the mechanism of tooth reconstitution remains largely unknown due to the lack of an efficient in vitro model. Here, a chemically defined culture system is established that supports tooth reconstitution, further development with normal anatomy, and prompt response to chemical interference in key developmental signaling pathways, termed as toothoids.

Multi-Omics Reveal the Improvements of Nutrient Digestion, Absorption, and Metabolism and Intestinal Function via GABA Supplementation in Weanling Piglets.

The nonprotein amino acid γ-aminobutyric acid (GABA) can enhance intestinal function in piglets; however, the mechanisms involved are not yet fully understood. To explore the effects of GABA and its underlying mechanisms, weanling piglets were randomly assigned to three groups, receiving either a basal diet or a basal diet supplemented with GABA (80 mg/kg or 120 mg/kg). The results demonstrated that dietary GABA improved growth performance and reduced diarrhea incidence ( < 0.

Multifunctional acoustic and mechanical metamaterials prepared from continuous CFRP composites.

The imperative advance towards achieving "carbon neutrality" necessitates the development of porous structures possessing dual acoustic and mechanical properties in order to mitigate energy consumption. Nevertheless, enhancing various functionalities often leads to an increase in the structural weight, which limits the feasibility of using such structures in weight-sensitive applications. In accordance with the outlined specifications, a novel structural design incorporating carbon fiber reinforced polymer (CFRP) composites alongside mechanical and acoustic metamaterials has been introduced for the first time.