Publications by authors named "Hong Hanh Le"
Article Synopsis
- Helicobacter pylori infects about half of the global population and can cause serious gastric diseases by creating cholesteryl α-glucoside derivatives that disrupt host cell membranes.
- This study focused on how different acyl chains in these derivatives affect membrane properties and bacterial adhesion in human gastric adenocarcinoma cells, using various methods including confocal microscopy and UPLC-MS/MS for lipid analysis.
- Results showed that specific cholesteryl derivatives significantly inhibited bacterial adhesion by altering membrane composition, especially after different treatment times with phosphatidylethanolamine (PE).
The reality and intensity of antibiotic resistance in pathogenic bacteria calls for the rapid development of new antimicrobial drugs. In bacteria, trans-translation is the primary quality control mechanism for rescuing ribosomes arrested during translation. Because trans-translation is absent in eukaryotes but necessary to avoid ribosomal stalling and therefore essential for bacterial survival, it is a promising target either for novel antibiotics or for improving the activities of the protein synthesis inhibitors already in use.
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