Publications by authors named "Hong Gou"
Antiemetic activity of megestrol acetate in patients receiving chemotherapy.
Support Care Cancer
May 2011
Purpose: Several trials had independently noted that patients receiving megestrol acetate had less nausea and vomiting, but this antiemetic activity of megestrol acetate has not been reported separately in the literature. Our objective was to evaluate the antiemetic ability of megestrol acetate in patients receiving chemotherapy.
Patients And Methods: Patients receiving chemotherapy were randomly assigned to receive either megestrol acetate 320 mg PO or placebo before the first day of chemotherapy, followed on days 1-4 by megestrol acetate 320 mg PO combined with granisetron 3 mg IV and metoclopramide 20 mg IM or only granisetron 3 mg IV combined with metoclopramide 20 mg IM in a crossover manner during two consecutive cycles.
A study of the specificity of lymphocytes in nevirapine-induced skin rash.
J Pharmacol Exp Ther
December 2009
Article Synopsis
- Nevirapine, a medication, can cause skin rashes, and researchers developed an animal model to study the rash's underlying metabolic pathway linked to its effects.
- The study involved treating rats with nevirapine and its metabolite 12-OH-nevirapine, analyzing lymphocyte responses through cytokine production and proliferation assays to identify which immune cells were implicated in the rash.
- Findings indicated that lymphocytes responded specifically to nevirapine over its metabolites, suggesting that the immune response's initial triggers may not align with the lymphocytes’ activation patterns, revealing important insights into immune response mechanisms.