Publications by authors named "Hong Duc Du"
Bloodstream infection (BSI) poses a global health problem, with diverse organisms and rising antimicrobial resistance (AMR). Here, we characterized trends in BSI prevalence, AMR, and antibiotic use at a Vietnamese infectious diseases hospital from 2010 to 2020. Among 108,303 cultured blood samples, 8.
View Article and Find Full Text PDFHuman versus equine intramuscular antitoxin, with or without human intrathecal antitoxin, for the treatment of adults with tetanus: a 2 × 2 factorial randomised controlled trial.
Nguyen Van Hao Huynh Thi Loan Lam Minh Yen Evelyne Kestelyn Duc Du Hong Duong Bich Thuy Ha Thi Hai Duong Nguyen Thi Phuong Dung Duncan Wyncoll
Lancet Glob Health
June 2022
Article Synopsis
- This study investigates the effectiveness of intrathecal (spinal) versus intramuscular (muscle) antitoxin treatments in adults with generalized tetanus, addressing concerns about toxin penetration in the central nervous system (CNS).
- Conducted as a factorial trial, 272 patients were randomly assigned to receive either human or equine antitoxin injections and then either an intrathecal antitoxin or a sham procedure to compare outcomes.
- The results showed that 43% of patients receiving intrathecal antitoxin required mechanical ventilation, versus 50% of those in the sham group, indicating no significant difference, while similar rates were observed between human and equine intramuscular treatments.