The mechanisms of resistance, epidemiological characteristics, and molecular evolution of carbapenem-resistant hypervirulent Klebsiella pneumoniae.

Introduction: Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) is a highly pathogenic, drug-resistant, and transmissible "superbug" that causes infections in hospitals and communities. Because of the lack of effective antimicrobial treatment options, morbidity and mortality from CR-hvKP infections have increased dramatically, and outbreaks and the rapid spread of CR-hvKP in hospitals have become a major global public health challenge.

Methods: The mechanisms of molecular evolution in CR-hvKP include the acquisition of a hypervirulent plasmid encoding a virulence gene by carbapenemase-producing K pneumoniae, the horizontal transfer of plasmids carrying carbapenem resistance genes to hvKP, and the acquisition of fusion plasmids carrying both carbapenem resistance genes and hypervirulent genes by classic K pneumoniae.

Deciphering the Basis of Enhanced Na Storage Induced by Halogen Doping in NaVTi(PO).

Elemental doping is a widely adopted strategy to enhance the electrochemical performance of electrode materials, yet limited studies have explored the resulting variations in the bonding environments and the interactions between dopant atoms and their neighboring atoms. In this study, halogen-doped (fluorine, chlorine, and bromine) polyanionic phosphates are synthesized to investigate the effects of halogen doping on the fine crystal structure, chemical micro-environment, and electronic structure of NaVTi(PO) for Na ion storage. Density functional theory analysis reveals that halogen doping strengthens interactions at the Na sites while disrupting their symmetry, thereby promoting Na conductivity.

Effects of exercise on high-density lipoprotein levels in middle-aged and older individuals: A systematic review and meta-analysis.

Background: This study aimed to perform a systematic review and meta-analysis of randomized controlled trials investigating the effect of exercise on high-density lipoprotein (HDL) levels in middle-aged and older individuals.

Methods: A systematic search was conducted in PubMed, Web of Science, and EMBASE, including meta-analyses of randomized controlled trials that investigated the effects of exercise on HDL-C levels in middle-aged and older individuals.

Results: Forty-two trials were analyzed.

Perceived social support and deviant behavior of new street corner youth on campus: a moderated mediation model.

Introduction: The current study aimed to examine the moderated mediation between perceived social support, the deviant behavior of new street corner youth on campus (NSCYC), interpersonal needs (as a mediator), and meaning in life (as a moderator).

Methods: A total of 596 new street corner youth on campus were investigated using the Deviant Behavior Questionnaire, Perceived Social Support Scale, Interpersonal Needs Questionnaire, and Meaning in Life Questionnaire.

Results: The findings showed that: (1) perceived social support significantly and negatively predicted deviant behavior; (2) interpersonal needs mediated the association between perceived social support and deviant behavior; and (3) a moderated mediating role of perceived social support influencing deviant behavior was established, with meaning in life regulating both the direct and the first half paths of the model.

Evolution of Oxygen Content of Graphene Oxide for Humidity Sensing.

Graphene oxide (GO) has shown significant potential in humidity sensing. It is well accepted that the oxygen-containing functional groups in GO significantly influence its humidity sensing performance. However, the relationship between the content of these groups and the humidity sensing capability of GO-based sensors remains unclear.

A cross-sectional survey study on the correlation analysis of nutritional status and intestinal flora in patients with esophageal cancer.

Objective: This study aims to examine the nutritional status of individuals diagnosed with esophageal cancer and compare the nutritional indicators and intestinal flora between malnourished and non-malnourished patients. The findings aim to contribute to the early prevention of malnutrition and the development of interventions targeting the intestinal flora to treat esophageal cancer.

Methods: An 80-patient sample of hospitalized individuals with esophageal cancer was selected from the radiotherapy department of our hospital between July 2021 and July 2022 to evaluate NRS2002 scores and PG-SGA scores.

Process optimization for microfluidic preparation of liposomes using food-grade components.

This study explores the potential for optimizing a sustainable manufacturing process that maintains the essential characteristics of conventional liposomes using food-grade solvents and components. The focus was comparing the physicochemical, morphological, and interfacial properties of liposomes produced with these food-grade ingredients to those made by conventional methods. It was found that there was no significant difference in particle size (195.

N-Containing NaVTi(PO)/C for Aqueous Sodium-Ion Batteries.

Phosphates featuring a 3D framework offer a promising alternative to aqueous sodium-ion batteries, known for their safety, cost-effectiveness, scalability, high power density, and tolerance to mishandling. Nevertheless, they often suffer from poor reversible capacity stemming from limited redox couples. Herein, N-containing NaVTi(PO) is synthesized for aqueous sodium-ion storage through multi-electron redox reactions.

Development and Characterization of Extract-Loaded Liposomes: Potential as Anti-Inflammatory Functional Food Ingredients.

We investigated the potential of extract encapsulated in liposomes as a functional food ingredient with enhanced bioavailability and stability. , known for its anti-inflammatory properties and various health benefits, was encapsulated using a liposome mass production manufacturing method, and the physical properties of liposomes were evaluated. The liposomes exhibited improved anti-inflammatory effects in lipopolysaccharide-activated RAW 264.

Plastid methylerythritol phosphate pathway participates in the hypersensitive response-related cell death in .

Programmed cell death (PCD), a characteristic feature of hypersensitive response (HR) in plants, is an important cellular process often associated with the defense response against pathogens. Here, the involvement of , a gene encoding 4-hydroxy-3-methylbut-2-enyl diphosphate reductase that participates in the final step of the plastid methylerythritol phosphate (MEP) pathway, in plant HR cell death was studied. In plants, silencing of the gene using virus-induced gene silencing (VIGS) caused plant growth retardation and albino leaves with severely malformed chloroplasts.

Self-Assembly of a Graphene Oxide Liquid Crystal for Water Treatment.

Adsorbents, especially those with high removal efficiency, long life, and multi-purpose capabilities, are the most crucial components in an adsorption system. By taking advantage of the liquid-like mobility and crystal-like ordering of liquid crystal materials, a liquid crystal induction method is developed and applied to construct three-dimensional graphene-based adsorbents featuring excellent shape adaptability, a distinctive pore structure, and abundant surface functional groups. When the monoliths are used for water restoration, the large amount of residual oxygen-containing groups is more susceptible to electrophilic attack, thus contributing to cation adsorption (up to 705.

Enhancing the mechanical strength and toughness of epoxy resins with linear POSS nano-modifiers.

Glass transition temperature ( ) always deteriorates while improving the strength of epoxy resins which inherently suffer from brittleness. Herein, novel linear polyhedral oligomeric silsesquioxane (POSS)-epoxy nano-modifiers are synthesized with variable contents of POSS. The thermomechanical properties and chemical structure study of the POSS-epoxy indicates significant differences of the rigid POSS content in the linear nano-modifiers.

One-Pot Synthesis of Cellulose/MXene/PVA Foam for Efficient Methylene Blue Removal.

TiCT MXene has attracted considerable interest as a new emerging two-dimensional material for environmental remediation due to its high adsorption capacity. However, its use is greatly limited by its poor mechanical properties, low processability and recyclability, and the low dispersity of such powder materials. In this work, a porous adsorbent (C-CMP) containing cellulose nanocrystals (CNC), TiCT MXene and polyvinyl alcohol (PVA) was prepared by a simple and environmentally-friendly foaming method.

Monitoring and Analysis of Ground Surface Settlement in Mining Clusters by SBAS-InSAR Technology.

In this paper, we use the small baseline set technology and the early geological hazard identification method based on the selection of Permanent Scatter (PS) and Distributed Scatter (DS) points to carry out the research on surface deformation monitoring caused by underground activities in mining cluster areas. We adopted the Small Baseline Subset InSAR (SBAS-InSAR) technique to process Sentinel-1A SAR images over the research area from March 2017 to May 2021. The deformation estimation technology based on the robustness of PS points and DS points can be used for early identification of high-density surface subsidence in a large area of mines.

Research Progress of Graphene and Its Derivatives towards Exhaled Breath Analysis.

The metabolic process of the human body produces a large number of gaseous biomarkers. The tracking and monitoring of certain diseases can be achieved through the detection of these markers. Due to the superior specific surface area, large functional groups, good optical transparency, conductivity and interlayer spacing, graphene, and its derivatives are widely used in gas sensing.

Physically Crosslinked Chitosan/PVA Hydrogels Containing Honey and Allantoin with Long-Term Biocompatibility for Skin Wound Repair: An In Vitro and In Vivo Study.

Chitosan/PVA hydrogel films crosslinked by the freeze-thaw method and containing honey and allantoin were prepared for application as wound dressing materials. The effects of the freeze-thaw process and the addition of honey and allantoin on the swelling, the gel content and the mechanical properties of the samples were evaluated. The physicochemical properties of the samples, with and without the freeze-thaw process, were compared using FTIR, DSC and XRD.

Effectiveness of an ocular adhesive polyhedral oligomeric silsesquioxane hybrid thermo-responsive FK506 hydrogel in a murine model of dry eye.

Dry eye is a common ocular disease that results in discomfort and impaired vision, impacting an individual's quality of life. A great number of drugs administered in eye drops to treat dry eye are poorly soluble in water and are rapidly eliminated from the ocular surface, which limits their therapeutic effects. Therefore, it is imperative to design a novel drug delivery system that not only improves the water solubility of the drug but also prolongs its retention time on the ocular surface.

Untreated Prior Pulmonary Tuberculosis Adversely Affects Pregnancy Outcomes in Infertile Women Undergoing Fertilization and Embryo Transfer: A Large Retrospective Cohort Study.

Objective: Prior pulmonary tuberculosis (PTB) on chest X-ray (CXR) was commonly found in infertile patients receiving examinations before fertilization and embryo transfer (IVF-ET). It was unclear whether untreated PTB would affect pregnancy outcomes after IVF-ET.

Method: We conducted a retrospective cohort study of 14,254 infertile patients who had received IVF-ET at Peking University Third Hospital in 2017.

Self-Luminescent Lanthanide Metal-Organic Frameworks as Signal Probes in Electrochemiluminescence Immunoassay.

The successful use of electrochemiluminescence (ECL) in immunoassay for clinical diagnosis requires development of novel ECL signal probes. Herein, we report lanthanide (Ln) metal-organic frameworks (LMOFs) as ECL signal emitters in the ECL immunoassay. The LMOFs were prepared from precursors containing Eu (III) ions and 5-boronoisophthalic acid (5-bop), which could be utilized to adjust optical properties.

Recent progress in using hybrid silicon polymer composites for wastewater treatment.

Heavy metal ions, oil and organic pollutants in water does not only cause serious water pollution, but also pose serious threats to ecosystems and human health. To this end, water pollution has gradually gained human attention, and various wastewater treatment methods are emerging. Organosilicon polymer composites are a class of materials that contain organic-inorganic hybrid structures with the characteristics of hydrophobicity, thermal stability and easy modification, which provides a brand new solution for wastewater treatment.

The association between prenatal endocrine-disrupting chemical exposure and altered resting-state brain fMRI in teenagers.

Many studies have reported that prenatal exposure to endocrine-disrupting chemicals (EDCs) can cause adverse behavioral effects or cognitive dysfunction in children. This study aimed to investigate a relationship of the concentration of prenatal EDCs and brain function in teenagers. We recruited 59 mother-child pairs during the third trimester of pregnancy, and collected and examined the concentration of EDCs, such as heavy metals, phthalates and perfluoroalkyl substances (PFASs), in maternal urine and serum.

Lemon Balm and Its Constituent, Rosmarinic Acid, Alleviate Liver Damage in an Animal Model of Nonalcoholic Steatohepatitis.

Nonalcoholic fatty liver disease (NAFLD) ranges in severity from hepatic steatosis to cirrhosis. Lemon balm and its major constituent, rosmarinic acid (RA), effectively improve the liver injury and obesity; however, their therapeutic effects on nonalcoholic steatohepatitis (NASH) are unknown. In this study, we investigated the effects of RA and a lemon balm extract (LBE) on NAFLD and liver fibrosis and elucidated their mechanisms.

Glycerol Waste Valorization to Mesoxalic Acid Over a Bimetallic Pt-Pd/CNT Catalyst in Alkaline Medium.

Glycerol electro-oxidation offers a green route to produce the high value added chemicals. Here in, we report the glycerol electro-oxidation over a series of multi walled carbon nano tubes supported monometallic (Pt/CNT and Pd/CNT) and bimetallic (Pt-Pd/CNT) catalysts in alkaline medium. The cyclic voltammetry, linear sweep voltammetry and chronoamperometry measurements were used to evaluate the activity and stability of the catalysts.

Star-Shaped Crosslinker for Multifunctional Shape Memory Polyurethane.

Star-shaped cyclophosphazene (ACP) was employed as covalent crosslinker to form a rigid segment in polyurethanes network, to enhance the mechanical performance and to add extra flame retardant property. The effects of different ACP contents on the shape memory ability and fire resistance performance of polyurethane (PU) were studied. Tensile tests suggested high flexibility of the PUs with the maximum elongation-at-break of 161.