Publications by authors named "Hon-Ting Lok"
Background: Intraductal papillary mucinous tumour (IPMN) of pancreas is increasingly recognized to have malignant potential. Fukuoka guidelines are commonly used to select patients with IPMN for resection due to high chance of malignancy, which includes high-grade dysplasia (HGD) or invasive carcinoma (IC).
Methods: A retrospective study on consecutive patients who have undergone pancreatectomy with IPMN as the final pathology was performed.
Article Synopsis
- - The study investigates the effectiveness of laparoscopic liver resection (LLR) vs. open liver resection for patients with hepatocellular carcinoma (HCC) classified as high difficulty, focusing on both short-term and long-term clinical outcomes.
- - Results show that the laparoscopic approach leads to fewer severe complications (3% vs. 10.8%) and shorter hospital stays (6 days vs. 8 days), while the long-term survival rates remain similar for both methods.
- - Overall, LLR demonstrates better short-term outcomes without compromising long-term survival, making it a viable option for selected HCC patients.
Background: Hepatectomy is an established treatment for colorectal liver metastasis (CLM) or neuroendocrine liver metastasis. However, its role in non-colorectal non-neuroendocrine liver metastasis (NCNNLM) is controversial. This study aims to compare long-term survival outcomes after hepatectomy between NCNNLM and CLM in a population-based cohort.
View Article and Find Full Text PDFA case series of emergency pancreaticoduodenectomies: What were their indications and outcomes?
Ann Hepatobiliary Pancreat Surg
November 2023
Emergency pancreaticoduodenectomy (EPD) is a rarely performed operation. It is important to know the indications and outcomes of EPD to have a better understanding of its application in clinical practice. A review of eight consecutive cases of EPD was done.
View Article and Find Full Text PDFPurpose: To compare the peri-operative and long-term survival outcomes of minimally invasive liver resection (MILR) (robotic or laparoscopic) with open liver resection (OLR) in patients with hepatocellular carcinoma (HCC).
Methods: Data of patients who underwent liver resection for HCC were reviewed from a prospectively collected database. Outcomes of MILR were compared with those of OLR.
Article Synopsis
- The study explored the impact of involved resection margins (R0 vs. R1) during pancreaticoduodenectomy for periampullary and pancreatic head carcinoma on long-term outcomes.
- Results showed that R1 resection occurred in 12% of periampullary and 20% of pancreatic head cancers, with R1 associated with more lymph node metastasis but not affecting overall survival (OS) or disease-free survival (DFS).
- The findings concluded that involved resection margins did not lead to higher recurrence rates and were not significant predictors of poor OS or DFS.
Background: Hepatic resection (HR) is effective for colorectal or neuroendocrine liver metastases. However, the role of HR for non-colorectal non-neuroendocrine liver metastases (NCNNLM) is unknown. This study aims to perform a systematic review and meta-analysis on long-term clinical outcomes after HR for NCNNLM.
View Article and Find Full Text PDFArticle Synopsis
- A study was conducted to assess the relationship between pancreatic duct size and the risk of postoperative pancreatic fistula (POPF) in patients undergoing duct-to-mucosa pancreaticojejunostomy (DTMPJ) after pancreaticoduodenectomy.
- Out of 288 patients studied from 2003 to 2019, 56.3% experienced POPF, with the highest incidence occurring in those with duct diameters ≤ 1 mm, showing a significant risk increase compared to larger ducts.
- The findings suggest that DTMPJ is safe for patients with pancreatic ducts larger than 1 mm, indicating that smaller duct size is a predictor for higher POPF rates, especially in patients with a soft pancreas.
Background: Robotic distal pancreatectomy has been accepted to be safe and effective for pancreatic tail lesion. Whether spleen preservation by preserving the splenic vessels with robot assistance is feasible and beneficial remains controversial. Here we would like to compare the operative outcomes of robotic distal pancreatectomy and splenectomy (DPS) with robotic spleen preserving distal pancreatectomy by means of splenic vessel preservation (SVP).
View Article and Find Full Text PDFIntroduction: Although hepatectomy is a curative treatment modality for hepatocellular carcinoma (HCC), the associated 10-year long-term actual survival are rarely reported. This study aims to develop and validate a predictive nomogram for 10-year actual survivors with HCC.
Materials And Methods: From 2004 to 2009, 753 patients with curative hepatectomy for HCC (development set, n = 325; validation set, n = 428) were included.
Background And Aim: Obesity is becoming increasingly prevalent in Asia. Bariatric surgery in the region is growing in popularity to reflect increasing demand. Hiatal hernia (HH) is common among the obese population.
View Article and Find Full Text PDFAnalysis for actual mid-term (≥5 years) and long-term (≥10 years) survivors with hepatocellular carcinoma (HCC) following curative hepatectomy are rarely reported in the literature.This retrospective study aims to study the mid- and long-term survival outcome and associated prognostic factors following curative hepatectomy for HCC in a tertiary referral center.The clinical data of 325 patients who underwent curative hepatectomy for HCC were reviewed.
View Article and Find Full Text PDFBackground: Liver resection is an established treatment of choice for colorectal liver metastasis (CLM). However, the role of hepatectomy for non-colorectal liver metastasis (NCLM) is less clear.
Patients And Method: From 2004 to 2017, 264 patients received curative hepatectomy for NCLM (n = 28) and CLM (n = 236).
Background: Minimally invasive approach has been increasingly applied in liver resection. However, laparoscopic major hepatectomy is technically demanding and is practiced only in expert centers around the world. Conversely, use of robot may help to overcome the difficulty and facilitate major hepatectomy.
View Article and Find Full Text PDFBackground: Hepatectomy remains an important curative treatment for hepatocellular carcinoma (HCC). Intermittent Pringle maneuver (IPM) is commonly applied during hepatectomy for control of bleeding. Whether the ischemia/reperfusion injury brought by IPM adversely affects the operative outcomes is controversial.
View Article and Find Full Text PDFBackground: Hepatectomy is a widely accepted curative treatment for hepatocellular carcinoma (HCC). However, the disease frequently recurs after a curative hepatectomy. The objective of this study is to provide a better understanding of the pattern of disease recurrence and the risk factors involved so as to improve the postoperative surveillance.
View Article and Find Full Text PDFA 51-year-old man who was a hepatitis B carrier presented with ruptured hepatocellular carcinoma (HCC). Hepatic arterial embolization was performed for control of bleeding which was followed by staged open left lateral sectionectomy for tumor removal. Pathology confirmed a 3.
View Article and Find Full Text PDFBackground: Studies comparing microwave ablation (MWA) and liver resection are lacking. This study evaluates the survival of patients with hepatocellular carcinoma (HCC) treated with liver resection or MWA and the role of Albumin-Bilirubin (ALBI) score in patient selection for treatments.
Methods: This is a retrospective analysis of patients who received curative liver resection or MWA for HCC.