Publications by authors named "Hon-Kit Andus Wong"

Background: Given multiple studies of brain microRNA (miRNA) in relation to Alzheimer's disease (AD) with few consistent results and the heterogeneity of this disease, the objective of this study was to explore their mechanism by evaluating their relation to different elements of Alzheimer's disease pathology, confounding factors and mRNA expression data from the same subjects in the same brain region.

Methods: We report analyses of expression profiling of miRNA (n = 700 subjects) and lincRNA (n = 540 subjects) from the dorsolateral prefrontal cortex of individuals participating in two longitudinal cohort studies of aging.

Results: We confirm the association of two well-established miRNA (miR-132, miR-129) with pathologic AD in our dataset and then further characterize this association in terms of its component neuritic β-amyloid plaques and neurofibrillary tangle pathologies.

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Article Synopsis
  • Researchers analyzed The Cancer Genome Atlas data to find microRNAs linked to glioblastoma (GBM) survival, pinpointing miR-148a and miR-31 as key players in tumor growth.
  • * In mouse models, blocking these microRNAs led to decreased tumor size and increased survival rates, indicating their role in cancer progression.
  • * The study reveals that miR-148a and miR-31 contribute to glioma growth by influencing tumor stem cells and enabling blood vessel formation, even in normal oxygen conditions, highlighting a novel therapeutic approach using antagomirs.
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Alzheimer's disease (AD) is a multifactorial and fatal neurodegenerative disorder for which the mechanisms leading to profound neuronal loss are incompletely recognized. MicroRNAs (miRNAs) are recently discovered small regulatory RNA molecules that repress gene expression and are increasingly acknowledged as prime regulators involved in human brain pathologies. Here we identified two homologous miRNAs, miR-132 and miR-212, downregulated in temporal cortical areas and CA1 hippocampal neurons of human AD brains.

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