Publications by authors named "Homero Soares Fogaca"
Background/objectives: Chronic pancreatitis (CP) is a progressive inflammatory disorder associated with marked morbidity and mortality and frequently requires hospitalization. This study aimed to investigate the time trends and geographical distribution of hospital admissions, the lethality rate of CP across Brazil, and the potential relationship with social indicators and associated risk factors.
Methods: Data were retrospectively obtained from the Brazilian Public Health System Registry between January 2009 and December 2019.
Article Synopsis
- The study aimed to explore the connection between genetic variants in NOD2/CARD15 and TLR4 with Crohn's Disease (CD) and ulcerative colitis (UC) in a population from Rio de Janeiro, where rates of inflammatory bowel disease (IBD) are increasing.
- Researchers analyzed DNA from 67 CD patients, 61 UC patients, and 86 healthy controls, using various genotyping methods to identify specific single-nucleotide polymorphisms (SNPs).
- The findings indicated that the genetic variants did not increase the risk of IBD, but certain SNPs were linked to specific disease characteristics in CD, such as colonic involvement and the necessity for certain treatments, particularly in males.
Aim: To investigate the geographic distributions and time trends of gastric cancer (GC) incidence and mortality in Brazil.
Methods: An ecological study of the DATASUS registry was conducted by identifying hospitalizations for GC between January 2005 and December 2010. The data included information on the gender, age, and town of residence at the time of hospital admission and death.
Objectives: Intestinal neovascularization and abnormal abdominal arterial flow rates have been reported in Crohn's disease. The aim of this study was to evaluate Doppler sonography as a method for assessing Crohn's disease activity based on changes in splanchnic hemodynamics.
Methods: Forty-eight patients with Crohn's disease, 22 healthy volunteers and 12 patients with irritable bowel syndrome were evaluated by Doppler ultrasound for flow parameters of the aorta and superior mesenteric artery.
Mutations of the p53 tumor suppressor gene have been associated with abnormalities in cell cycle regulation, DNA repair and synthesis, apoptosis, and it has been implicated in the prognosis of advanced gastric cancer. The aim of this study was to evaluate the occurrence of p53 gene mutation and its possible prognostic implications in early gastric cancer. In a retrospective study, we studied 80 patients with early gastric cancer treated surgically between 1982 and 2001.
View Article and Find Full Text PDFAim: To evaluate the prevalence of hepatitis B virus (HBV) infection in inflammatory bowel disease (IBD) patients that followed up in our hospital and try to identify the possible risk factors involved in this infection transmission.
Methods: This was a cross-sectional study for which 176 patients were selected according to their arrival for the medical interview. All these patients had already IBD diagnosis.
[Descriptive analysis of the social, clinical, laboratorial and anthropometric profiles of inflammatory bowel disease inwards patients from the "Clementino Fraga Filho" University Hospital, Rio de Janeiro, RJ, Brazil].
Arq Gastroenterol
December 2008
Background: The epidemiologic survey in Brazil is limited probably due to a diagnosis deficiency and a small number of population-based studies performed. The majority of the prevalence studies available have evaluated inflammatory bowel diseases outpatients, but the knowledge of the profile of inflammatory bowel diseases inpatients is important in order to detect predictive markers of disease severity that will allow earlier medical intervention decreasing the rate of hospitalization and reducing the Health System costs.
Aim: To determine social, clinical, laboratorial and anthropometric profiles of hospitalized adults inflammatory bowel diseases patients of a tertiary university hospital.