Publications by authors named "Homayun Dolatkhah"
Article Synopsis
- - Gastric cancer is a major health concern, being the third leading cause of cancer-related deaths globally, and this study examines the impact of polyunsaturated fatty acids (PUFAs) on improving chemotherapy effectiveness.
- - In a randomized, double-blind trial involving 34 gastric cancer patients, one group received cisplatin with a placebo while the other group received cisplatin with PUFAs over three courses, with their MMP (matrix metalloproteinases) levels monitored.
- - Results showed that those who received PUFAs had significantly lower expressions of MMP-1 and MMP-9, suggesting that PUFAs may help inhibit the invasion and spread of gastric cancer cells.
Drug-resistant strains of Helicobacter pylori and poor treatment response are the main reasons for the failure in eradicating it in patients. Polyunsaturated fatty acids (PUFA) have an inhibitory effect on bacterial growth. The aim of this study was to investigate the effect of PUFA in combination with standard triple therapy on apoptosis in H.
View Article and Find Full Text PDFBackground: Studies show that polyunsaturated fatty acids (PUFAs) may have an inhibitory role in carcinogenesis. It was previously shown that PLA2 group 2A (PLA2G2A) messenger RNA (mRNA) expression is associated with less frequent metastasis and longer survival in gastric adenocarcinoma. This study intends to investigate the effect of PUFAs on the expression of PLA2G2A in patients with gastric cancer.
View Article and Find Full Text PDFObjective: Gastric cancer is the fourth most common cancer and the second cause of death in the world. According to the studies, the gastric cancer is relatively sensitive to chemotherapy. The aim of this study was to investigate the association of oral administer PUFAs with Caspase enzymes in patients with gastric cancer under chemotherapy.
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