Association of the Variations and the Risk of Non-Syndromic Cleft Lip and Palate in a Population of Iranian Infants.

Background: Nonsyndromic cleft lip and/or palate (NSCL/P) is the most common orofacial birth defect, often attributed to ethnic and environmental differences. Up to now, linkage analyses and genome-wide association studies have identified several genomic susceptibility regions for NSCL/P. The genes including are strong candidates for NSCL/P, since they are involved in regulating mid-face development and upper lip fusion.